New Delhi Metallo-β-Lactamases – the dawn of a post-antibiotic era?

• Authors: Majewski, P , Sacha, P , Wieczorek, P , Ojdana, D , Michalska, A , Tryniszewska, E

Abstracts

EN

The increasing prevalence of acquired carbapenemases in Gram – negative bacteria is one of the biggest problems in the prevention and therapy of infectious diseases. NDM (New Delhi Metallo--Lactamase) is a recently discovered enzyme which has the ability to hydrolyze all -lactam antibiotics, except aztreonam. Making that scenario more worrisome is the fact that mobile fragments of DNA carrying blaNDM genes, also keeps a number of other genes encoding antibiotic resistance. NDM enzymes are currently present in different species of bacteria all over the world. NDM-producing bacteria are resistant to virtually all available antimicrobial agents except tigecycline, colistine and fosfomycine

Keywords

EN

NDM carbapenemases; characteristics; epidemiology; susceptibility to antibiotics

• Publisher: Uniwersytet Medyczny w Białymstoku
• Journal: Progress in Health Sciences
• Year: 2012
• Volume: 2
• Issue: 2
• Pages: 153-160

Contributors

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Majewski, P

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Sacha, P

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Wieczorek, P

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Ojdana, D

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Michalska, A

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Tryniszewska, E