Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction

• Authors: Emmanuel Akokhamen Omon , Olawale David Ajay

Abstracts

EN

Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.

Keywords

EN

antioxidants; dysfunction; malondialdehyde; oxidative stress; thyroid hormone

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2023
• Issue: 4
• Pages: 768-775

Dates

published

2023

Contributors

author

Emmanuel Akokhamen Omon

• Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti, Ekiti State, Nigeria

author

Olawale David Ajay

• University Health Center, Bamidele Olumilua University of Education, Science and Technology Ikere, Ekiti State, Nigeria

Identifiers

DOI

10.15584/ejcem.2023.4.18

Biblioteka Nauki

29520465