Analytically confirmed presence of psychoactive substances, especially new psychoactive substances in a group of patients hospitalized with mental and behavioural disorders due to the use of psychoactive substances diagnosis

• Authors: Piotr Engelgardt , Maciej Krzyżanowski , Przemysław Piotrowski , Malgorzata Borkowska-Sztachańska , Agnieszka Wasilewska

Abstracts

EN

ObjectivesThe study assessed the presence of new psychoactive substances (NPS) in comparison to “classic” drugs in the group of newly admitted patients with mental and behavioral disorders due to the use of psychoactive substances diagnosis (section F11–19 according to ICD-10).Material and MethodsData from anamnesis and the blood and urine samples were collected from 116 patients diagnosed with mental and behavioral disorders due to psychoactive substance use. All of them expressed written informed consent. Analytical confirmation was obtained by highperformance liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS). Liquid-liquid extraction was used for sample preparation.ResultsIn the sample, 108 (93%) of 116 were positive for psychoactive substances (including 96 cases where >1 substance was found), 69% of individuals were tested positive for opioids and 67% for benzodiazepines. Eleven (9%) of 116 patient samples were positive for NPS. We detected 7 different substances. Six of them were synthetic cannabinoids: PB-22, MDMB-CHMICA, MMB-CHMICA, AB-CHMINACA, MMB-FUBINACA, THJ-2201 and one synthetic cathinone 3-CMC.ConclusionsThe prevalence and NPS profile (the predominance of synthetic cannabinoids) are similar in the group of people with addiction to psychoactive substances as in populations of people taking recreational drugs and the overdose patients admitted to the hospital.

Keywords

EN

THC; epidemiology; addiction; new psychoactive substances; opioids; amphetamine

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2022
• Volume: 35
• Issue: 4
• Pages: 485-495

Dates

published

2022

Contributors

author

Piotr Engelgardt

• University of Warmia and Mazury, Olsztyn, Poland (Faculty of Medicine, Department of Pathomorphology and Forensic Medicine)

author

Maciej Krzyżanowski

• University of Warmia and Mazury, Olsztyn, Poland (Faculty of Medicine, Department of Pathomorphology and Forensic Medicine)

author

Przemysław Piotrowski

• University of Warmia and Mazury, Olsztyn, Poland (Faculty of Medicine, Department of Pathomorphology and Forensic Medicine)

author

Malgorzata Borkowska-Sztachańska

• University of Warmia and Mazury, Olsztyn, Poland (Faculty of Medicine, Department of Psychiatry)

author

Agnieszka Wasilewska

• University of Warmia and Mazury, Olsztyn, Poland (Faculty of Medicine, Department of Psychiatry)

Identifiers

DOI

10.13075/ijomeh.1896.01863

Biblioteka Nauki

2085718