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Dostępność, jakość i finansowanie diagnostyki laboratoryjnej - ważne źródło informacji medycznej

100%
Gniadek L.
Kontrola Państwowa
|
2018
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vol. 63
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issue 2 (379)
43-59
XX
Laboratory tests are the cheapest and easily accessible source of medical information about a patient. Although they make an important and frequently decisive element of the diagnostic and therapeutic process, the expenditure on tests in Poland is many times lower than that in other countries of the European Union. The Supreme Audit Office, in accordance with its work plan and guided by the suggestions of the Parliamentary Health Committee, has conducted an audit to evaluate the organisation, quality, access to and financing of the activities related to laboratory diagnostics. The audit comprised: the Ministry of Health, medical entities and laboratory diagnostics subcontractors, including medical diagnostic laboratories in six regions of Poland.
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Haematological changes and metabolic alterations in SARS-CoV-2 infected patients hospitalised at an Infectious Diseases Center, Ibadan, Nigeria

100%
Alonge O., Arinola G.
European Journal of Clinical and Experimental Medicine
|
2022
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issue 4
383-390
EN
Introduction and aim. Following the use of repurposing drugs to successfully manage coronavirus disease 2019 (COVID-19) patients in an Infectious Diseases Center (IDC) in Nigeria, it was imperative to assess haematological changes and metabolic alterations in these patients which may inform recommendations for future use. Material and methods. Blood samples of admitted COVID-19 Nigerian patients during therapeutic management were analysed for haematological- (total white blood cells (WBC), lymphocyte, monocyte, neutrophil, eosinophil, basophil and neutrophil:lymphocyte ratio) and blood chemistry- parameters [total protein, total and conjugated bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), gamma-glutamyl transferase (GGT), albumin, urea, creatinine, total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), PO₄³⁻, Ca²⁺, uric acid, Na⁺, K⁺, Cl⁻ and HCO₃⁻] using autoanalysers. The percentages of patients having values below, within and above reference ranges were compared using Chi-square test while the mean values at admission were compared with mean values at discharge using Student t-test. Results. The mean values of total protein, albumin, Na⁺, HCO₃⁻, uric acid, Ca²⁺, WBC, platelets, lymphocytes, eosinophils and basophils were significantly increased in COVID-19 patients at discharge compared with COVID-19 patients at admission. Also, more percentages of COVID-19 patients at discharge compared with COVID-19 patients at admission had albumin, ALP, total bilirubin, HDL, Na⁺, K⁺, Cl⁻, HCO₃⁻, urea, creatinine, WBC, lymphocytes, neutrophils, monocytes, eosinophils and basophils within normal reference intervals. Conclusion. This study showed that most metabolic and haematological derangements were normalised by repurposing drugs in most of the COVID-19 patients at this IDC, thus supporting the continuous use of this therapeutic option.
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