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Detection of PRL-3 protein in the preoperative serum of patients with colorectal cancer

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Pryczynicz A., Dymicka-Piekarska V., Niewiarowska K., Gryko M., Niksa M., Hawryluk M., Kemona A., Famulski W.
Progress in Health Sciences
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2013
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vol. 3
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issue 1
49-53
EN
Purpose: The aim of study was to detect PRL-3 protein in sera of patients with colorectal cancer. Methods: The study group consisted of 22 patients with colorectal carcinoma and 10 healthy controls. The serum concentration of PRL-3 protein was evaluated by the ELISA method. Results: In the study group with colorectal cancer, the level of PRL-3 protein in preoperative sera was negative (<0.115ng/ml) in 7 cases while the mean value of PRL-3 concentration was 0.616ng/ml (range 0.206-2.072ng/ml) in 15 patients. No statistically significant differences between the study group and healthy controls were observed. Our data showed that increase in level of PRL-3 protein in sera of patients with colorectal cancer is associated with greater tumor size (p<0.05). Conclusions: PRL-3 protein was found to be present in sera of patients with colorectal cancer. However, our study indicates lack of clinical usefulness of determining the levels of PRL-3 in the sera of patients with colorectal cancer.
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The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients

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Jakubowska K., Pryczynicz A., Dymicka-Piekarska V., Cepowicz D., Jagodzińska D., Lewczuk Ł., Lebelt A., Ozimkiewicz M., Kiszło P., Guzińska-Ustymowicz K.
Progress in Health Sciences
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2016
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vol. 6(1)
40-48
EN
Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, differentiation, viability, migration and invasiveness of cancer cells. The aim of our study was to evaluate the expression of GDF-15 in the tissue and its levels in sera of patients with colorectal cancer. Materials and methods: The level of GDF-15 in the sera of 55 patients diagnosed with colorectal cancer was determined using the ELISA method whereas expression of this protein was performed by immunohistochemical method. Results: The mean value of GDF-15 levels in the sera of patients with colorectal cancer was significantly higher than in healthy control group (p<0.001). The expression of GDF-15 in the tissue was weak, moderate and strong in 23.6%, 15.7% and 60.7% cases, respectively. Statistical analysis showed that the expression of GDF-15 correlated with patients’ age (p<0.005) and non-mucinous type of cancer (p<0.001). The high GDF-15 levels in the serum was associated with tumor size (p<0.01) and distant metastases (p<0.05). Conclusions: According to our results, we postulate that the level of GDF-15 in serum can be use to assess the metastatic behavior of colorectal cancer
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