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Ovarian cancer and inflammation. Part 2. Anti-inflammatory cytokines

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Terlikowska, K.M, Dobrzycka B., Terlikowski S.
Progress in Health Sciences
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2018
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vol. 8(2)
206-209
EN
Inflammation plays a key role in epithelial ovarian cancer tumorigenesis and progression. The growth and progression of epithelial ovarian cancer may be due to local cytokine-induced immunosu-ppression, which may lead to an immunity impairment. Thus, cytokine antagonism may be an essential factor in the treatment of ovarian cancer. Based on the increased knowledge on the role of the immune system in ovarian cancer, major improvements are to be expected of immunotherapy based treatment of this disease. This article aims to summarize the current literature views on the evidence for a role for chronic inflammation with a specific focus on anti-inflammatory cytokines.
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Ovarian cancer and inflammation. Part 1. Pro-inflammatory cytokines.

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Terlikowska K., Strzyż-Skalij M., Kryński K., Osmólska M., Łada Z., Malinowska-Gleń M., Kryńska E., Terlikowski R.
Progress in Health Sciences
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2018
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vol. 8(1)
194-201
EN
Ovarian cancer is the most threatening cause of death among gynecologic malignancies and represents the fifth leading cause of death from all cancers for women. Research reveals that ovarian cancer patients exhibit significant immune responses against the tumor. In this review of the current literature chiefly the interaction of ovarian cancer tumor cells and the immune system is discussed. There is increasingly growing evidence that pro-inflammatory cytokines are involved in intricate complex of mechanisms responsible for tumorigenesis, and delicate balance between pro- and anti-inflammatory cytokines is critical for the antitumor host immune response.
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