Role of healthcare professionals in drug-drug interactions and clinical interventions

• Authors: Durr-e-Shahwar Siddiqui

Abstracts

EN

Introduction and aim. Healthcare professionals including prescribers, pharmacists and nurses must have adequate knowledge of drug-drug interactions because they can cause toxicity, loss of efficacy, and side effects. This study was aimed to assess the respective roles of healthcare professionals in preventing drug-drug interactions by clinical interventions. Material and methods. This study was conducted at a Secondary Care Hospital of Pakistan in which total 1000 prescriptions were assessed for drug-drug interactions. Questionnaires and descriptive statistics were tools to assess the satisfaction of prescribers with pharmacists and their own prescribed medications before and after the clinical interventions. Modifications in medication therapies were done accordingly after the evaluation and acceptance of interventions. Results. The p-value was highly significant (p<0.05) which showed that the collaboration between healthcare professionals is necessary to avoid drug-drug interaction by clinical interventions. Acceptance rate of interventions was 77%. Clinical interventions are a useful tool in minimizing and preventing drug-drug interactions. The compliance of prescribers with their own prescribed medication regimens increased after clinical interventions. Conclusion. Prescribers, pharmacists and nurses have their respective roles in preventing drug-drug interactions and they must review the appropriateness of every medication order for clinical interventions.

Keywords

EN

clinical interventions; drug-drug interactions; healthcare professionals

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2023
• Issue: 1
• Pages: 81-89

