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Salivary hexosaminidase B in children with type 1 diabetes

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Zalewska-Szajda B., Chojnowska S., Waszkiewicz N., Gościk E., Łebkowska U., Kępka A., Bossowski A., Kuźmiuk A., Mierzyńska K., Szajda S., Ładny J.

Progress in Health Sciences

2012

vol. 2

issue 2

null-140

Introduction: Children type 1 diabetes is accompanied by inflammation and microangiopathy pro-ceeded with increased degradation of tissues. Nacetyl-β-hexosaminidase (HEX) is the most active of exoglycosidases degrading oligo-saccharide chains of glycoconjugates (glycoproteins, glycolipids and proteoglycans). Purpose: To evaluate the hexosaminidase B (HEX B) activity in the saliva of children with type 1 diabetes. Materials and methods: The study was performed in 35 children with type 1 diabetes and 20 healthy children. Salivary HEX B activity was determined by the colorimetric, and protein by bicinchoninic acid methods. The HEX B activity concentration was expressed in pKat/mL and specific activity in pKat/µg of protein. Results: A significant increase in the concentration and the specific activity of HEX B in the saliva of children with type 1 diabetes, as compared to healthy children, was found. Conclusion: Children suffering from type 1 diabetes have increased catabolism of salivary gly-coconjugates by HEX B, which potentially may be useful in the diagnosis of type 1 diabetes in children.

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1 Progress in Health Sciences

1 Bossowski A.

1 Chojnowska S.

1 Gościk E.

1 Kuźmiuk A.

1 Kępka A.

1 Mierzyńska K.

1 Szajda S.

1 Waszkiewicz N.

1 Zalewska-Szajda B.

1 Ładny J.

1 Łebkowska U.

1 2012

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Salivary hexosaminidase B in children with type 1 diabetes