Metaloproteinaza macierzowa-9 (MMP-9) i jej znaczenie w patogenezie chorob cywilizacyjnych

• Authors: Halina Matsumoto , Anna Podgórska , Marcin Wojnar , Piotr Sserafin

Title variants

EN

MATRIX METALLOPROTEINASE-9 ( MMP-9) AND ITS ROLE IN THE PATHOGENESIS OF THE MOST COMMON CIVILIZATION

• Languages of publication: PL

Abstracts

EN

MMP-9 is a member of a family of proteolytic enzymes, zinc and calcium-dependent, of extracellular matrix(ECM) proteinases. MMP-9 is especially active in the degradation of type IV collagen, the main constitutent of the basement membrane and also in degradation of the most of extracellular matrix proteinases . MMP-9 also cleave a variety of non-ECM proteins, such as: cytokines, chemokines and growth factors. Its expression was shown in macrophages and neurophils. MMP-9 take part in many physiological processes such as apoptosis, angiogenesis, wound healing, migration of cells and plays important roles in various aspects of c.n.s functions: brain development, neuroplasticity and epileptigenesis. MMP-9 and their inhibitors (TIMPs) are involved in various pathological processes contributing in this way to pathogenesis of many diseases, including psychiatric disorders. The paper analyses a number of correlations between MMP-9 serum level and development of civilization diseases like cancer, diabetes, heart diseases and arteriosclerosis. It emphasizes the role of the molecular research in looking for association between MMP-9 polymorphism with civilization diseases.. The paper points to the fact that characterization of polymorphism in MMP-9 gene may explain the pathogenesis of psychiatric diseases : schizophrenia, bipolar affective disorder , alcohol and nicotine dependencies.

Keywords

EN

MMP-METALLOPROTEINASE; ECM- EXTRACELLULAR MATRIX PROTEINASES; CIVILIZATION DISEASES

• Publisher: Interdyscyplinarne Centrum Genetyki Zachowania (ICGZ) Uniwersytetu Warszawskiego
• Journal: Psychologia-Etologia-Genetyka
• Year: 2011
• Volume: 24
• Pages: 63-83

Contributors

author

Halina Matsumoto

• Pracownia Psychofarmakologii, Katedra i Klinika Psychiatryczna WUM, ul. Nowowiejska 27, 00-665 Warszawa, Poland

author

Anna Podgórska

author

Marcin Wojnar

author

Piotr Sserafin