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The usage of scale in grading of patients with brain tumors in neurological nurse practice – preliminary report

100%
Królikowska A., Jabłońska R., Ślusarz R.
Family Medicine & Primary Care Review
|
2013
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issue 4
544-548
2
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An overview of the preclinical and clinical studies of the effects of tumor treating fields on malignant glioma cells

88%
Dorota Bądziul D., Agnieszka Banaś-Ząbczyk A., Jacek Tabarkiewicz J.
European Journal of Clinical and Experimental Medicine
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2017
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issue 2
141-144
EN
Anaplastic astrocytoma (AA, WHO grade III) and glioblastoma multiforme (GBM, WHO grade IV) are malignant tumors of the brain. The average survival time of patients with GMB is approximately one year and two years in the case of anaplastic astrocytoma with standard therapy based on surgical tumor resection followed by chemotherapy or radiotherapy. High invasiveness of gliomas, the ability of rapid division and so-called diffusive infiltration of tumor cells into normal brain tissue, which prevents complete surgical removal, are hallmarks of theses tumors. Therefore, new specific therapies for eliminating cancer cells are needed to treat this tumors. Recently, it has been demonstrated that alternating electric field, also known as tumor treating fields (TTFields) has a unique mechanism of destroying glioma cells. TTFields applies electromagnetic energy frequency-dependent and intensitydependent and disrupts cancer cell replication as they undergo mitosis. Futhermore, TTFields turn out to act comparably to conventional chemotherapeutics, lacking numerous side adverse associated with chemotherapy. The authors provide an up-todate review of the mechanism of action as well as preclinical and clinical data on TTFields.
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Kilka uwag w kwestii nowych hipotez na temat stanu zdrowia Gajusza Juliusza Cezara

45%
Bartnik A.
Przegląd Nauk Historycznych
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2021
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vol. 20
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issue 1
27-45
EN
Countless works have been devoted to Gaius Julius Caesar. All the aspects of the leader’s life have captured the interest of researchers. Information on the health condition of the famous politician was provided, among others, by Suetonius, Pliny the Elder, Appian of Alexandria, Plutarch of Cheronea and Cassius Dio. The preserved messages are highly fragmented, and their authors were not medics, which significantly affects the quality of the information. Nevertheless, the symptoms described by the ancients clearly indicate the health problems that Caesar had to deal with. The fragmentary nature of the descriptions and the lack of bone material make it impossible to clearly define which disease he suffered from. For this reason, a number of hypotheses have arisen regarding the causes described in the sources of attacks. The most popular were epilepsy, Meniere’s disease, brain tumour, neurosyphilis, parasite infection and Hartnup disease. In recent years, celiac disease has also been mentioned. Due to the inability to test the “patient”, all of them remain within the sphere of hypotheses, but today, taking into account the symptoms observed in Caesar, the most likely disease seems to be a brain tumour or a series of micro-haemorrhages. Hartnup disease seems to be an extremely interesting and probable option, but due to its hereditary nature, the problem should be investigated and discussed more broadly, taking into account the entire Julius family.
PL
Gajuszowi Juliuszowi Cezarowi poświęcono niezliczoną liczbę prac. Wszystkie aspekty życia wodza budziły zainteresowanie badaczy. Informacje na temat stanu zdrowia słynnego polityka przekazali m.in. Swetoniusz, Pliniusz Starszy, Appian z Aleksandrii, Plutarch z Cheronei czy Kasjusz Dion. Zachowane relacje są mocno fragmentaryczne, a ich autorzy nie byli medykami, co znacząco wpływa na jakość przekazu. Niemniej opisane przez antycznych pisarzy objawy jasno wskazują na problemy zdrowotne, z którymi musiał się borykać Cezar. Fragmentaryczność opisów oraz brak materiału kostnego uniemożliwiają jednoznaczne określenie, na jaką chorobę cierpiał słynny polityk. Z tego powodu powstał szereg hipotez dotyczących przyczyn opisywanych w źródłach ataków. Wśród najpopularniejszych wymieniano epilepsję, chorobę Meniera, guz mózgu, neurosyfilis, zakażenie pasożytami czy chorobę Hartnupów. W ostatnich latach wspominano także o celiakii. Ze względu na brak możliwości przebadania „pacjenta” wszystkie pozostają w sferze hipotez niemniej obecnie. Biorąc pod uwagę objawy zaobserwowane u Cezara, najbardziej prawdopodobną chorobą wydaje się guz mózgu lub seria mikroudarów. Niezwykle ciekawą i prawdopodobną opcją wydaje się choroba Hartnupów, ale ze względu na jej dziedziczny charakter problem należy przebadać i omówić szerzej, uwzględniając cały ród Juliuszów.
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