Therapeutic advantages of omega-3 fatty acid supplementation in patients with schizophrenia – a systematic review

• Authors: Srilaxmi Vityala , Krishna Priya Kanteti , Yethindra Vityala , Tugolbai Tagaev , Ujwala Damineni

Abstracts

EN

Introduction and aim. In patients with schizophrenia, omega-3 (n-3) polyunsaturated fatty acids (PUFAs) treatment was found to ameliorate the cardiovascular, metabolic, and inflammatory problems caused by antipsychotic medication and even reduce the need for medication by 20%. In this study, we evaluated the potential therapeutic effects of n-3 PUFA supplementation in patients with schizophrenia. Material and methods. The PRISMA guidelines were followed in conducting this systematic review. The Embase, MEDLINE, Web of Science, and Google Scholar databases were searched electronically. The first search yielded 50 papers in total. Subsequently, 43 publications that did not meet our eligibility requirements were removed, and seven articles were selected. Analysis of the literature. The analysis showed that n-3 PUFA supplementation and the placebo group both decreased their psychotic (PANSS and GAF scales) and Calgary Depression Scale symptomatology and boosted their functional ability (GAF) when used as an adjuvant to antipsychotic medication. When administered as a monotherapy with a metabolic antioxidant, n-3 PUFA supplementation proved beneficial for treating schizophrenia. In patients with schizophrenia, n-3 PUFAs have therapeutic benefits as adjuvant treatments to medications, although not for different variables or patient groups. Conclusion. In many studies, patients with chronic schizophrenia who received n-3 PUFA supplementation showed no improvement in their clinical condition.

Keywords

EN

docosahexaenoic acid; eicosapentaenoic acid; omega-3 polyunsaturated fatty acids; schizophrenia; supplementation

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2024
• Volume: 22
• Issue: 1
• Pages: 172-178

Dates

published

2024

Contributors

author

Srilaxmi Vityala

• College of Fishery Science, Wanaparthy, Telangana, India

author

Krishna Priya Kanteti

• Gandhi Medical College and Hospital, Secunderabad, Telangana, India

author

Yethindra Vityala

• Department of Pathology, International Higher School of Medicine, Bishkek, Kyrgyzstan

author

Tugolbai Tagaev

• Department of Public Health and Health care, I. K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

author

Ujwala Damineni

• Maheshwara Medical College and Hospital, Hyderabad, Telangana, India

Identifiers

DOI

10.15584/ejcem.2024.1.5

Biblioteka Nauki

40499950