Usefulness of biomarkers as intermediate endpoints in health risks posed by occupational lead exposure

• Authors: Andrea Borghini , Emilio Antonio Gianicolo , Maria Grazia Andreassi

Abstracts

EN

The article concerns potential harmful effects of exposure to lead. Although the occurrence of severe lead poisoning has receded in several countries, occupational exposure resulting in moderate and clinically symptomatic toxicity is still common. An earlier and precise characterization of an individual response is obligatory in order to assess the possible risks for human health. Biomarkers may fill important gaps in the path from exposure to a disease. Specifically speaking, emerging (DNA double strand breaks and telomeric DNA erosion) and validated (micronuclei induction and chromosomal aberrations) biomarkers of genotoxicity seem to provide evidence for the assessment of molecular and cellular damage. Moreover, identification of genetic variability with a key role in modulating genotoxic damage may help minimize risks for susceptible subjects. Further investigations are naturally needed to properly define their diagnostic and/or prognostic value as “early warning” signs of a long-term risk for a subsequent clinically overt disease.

Keywords

EN

biomarkers; occupational exposure; lead; individual susceptibility; genotoxic effects; health risk

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2015
• Volume: 29
• Issue: 2
• Pages: 167-178

Dates

published

2016

Contributors

author

Andrea Borghini

• National Research Council, Lecce and Pisa, Italy (Institute of Clinical Physiology)

author

Emilio Antonio Gianicolo

• National Research Council, Lecce and Pisa, Italy (Institute of Clinical Physiology)
• Johannes Gutenberg University, Mainz, Germany (Institute for Medical Biostatistics, Epidemiology and Informatics)

author

Maria Grazia Andreassi

• National Research Council, Lecce and Pisa, Italy (Institute of Clinical Physiology)

Identifiers

DOI

10.13075/ijomeh.1896.00417

Biblioteka Nauki

2177066