Endotoxin exposure and changes in short-term pulmonary function among sewage workers

• Authors: Marcin Cyprowski , Wojciech Sobala , Alina Buczyńska , Irena Szadkowska-Stańczyk

Abstracts

EN

Objectives The inhaled endotoxin is considered as a causative factor in the process of acute bronchial obstruction, which can be measured by a decrease in forced expiratory volume in 1 s (FEV₁). The aim of this study was to assess endotoxin exposure among sewage treatment plant workers (STPW) and its effect on across-shift changes in respiratory airflow. Material and Methods A group of 78 STPW from a large sewage treatment plant was studied. Inhalable dust for endotoxin assessment was collected using personal aerosol samplers. Endotoxin was assayed with the kinetic, chromogenic Limulus amebocyte lysate test. Across-shift spirometric measurements were performed on Mondays, after 2-days absence from work, with the use of portable spirometer. The forced vital capacity (FVC), and FEV₁ parameters were analyzed. Multifactor regression modeling was performed to determine parameters significantly associated with endotoxin exposure. Results The concentration of inhalable dust and endotoxin ranged from 0.01–1.38 mg/m³ and 0.68–214 endotoxin units per cubic meter of air (EU/m³), respectively. Endotoxins were characterized with the skewed distribution (arithmetic mean (AM) = 38.8 EU/m³, geometric mean (GM) = 15.4 EU/m³, geometric standard deviation (GSD) = 4.21). Through the use of multifactor analysis, which excluded the main confounders (inhalable dust and smoking habit) it was found that, despite low levels of endotoxin, it had significant impact on the observed across-shift decline in FEV₁ (p = 0.044). For this parameter, the regression slope was additionally calculated (r = –0.017, p = 0.071). Conclusions Relatively low levels of endotoxin among sewage treatment plant workers may cause small, but significant across-shift declines in FEV₁. The observed relationship was independent of organic dust concentrations and smoking habit. The respiratory protection should be provided for STPW.

Keywords

EN

sewage workers; endotoxin exposure; inhalable dust; smoking; lung function; regression analysis

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2015
• Volume: 28
• Issue: 5
• Pages: 803-811

Dates

published

2015

Contributors

author

Marcin Cyprowski

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental Health Hazards)
• Central Institute for Labour Protection – National Research Institute, Warszawa, Poland (Biohazard Laboratory)

author

Wojciech Sobala

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental Health Hazards)

author

Alina Buczyńska

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental Health Hazards)

author

Irena Szadkowska-Stańczyk

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental Health Hazards)

Identifiers

DOI

10.13075/ijomeh.1896.00460

Biblioteka Nauki

2177186