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A renal abscess in the isthmus of horseshoe kidney

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Krzysztof Balawender K., Stanisław Orkisz S., Przemysław Biela P., Anna Sęk-Mastej A.
European Journal of Clinical and Experimental Medicine
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2017
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issue 3
279-281
EN
Horseshoe kidney (HSK) is the renal fusion anomaly caused by disturbances in embryonic development when the kidneys are fused together in the lower or upper pole forming an isthmus. The most common disorders in urinary tract related to horseshoe kidney are ureteral pelvic junction obstruction, urinary tract infection and urolithiasis. In our study, we present a rare case of an abscess in the isthmus of horseshoe kidney after extracorporeal shockwave lithotripsy on the right kidney was performed. The patient has had recurrent urolithiasis and underwent 4 treatments on the left kidney in the past without complications.
2
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The effect of alcohol on neuroglia in the developing brain and in adults

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Izabela Krawczyk-Marć I., Sabina Galiniak S., Anna Sęk-Mastej A., Mateusz Marć M., Stanisław Orkisz S., Agata Wawrzyniak A.
European Journal of Clinical and Experimental Medicine
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2018
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issue 4
335-340
EN
Introduction. During puberty, the young body undergoes transformation not only within the reproductive and hormonal systems, but also significant changes in the central nervous system (CNS). Matured neural connections improve the integration of distant brain regions, the plasticity of neurons increases, and thus specialization of the brain occurs in the performance of specific tasks. During these transformations, both neurons and the accompanying neuroglia are sensitive to all toxic factors, among which ethanol occupies a special place. It causes an increase in the activity of glial cells, which by directing pro-inflammatory cytokines directly contribute to the death of apoptotic neurons. A long-lasting and irreversible impairment of brain function, especially in the hippocampus occurs as a result of alcohol abuse during the period of development. Aim. This paper presents an overview of current knowledge about the effects of alcohol on neuroglia in the developing brain and in adults. Materials and methods. The literature review of the following databases has been conducted: EBSCO, PubMed, Science Direct, Springer Link. Conclusions. The results of alcohol research have shown that it affects the neurotransmission and fluidity of cell membranes, changing the activity of neurons. By binding to GABA receptor (GABA) and N-methyl-D-aspartate receptors (NMDA receptor for glutamate), ethanol suppresses brain function. In addition to increased sensitivity and susceptibility to the addictive effects of ethanol, the neurogeneration activity is intensified followed by the induction and release of pro-inflammatory cytokines, which in the first stage disrupt the cortical function hindering logical thinking and disrupting the limbic system, directly affecting the memory and learning processes. Next, the cerebellum is attacked, which results in the impairment of balance and motor coordination, and consequently acts on the brain stem, directly affecting the respiratory and circulatory control centers.
3
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Clinical aspects of protein glycation

76%
Sabina Galiniak S., Izabela Krawczyk-Marć I., Anna Sęk-Mastej A., Natalia Leksa N., Marek Biesiadecki M., Stanisław Orkisz S.
European Journal of Clinical and Experimental Medicine
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2017
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issue 3
263-267
EN
Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple sclerosis. Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge about the role of glycation in multiple sclerosis. Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature. Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker.
4
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Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development

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Anna Sęk-Mastej A., Sabina Galiniak S., Izabela Krawczyk-Marć I., Krzysztof Balawender K., Artur Szymczak A., Maciej Kaniewski M., Natalia Leksa N., Marek Biesiadecki M., Stanisław Orkisz S.
European Journal of Clinical and Experimental Medicine
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2018
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issue 2
85-91
EN
Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
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