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Tumor budding as a new histological parameter in the metastasis of colorectal cancer

100%
Ustymowicz W.
Progress in Health Sciences
|
2018
|
vol. 8(2)
118-123
EN
Introduction:The presence of tumor budding, i.e.,single cancer cells or a nest of poorly differentiated cells at the front of tumor invasion appears to be a new histopathological indicator of increased aggressiveness of colorectal carcinoma. Purpose: The aim of this work was a retrospective evaluation of the invasion front (tumorbudding, vascular invasion,and lymphocytic infiltration) in postoperative biopsies of patients with colorectal carcinoma and analysis of the 5-year survival. Materialsand methods:The study was based on the material received after surgical treatment of 164 patients with colon cancer. Tissue was obtained directly following tumor resection, fixed in 10% formaldehyde and embedded in paraffin blocks using a routine method by melting with paraffin at a temperature of 56º C. These samples were then routinely stained with haematoxylin and eosin and underwent a histopathological evaluation, with particular attention being paid to the invasion front of the tumor. The immunohistochemical expression of cytokeratin 20 was also evaluated using anti-human CK20 monoclonal antibody (clone Ks.20.8, Dako, Poland). Results: Tumor budding was found in 124 out of 164 patients. Statistical analysis showed a correlation between the presence of tumor budding TB and depth of invasion (pT), lymph node metastasis, distant metastasis, lymphocytic infiltration,and vascular invasion. The cumulative five-year survival correlated with the lack of tumor budding and vascular invasion, as well as a decrease in lymphocyticinfiltration.
2
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The role of new biomarkers for the diagnosis and treatment of colon cancer

80%
Czarnecka-Czapczyńska M., Bartusik-Aebisher D., Krupka-Olek M., Aebisher D., Cieślar G., Latos W., Kawczyk-Krupka A.
European Journal of Clinical and Experimental Medicine
|
2021
|
issue 4
326-329
EN
Introduction. Colorectal cancer may be benign or malignant. According to the World Health Organization and CDC, it is the second most common cancer worldwide, after lung cancer. The mortality of colorectal cancer has been dropping for more than 20 years due to the improvements in screening techniques and treatments. Aim. The aim of this article is to discuss the role of new biomarkers for the diagnosis and treatment of colon cancer. Material and methods. This article is a review done in regards to discuss the role of new biomarkers for the diagnosis and treatment of colon cancer. Analysis of the literature. A review is discussed the role of new biomarkers for the diagnosis and treatment of colon cancer using current literature. Conclusion. The screening tests based on diagnostic new biomarkers may cause faster detection of cancer and risk factors, and provide prognostic information in order to adjust individual therapy.
3
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Readability and lexical sophistication of colon cancer websites – a corpus-assisted assessment of online educational materials for patients

36%
Bączkowska A.
Forum Filologiczne Ateneum
|
2019
|
vol. 7
|
issue 1
9-25
PL
Celem artykułu jest sprawdzenie czy informacje na temat raka jelita grubego dostępne na najczęściej odwiedzanych stronach internetowych są zrozumiałe dla czytelników czy też, z uwagi na duże nasycenie terminami specjalistycznymi, informacje te są poza poziomem czytelności rekomendowanym dla przeciętnego użytkownika internetu. W analizie zastosowano dwa kryteria opisu: czytelność i trudność leksykalną. Metody badawcze polegały na wykorzystaniu 8 testów na czytelność (ARI, Colemen-Liau, New Dale-Chall, Flesch-Kincid, Fry, GunningFog, RaygorEstimate, SMOG) oraz kilku programów komputerowych, w tym TAALES i LexicalComplexityAnalyser do analizy syntaktycznych i leksykalnych cech tekstu oraz program VocabProfile, dostępny w internecie program oparty na analizie korpusowej pozwalający przeanalizować trudność leksykalną. Badanie wykazało, że wysoka wartość trudności leksykalnej skorelowana jest z poziomem czytelności.
EN
The aim of this paper is to check whether the information for colon cancer patients available on top websites devoted to this disease is comprehensible for the readers or whether, due to high saturation with special medical terms, it is beyond the recommended readability level of an average internet user. Two main criteria of analysis were involved in the study: readability and lexical sophistication. The methods used in the study include 8 readability tests (ARI, Colemen-Liau, New Dale-Chall, Flesch-Kincid, Fry, Gunning Fog, Raygor Estimate, and SMOG), TAALES software and Lexical Complexity Analyser used to examine syntactic and lexical parameters of texts, and a corpus-assisted web-based tool used for lexical sophistication called VocabProfile. The study has shown that none of the 30 websites under scrutiny meets the demand of the recommended readability level, and that higher lexical sophistication involves a lower readability level.
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