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The study presents the state-of-art of knowledge of risk factors of drug use as a form of risk behaviour in adolescents in individual, interpersonal, and environmental domain (family, school, society). The attention is paid to general deviation syndrome and to the construct of general tendency to drug use. The authors emphasise the need of following the interactions and potentials of changing the risk factors, moderators, and mediators of drug use in adolescents. Recommendations for prevention of drug dependences are formulated.
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