A well-oxygenated cells environment may help to fight against protein glycation

• Authors: Béatrice Mercier , Josiane Prost , Michel Prost

Abstracts

EN

Objectives: Normoglycemic Wistar rats’ Glycated Hemoglobin Levels (GHL) showed a time-dependent difference between control groups and those exposed to regular inhalation of peroxidizing extracts of turpentine. These extracts were able to optimize the oxygen permeation at the cellular level during and subsequently to a breathing session. The more the rats breathed turpentine peroxidized vapor, the lower their GHL was. This study was designed to confirm, in ex-vivo blood samples, the impact of peroxidizing extract on the GHL. Materials and Methods: Red blood cells were separated from plasmas by centrifugation. Plasmas were treated by peroxidizing and non-peroxidizing turpentine vapor or untreated (control), then combined with washed red blood cells three hours before evaluation. Glycation of hemoglobin proteins was quantified according to the Habeed’s method. Results: The ex-vivo experiments showed that the peroxidizing terpenes reduced the GHL after a three-hour contact. So did oxidized terpenes. Controls and the volatile component of the expended essential oil showed the opposite results. Conclusion: Optimal oxygenation, especially when facilitated by the peroxidized volatile component of the essential oil of turpentine, can protect organisms (mammals in this study) from protein glycation. Optimizing oxygenation can also reduce the GHL of treated blood samples after three hours of incubation.

Keywords

EN

Bol d’Air Jacquier®; peroxidizing terpenes; glycated hemoglobin; oxygen

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2011
• Volume: 24
• Issue: 1
• Pages: 102-107

Dates

published

2011

Contributors

author

Béatrice Mercier

• Faculté des Sciences de la Vie, UPRES EA 4183 “Lipides & Signalisation Cellulaire”, Université de Bourgogne, Dijon, France

author

Josiane Prost

• Faculté des Sciences de la Vie, UPRES EA 4183 “Lipides & Signalisation Cellulaire”, Université de Bourgogne, Dijon, France

author

Michel Prost

• Lara-Spiral SA, Couternon, France

Identifiers

DOI

10.2478/s13382-011-0005-3

Biblioteka Nauki

2185469