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Granular cell tumor of the neurohypophysis – a case report

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Rafał Dziedzic R., Natalia Leksa N., David Aebisher D., Dorota Bartusik-Aebisher D.
European Journal of Clinical and Experimental Medicine
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2019
|
issue 4
378-380
EN
Introduction. The granulomatous tumor (GCT) is formed from the posterior pituitary (neurohypophysis) or its pedicle. The location of such a tumor in the region of the Turkish or supra saddle is a very rare matter. Aim. To present a case report. Description of the case. This article describes the case of a 39-year-old man admitted to the Department of Neurosurgery with a MR-diagnosed head tumor in the suprasellar area growing out of the pituitary funnel. The tumor appeared to be an epileptic fit. Conclusion. Herein we described a clinical case of granulomatous tumor. GCTs in the pituitary nerves are benign tumors, which makes treatment dependent on the individual case. After the operation, the H-P study showed a granulomatous tumor (GCT) of the posterior pituitary gland.
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The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine

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Natalia Leksa N., Anna Pękala A., Piotr Pardak P., Rafał Dziedzic R., Dorota Bartusik-Aebisher D., Rafał Filip R., Sabina Galiniak S., David Aeisher D.
European Journal of Clinical and Experimental Medicine
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2020
|
issue 1
20-23
EN
Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.
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