Geospatial clustering of gastroschisis in Poland: Data from the Polish Registry of Congenital Malformations (PRCM)

• Authors: Anna Materna-Kiryluk , Barbara Więckowska , Katarzyna Wiśniewska , Małgorzata Czyżewska , Urszula Godula-Stuglik , Małgorzata Baumert , Ryszard Margol , Anna Latos-Bieleńska

Abstracts

EN

Objectives The aims of this study were: to evaluate the prevalence of abdominal wall defects in the Polish population, to analyze temporal trends in the prevalence, to identify areas (clusters) of high risk of abdominal wall defects, and to characterize, with respect to epidemiology, children with abdominal wall defects and their mothers in the area defined as a cluster. Material and Methods We used isolated congenital malformations (gastroschisis Q79.3 and omphalocele Q79.2 according to the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10, the extended version)) data reported to the Polish Registry of Congenital Malformations (PRCM) over the years 1998– 2008 based on the population of 2 362 502 live births. We analyzed 11 administrative regions of Poland with complete epidemiologic data. Results Of 11 regions, 2 had a significantly higher standardized prevalence of isolated gastroschisis: Dolnośląskie (1.7/10 000 live births, p = 0.0052) and Śląskie (1.9/10 000 live births, p < 0.0001). Furthermore, within the region of Dolnośląskie, we defined a clear prevalence of the isolated gastroschisis cluster (p = 0.023). We comprehensively examined demographic and socio-economic risk factors for abdominal wall defects in this area, and we found that these factors failed to account for the cluster. Conclusions We identified a distinct prevalence cluster for isolated gastroschisis, although a precise reason for the disease clustering in this region remains unknown. Cluster identification enables more focused research aimed at identification of specific factors with teratogenic effects.

Keywords

EN

gastroschisis; Omphalocele; congenital malformations; scan statistic; spatial and temporal clusters; epidemiology

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2015
• Volume: 29
• Issue: 3
• Pages: 461-470

Dates

published

2016

Contributors

author

Anna Materna-Kiryluk

• Poznan University of Medical Sciences, Poznań, Poland (Department of Medical Genetics)

author

Barbara Więckowska

• Poznan University of Medical Sciences, Poznań, Poland (Department of Computer Science and Statistics)

author

Katarzyna Wiśniewska

• Poznan University of Medical Sciences, Poznań, Poland (Department of Preventive Medicine)

author

Małgorzata Czyżewska

• Wroclaw Medical University, Wrocław, Poland (Department and Clinic of Neonatology)

author

Urszula Godula-Stuglik

• Medical University of Silesia, Katowice, Poland (Department of Pediatrics in Zabrze)

author

Małgorzata Baumert

• Medical University of Silesia, Katowice, Poland (Department of Neonatology)

author

Ryszard Margol

• Poviat Hospital, Nysa, Poland (Neonatal Unit)

author

Anna Latos-Bieleńska

• Poznan University of Medical Sciences, Poznań, Poland (Department of Medical Genetics)

Identifiers

DOI

10.13075/ijomeh.1896.00624

Biblioteka Nauki

2177442