Correlation between rheumatoid arthritis and periodontitis

• Authors: Anna Zielińska , Jacek Tabarkiewicz

Abstracts

EN

Introduction and aim. The association between periodontitis (PD) and rheumatoid arthritis (RA) has been analyzed and described in literature. Periodontal pathogens, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans are pointed as the common factors for both diseases. In this work we demonstrate that treatment of dental and oral diseases is an unconditional requirement for patients with RA. Material and methods. PubMed was searched with the keyword “rheumatoid arthritis” and “periodontitis” from May 1999 to January 2022, showed 181 articles. Ultimately 72 articles were included in the review. Analysis of the literature. The above mentioned pathogens exhibit multiple mechanisms that disturb immune and inflammatory responses of the human organism. Those mechanisms lead to the periodontal disease (PD) that may activate the systematic reactions which in turn lead to intensification of systematic diseases such as rheumatoid arthritis (RA). P. gingivalis has the ability to expresses PAD enzyme (peptidylarginine deiminase) and activates the citrullization process. Moreover, the bacterium produces gingipain cysteine proteinases, which degrade the mechanisms of immunological system. The latter pathogen, A. actinomycetemcomitans, expresses hypercitrullization in neutrophils. Conclusion. Both pathogens influence inflammatory response of the organism, through the common pro-inflammatory mediators for periodontitis and rheumatoid arthritis, intensify the clinical manifestations of both diseases.

Keywords

EN

Aggregatibacter actinomycetemcomitans; periodontitis; Porphyromonas gingivalis; rheumatoid arthritis; risk factors

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2022
• Issue: 4
• Pages: 451-458

Dates

published

2022

Contributors

author

Anna Zielińska

• Department of Maxillofacial Surgery, Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland

author

Jacek Tabarkiewicz

• Department of Human Immunology, Institute of Medical Sciences, Medical College, University of Rzeszow, Rzeszow, Poland

Identifiers

DOI

10.15584/ejcem.2022.4.11

Biblioteka Nauki

2216798