Preliminary study to explore gene-$\text{PM}_\text{2.5}$ interactive effects on respiratory system in traffic policemen

• Authors: Jinzhuo Zhao , Liang Bo , Changyi Gong , Peng Cheng , Haidong Kan , Yuquan Xie , Weimin Song

Abstracts

EN

Objectives Traffic-related particulate matter (PM) is one of the major sources of air pollution in metropolitan areas. This study is to observe the interactive effects of gene and fine particles (particles smaller than 2.5 μm – $\text{PM}_\text{2.5}$) on the respiratory system and explore the mechanisms linking $\text{PM}_\text{2.5}$ and pulmonary injury. Material and Methods The participants include 110 traffic policemen and 101 common populations in Shanghai, China. Continuous 24 h individual-level $\text{PM}_\text{2.5}$ is detected and the pulmonary function, high-sensitivity C-reactive protein (hs-CRP), Clara cell protein 16 (CC16) and the polymorphism in CXCL3, NME7 and C5 genes are determined. The multiple linear regression method is used to analyze the association between $\text{PM}_\text{2.5}$ and health effects. Meanwhile, the interactive effects of gene and $\text{PM}_\text{2.5}$ on lung function are analyzed. Results The individual $\text{PM}_\text{2.5}$ exposure for traffic policemen was higher than that in the common population whereas the forced expiratory volume in 1 s (FEV₁), the ratio of FEV₁ to forced vital capacity (FEV₁/FVC) and lymphocytes are lower. In contrast, the hs-CRP level is higher. In the adjusted analysis, $\text{PM}_\text{2.5}$ exposure was associated with the decrease in lymphocytes and the increase in hs-CRP. The allele frequencies for NME7 and C5 have significant differences between FEV₁/FVC ≤ 70% and FEV₁/FVC > 70% participants. The results didn’t find the interaction effects of gene and $\text{PM}_\text{2.5}$ on FEV₁/FVC in all the 3 genes. Conclusions The results indicated that traffic exposure to high levels of $\text{PM}_\text{2.5}$ was associated with systemic inflammatory response and respiratory injury. Traffic policemen represent a high risk group suffering from the respiratory injury.

Keywords

EN

inflammation; Fine Particles; traffic workers; respiratory system; single nucleotide polymorphism; SNP

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2015
• Volume: 28
• Issue: 6
• Pages: 971-983

Dates

published

2015

Contributors

author

Jinzhuo Zhao

• Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety)

author

Liang Bo

• Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety)

author

Changyi Gong

• Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety)

author

Peng Cheng

• No. 3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China (Department of Gastroenterology)

author

Haidong Kan

• Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety)

author

Yuquan Xie

• Shanghai Jiao Tong University, Shanghai, China (Department of Cardiology, Xinhua Hospital, School of Medicine)

author

Weimin Song

• Fudan University, Shanghai, China (Department of Environmental Health, School of Public Health, Key Laboratory of Public Health Safety)

Identifiers

DOI

10.13075/ijomeh.1896.00370

Biblioteka Nauki

2177102