Dates

published

2023

Contributors

author

Durr-e-Shahwar Siddiqui

• Supervisor Pharmacist, Al-Khidmat Pharmacy Services, Karachi, Pakistan

• https://orcid.org/0000000314489970

References

• U.S. Food and Drug Administration. Drug Interactions: What You Should Know, 2013. Available from: https:// www.fda.gov/drugs/resources-you-drugs/drug-interactions-what-you-should-know. Accessed January 18, 2023.
• Gujjarlamudi HB. Polytherapy and drug interactions in elderly. J Midlife Health. 2016; 7(3):105-107. doi:10.4103/0976-7800.191021.
• Palleria C, Di Paolo A, Giofrè C, et al. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci. 2013;18(7):601-610.
• Tannenbaum C, Sheehan NL. Understanding and preventing drug–drug and drug–gene interactions. Expert Rev Clin Pharmacol. 2014;7(4):533-544. doi: 10.1586/17512433.2014.910111.
• Doan J, Jakubiak HZ, Roy J, Turgeon J, Tannenbaum C. Prevalence and Risk of Potential Cytochrome P450– Mediated Drug-Drug Interactions in Older Hospitalized Patients with Polypharmacy. Ann Pharmacother. 2016;47(3):324-332. doi: 10.1345/aph.1R621.
• Monte AA, Heard KJ, Campbell J, Hamamura D, Weinshilboum RM, Vasiliou V. The Effect of CYP2D6 Drug– Drug Interactions on Hydrocodone Effectiveness. Acad Emerg Med. 2014;21(8):879-885. doi: 10.1111/acem.12431.
• Karahan A, Isik SA, Kav S, Abbasoglu A. Oncology nurses awareness of drug interactions. Asia Pac J Oncol Nurs, 2015;2(4): 271-275. doi: 10.4103/2347-5625.164998.
• Sobrinho NP, Campos JF, Silva RC. Drug scheduling by nurses and drug interactions in patients with cardiovascu88 European Journal of Clinical and Experimental Medicine 2023; 21 (1): 81–89 lar diseases. Rev Bras Enferm. 2020;73(5):e20190307. doi: 10.1590/0034-7167-2019-0307.
• Rivkin A, Yin H. Evaluation of the role of the critical care pharmacist in identifying and avoiding or minimizing significant drug-drug interactions in medical intensive care patients. J Crit Care Med. 2011;26(1):104.e1-6. doi: 10.1016/j.jcrc.2010.04.014.
• Saverno KR, Hines LE, Warholak TL, et al. Ability of pharmacy clinical decision-support software to alert users about clinically important drug-drug interactions. J Am Med Inform Assoc. 2011;18(1):32-37. doi: 10.1136/ jamia.2010.007609.
• Bagri H, Dahri K, Legal M. Hospital Pharmacists’ Perceptions and Decision-Making Related to Drug-Drug Interactions. Can J Hosp Pharm. 2019;72(4):288-294. doi: 10.4212/cjhp.v72i4.2915.
• Synder BD, Polasek TM, Doogue MP. Drug interactions: principles and practice. Aust Prescr. 2012;35(3):85-88. doi: 10.18773/austpresc.2012.037.
• Smithburger PL, Buckley MS, Beijan S, Burenheide K, Kane-Gill SL. A critical evaluation of clinical decision support for the detection of drug–drug interactions. Expert Opin Drug Saf. 2011;10(6):871-882. doi: 10.1517/14740338.2011.583916.
• Aghajani MH, Sistanizad M, Abbasinazari M, et al. Potential Drug-drug Interactions in Post-CCU of a Teaching Hospital. Iran J Pharm Res. 2013;12(1) 243-248. doi: 10.22037/IJPR.2012.1221.
• Kulkarni V, Bora SS, Sirisha S, Saji M, Sundran S. A study on drug–drug interactions through prescription analysis in a South Indian teaching hospital. Ther Adv Drug Saf. 2013;4(4):141-1463. doi: 10.1177/2042098613490009.
• Magro L, Moretti U, Leone R. Epidemiology and characteristics of adverse drug reactions caused by drug–drug interactions. Expert Opin Drug Saf. 2012;11(1):83-94. doi: 10.1177/2042098613490009.
• Kafeel H, Rukh R, Qamar H, et al. Possibility of Drug-Drug Interaction in Prescription Dispensed by Community and Hospital Pharmacy. Pharmacology & Pharmacy. 2014;5(4):401-407. doi: 10.4236/pp.2014.54048.
• Moura CS, Prado NM, Belo NO, Acurcio FA. Evaluation of drug–drug interaction screening software combined with pharmacist intervention. Int J Clin Pharm. 2012;34:547552. doi: 10.1007/s11096-012-9642-2.
• Ismail M, Iqbal Z, Khattak MB, et al. Potential drug–drug interactions in internal medicine wards in hospital setting in Pakistan. Int J Clin Pharm. 2013;35:455-462. doi: 10.1007/s11096-013-9764-1.
• Pitman SK, Hoang UTP, Wi CH, Alsheikh M, Hiner DA, Percival KM. Revisiting Oral Fluoroquinolone and Multivalent Cation Drug-Drug Interactions: Are They Still Relevant? Antibiotics (Basel). 2019;8(3):108. doi: 10.3390/ antibiotics8030108.
