Effects of granulocyte colony-stimulating factor therapy for osteogenesis imperfecta: a case report

• Authors: Paszko-Patej, G , Sienkiewicz, D , Kułak, W , Okurowska-Zawada, B , Wojtkowski, J , Kalinowska, A , Okulczyk, K , Sochoń, K , Dmitruk, E , Mirska, A

Abstracts

EN

Introduction: Osteogenesis imperfecta (OI) is a genetic disorder of increased bone fragility and low bone mass. OI type IV. Materials and methods: We examined the safety and effectiveness of a low dose of analog granulocyte colony-stimulating factor (G-CSF) in a 15-year-old girl OI type IV. G-CSF 5 μg/kg was given subcutaneously, for 5 days/month for 3, 6 and 12 months. Laboratory tests, including blood, biochemical tests were performed, in addition to clinical examination.Results: Clinical examination revealed an increase of muscle strength in the upper and lower limbs between base line and day 6 and 12 months. We found no serious adverse events. Leukocyte levels remained below 38,000/μL. Low dose G-CSF was safe and well tolerated by the patient. Conclusions: A significant increase in muscle strength in this patient may indicate beneficial effects of G-CSF factor in this disorder. These results are inspiring and warrant further studies.

Keywords

EN

Osteogenesis imperfecta; granulocyte colony-stimulating factor; muscle strength

• Publisher: Uniwersytet Medyczny w Białymstoku
• Journal: Progress in Health Sciences
• Year: 2017
• Volume: 7(1)
• Pages: 205-208

Contributors

author

Paszko-Patej, G

author

Sienkiewicz, D

author

Kułak, W

author

Okurowska-Zawada, B

author

Wojtkowski, J

author

Kalinowska, A

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Okulczyk, K

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Sochoń, K

author

Dmitruk, E

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Mirska, A

Identifiers

DOI

10.5604/01.3001.0010.1885