Impact of chemotherapy on antioxidant micronutrient levels in patients with mature lymphoid malignancies

• Authors: Chima Uzoma Akunwata , John Ayodele Olaniyi

Abstracts

EN

Introduction. Cancer treatments are now intense and are associated with nutritional deficiencies. The nutritional status of a patient may influence the tolerability of chemotherapy. Aim. We investigated the effects of chemotherapy on serum levels of trace elements (copper, iron, manganese, selenium, and zinc) and vitamins (A, C, and E) in patients with mature lymphoid malignancies (MLMs) at diagnosis and after 3 months. Material and methods. A case-control study of adults diagnosed with and treated for various MLMs. Thirty-nine cases and 39 age and sex-matched controls were recruited into this study. Venous blood samples were collected from the controls, cases at baseline and after 3 months of chemotherapy. Trace elements were determined by AAS while vitamins were determined by HPLC. Results. The levels of trace elements and antioxidant vitamins A and E were significantly higher (p<0.001) in cases than in controls while vitamin C was lower in cases compared to controls (p=0.005). After 3 months of treatment, 28 patients were available for analysis. There was a significant decline (p<0.001) in all the levels of trace elements and vitamins after chemotherapy. Conclusion. Chemotherapy is associated with a significant reduction in antioxidants levels in patients with MLMs.

Keywords

EN

antioxidant micronutrients; chemotherapy; haematologic malignancies

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2021
• Issue: 3
• Pages: 209-214

Dates

published

2021

Contributors

author

Chima Uzoma Akunwata

• Department of Haematology and Blood Transfusion, University College Hospital, Ibadan, Nigeria

author

John Ayodele Olaniyi

• Department of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria

Identifiers

DOI

10.15584/ejcem.2021.3.1

Biblioteka Nauki

2040176