• Hoffelt C, Gross T. A review of significant pharmacokinetic drug interactions with antidepressants and their management. Ment Health Clin. 2016;6(1):35-41. doi: 10.9740/ mhc.2016.01.035.
• Mistry SD, Trivedi HR, Paramar DM, Dalvi PS, Jiyo C. Impact of proton pump inhibitors on efficacy of clopidogrel: Review of evidence. Indian J Pharmacol. 2011;43(2):183186. doi: 10.4103/0253-7613.77360.
• Quintero GC. Review about gabapentin misuse, interactions, contraindications and side effects. J Exp Pharmacol. 2017;9:13-21. doi: 10.2147/JEP.S124391.
• Amare F, Gashaw T, Sisay M, Baye Y, Tesfa T. The appropriateness of ceftriaxone utilization in government hospitals of Eastern Ethiopia: A retrospective evaluation of clinical practice. SAGE Open Med. 2021;9. doi: 10.1177/20503121211051525.
• Case Report. Alprazolam/fluconazole. Reactions Weekly. 2015;1557:24. doi:10.1007/s40278-015-2774-0.
• Thomas L, Birangal SR, Rao M. Prediction of potential drug interactions between repurposed COVID-19 and antitubercular drugs: an integrational approach of drug information software and computational techniques data. Ther Adv Drug Saf. 2021;12. doi: 10.1177/20420986211041277.
• Miljkovic V, Arsic B, Bojanic Z, et al. Interactions of metronidazole with other medicines: a brief review. Pharmazie. 2014,69:571-577. doi: 10.1691/ph.2014.3951.
• Cascorbi I. Drug Interactions-Principles, Examples and Clinical Consequences. Dtsch Arztebl Int. 2012;109(3334):546-556. doi: 10.3238/arztebl.2012.0546.
• Roblek T, Deticek A, Leskovar B, et al. Clinical-pharmacist intervention reduces clinically relevant drug–drug interactions in patients with heart failure: A randomized, double-blind, controlled trial. Int J Cardiol. 2016;203:647652. doi: 10.1016/j.ijcard.2015.10.206.
• Muylle KM, Gentens K, Dupont AG, Cornu P. Evaluation of an optimized context-aware clinical decision support system for drug-drug interaction screening. Int J Med Inform. 2021;148:104393. doi: 10.1016/j.ijmedinf.2021.104393.
• Moore N, Pollack C, Butkerait P. Adverse drug reactions and drug–drug interactions with over-the-counter NSAIDs. Ther Clin Risk Manag. 2015;11:1061-1075. doi: 10.2147/TCRM.S79135.
• Leeuwen RWF, Jansman FGA, Bemt PMLA, et al. Drug– drug interactions in patients treated for cancer: a prospective study on clinical interventions. Ann of Oncol. 2015;26(5):992-997. doi: 10.1093/annonc/mdv029.
• Langness JA, Nguyen M, Wieland A, Everson GT, Kiser JJ. Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions. World J Gastroenterol. 2017;23(9):1618-1626. doi: 10.3748/wjg.v23.i9.1618.
• Dixon TGK, Williams MG, Hall J, Brown BA. The prevalence of major potential drug-drug interactions at a University health centre pharmacy in Jamaica. J Pharm Pract. 2015;13(4):601. doi: 10.18549/PharmPract.2015.04.601. 89Role of healthcare professionals in drug-drug interactions and clinical interventions
• McQuade BM, Campbell A. Drug Prescribing: Drug-Drug Interactions. FP Essent. 2021;508:25-32.
• Vazquez SR. Drug-drug interactions in an era of multiple anticoagulants: a focus on clinically relevant drug interactions. Blood. 2018;132(21):2230-2239.doi: 10.1182/blood-2018-06-848747.
• Hussain IM, Reynolds TL, Zheng K. Medication safety alert fatigue may be reduced via interaction design and clinical role tailoring: a systematic review. J Am Med Inform Assoc. 2019;26(10):1141-1149. doi: 10.1093/jamia/ocz095.
• Schwappach DLB, Pfeiffer Y, Taxis K. Medication double-checking procedures in clinical practice: a cross-sectional survey of oncology nurses’ experiences. BMJ Open. 2016;6(6):e011394. doi: 10.1136/bmjopen-2016-011394.
• Tannir MA, AlGahtani F, Shaheen AA, Tannir SA, AlFayyad I. Patient experiences of engagement with care plans and healthcare professionals’ perceptions of that engagement. BMC Health Serv Res. 2017;17:853. doi: 10.1186/ s12913-017-2806-y.
• Baetselier ED, Dilles T, Feyen H, Mortelmans L, Rompaey BN. Nurses’ responsibilities and tasks in pharmaceutical care: A scoping review. Nursing Open. 2021;9(6):25622571. doi: 10.1002/nop2.984.

Identifiers

DOI

10.15584/ejcem.2023.1.11

Biblioteka Nauki

2211406