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Impact of chemotherapy on antioxidant micronutrient levels in patients with mature lymphoid malignancies

100%
Akunwata C. U., Olaniyi J. A.
European Journal of Clinical and Experimental Medicine
|
2021
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issue 3
209-214
EN
Introduction. Cancer treatments are now intense and are associated with nutritional deficiencies. The nutritional status of a patient may influence the tolerability of chemotherapy. Aim. We investigated the effects of chemotherapy on serum levels of trace elements (copper, iron, manganese, selenium, and zinc) and vitamins (A, C, and E) in patients with mature lymphoid malignancies (MLMs) at diagnosis and after 3 months. Material and methods. A case-control study of adults diagnosed with and treated for various MLMs. Thirty-nine cases and 39 age and sex-matched controls were recruited into this study. Venous blood samples were collected from the controls, cases at baseline and after 3 months of chemotherapy. Trace elements were determined by AAS while vitamins were determined by HPLC. Results. The levels of trace elements and antioxidant vitamins A and E were significantly higher (p<0.001) in cases than in controls while vitamin C was lower in cases compared to controls (p=0.005). After 3 months of treatment, 28 patients were available for analysis. There was a significant decline (p<0.001) in all the levels of trace elements and vitamins after chemotherapy. Conclusion. Chemotherapy is associated with a significant reduction in antioxidants levels in patients with MLMs.
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A nursing perspective of nutrition in cancer patients undergoing chemotherapy

75%
Lavdaniti M.
Progress in Health Sciences
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2014
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vol. 4
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issue 2
131-134
EN
Purpose: To present of an appropriate diet consists in cancer patients undergoing chemotherapy. Materials and methods: A search was made in the Pubmed and Scopus databases for reports on nutrition and chemotherapy in cancer patients. There were used the following key words: nutrition, cancer, chemotherapy and the combination of them. Results: Nutritional problems of patients are caused by the same disease, the antitumor therapy and the patient's response to the diagnosis and treatment. Symptoms such as anorexia, changes in taste, nausea - vomiting, diarrhea, stomatitis and constipation are common side effects of chemotherapy and can lead to inadequate food intake and consequently, malnutrition. There are many appropriate nursing interventions that alleviate the above symptoms. Conclusions: Nurse plays an important role in the care of patients who have been feeding problems receiving chemotherapy. Nutritional interventions are individualized and should be started immediately and incorporated into the care plan in order to be successful. In order this to be achieved; all patients should be assessed for nutritional problems and weight loss before starting treatment and after starting regularly.
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