Oxidative and nitrosative stress in patients with meningitis

• Authors: Emine Siber Namiduru , Mustafa Namiduru , İlkay Karaoğlan , Kübra Koçak

Abstracts

EN

Introduction and aim. Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known as the meninges. In this study, oxidative and nitrosative stress were evaluated in cerebrospinal fluid (CSF) and blood samples that were taken from patients with meningitis. Our goal was to identify a fast and a reliable biomarker using these parameters in order to the early diagnose of bacterial meningitis. Material and methods. In this study, 37 bacterial meningitis, 30 tuberculous meningitis and 30 viral meningitis cases were included. Serum/CSF total oxidant status (TOS) and total antioxidant status (TAS) were measured by the Erel method. Nitrotyrosine concentrations were quantified by using ELISA in both serum and CSF. Results. Serum nitrotyrosine, CSF TAS and TOS levels were not significantly different in three groups (p>0.05). CSF nitrotyrosine levels were significantly higher in bacterial meningitis than tuberculous meningitis group (p<0.05). Viral meningitis patients had higher serum TOS and TAS concentrations than tuberculous meningitis group (p<0.05). Conclusion. As a result, we can say that the oxidative and nitrosative stress markers studied are not a rapid and reliable biomarker in bacterial meningitis’s diagnosis.

Keywords

EN

bacterial meningitis; oxidative stress; nitrotyrosine; tuberculous meningitis; viral menengitis

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2022
• Issue: 1
• Pages: 70-74

Dates

published

2022

Contributors

author

Emine Siber Namiduru

• Department of Nutrition and Dietetics, Faculty of Health Sciences, University of Gaziantep, Gaziantep, Turkey

author

Mustafa Namiduru

• Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey

author

İlkay Karaoğlan

• Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey

author

Kübra Koçak

• Department of Infectious Disease, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey

Identifiers

DOI

10.15584/ejcem.2022.1.10

Biblioteka Nauki

2049160