A retrospective observational study on patients intoxicated by drugs and other xenobiotics

• Authors: Ewa Sawicka , Paulina Kartuszyńska , Halina Kuczyńska , Agnieszka Piwowar

Abstracts

EN

Objectives Many research studies conducted in various toxicology centers point to drugs as the most common cause of intoxication. Long-term observations make it possible to clarify the nature of these poisonings. The aim of this study was to examine the trends and reasons of intoxication in patients hospitalized over a 10-year observation period (2005–2015), as well as to compare the number of patients poisoned with nonsteroidal anti-inflammatory drugs (NSAIDs), mainly over-the-counter (OTC) drugs. Material and Methods A retrospective observational study examined the medical documentation of patients hospitalized in the Department of Toxicology and Internal Diseases of the T. Marciniak Lower Silesian Specialist Hospital in Wrocław in 2005–2015, including the analysis of the causes of intoxication as well as total poisoning-related death statistics. Quarterly and annual analyses of the numerical data, and comparisons of the frequency of poisonings were included. The patient population from the area of Lower Silesia, Poland, was examined. Results The number of hospitalized patients has increased, with attempted suicide being the leading cause of death. Male intoxication and mortality have been found to predominate. Drugs are the most common cause of poisoning, and among these the most common are sedatives and psychotropic drugs. Intoxication due to NSAIDs, especially OTC drugs, increased significantly in the observation period. In 2005 no fatal cases were reported as a result of NSAID intoxication, while in 2015 mortality significantly increased to 43%. Conclusions The lack of a common trend in poisonings is observed but the number of hospitalized patients has increased, especially among young people, which is consistent with global trends. Drugs are the most common cause of mortality, and a significant increase in NSAID (mainly OTC) poisonings in particular indicates the growing prevalence of an uncontrolled use of these drugs. Int J Occup Med Environ Health. 2019;32(4):489–501

Keywords

EN

alcohol; drugs; carbon monoxide; pesticides; intoxication; retrospective observation

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2019
• Volume: 32
• Issue: 4
• Pages: 489-501

Dates

published

2019

Contributors

author

Ewa Sawicka

• Wroclaw Medical University, Wrocław, Poland (Faculty of Pharmacy with Division of Laboratory Diagnostics, Department of Toxicology)

author

Paulina Kartuszyńska

• Wroclaw Medical University, Wrocław, Poland (Students Science Club of Department of Toxicology)

author

Halina Kuczyńska

• Wroclaw Medical University, Wrocław, Poland (Students Science Club of Department of Toxicology)

author

Agnieszka Piwowar

• Wroclaw Medical University, Wrocław, Poland (Faculty of Pharmacy with Division of Laboratory Diagnostics, Department of Toxicology)

Identifiers

DOI

10.13075/ijomeh.1896.01344

Biblioteka Nauki

2161962