Influence of acetylsalicylic acid on hematotoxicity of benzene

• Authors: Joanna Kowalówka-Zawieja , Barbara Zielińska-Psuja , Jędrzej Przystanowicz , Karina Sommerfeld

Abstracts

EN

Objectives: The aim of the study was to evaluate the influence of acetylsalicylic acid (ASA) on benzene hematotoxicity in rats. Materials and Methods: The study was carried out on rats exposed for 2, 4 and 8 weeks to benzene vapour at a conentration of 1.5 or 4.5 mmol/m³ of air (5 days per week, 6 hours per day) alone or together with ASA at the doses of 5, 150 or 300 mg/kg body weight (per os). Results: Benzene at a concentration of 4.5 mmol/m³ caused a slight lymphopenia, granulocytosis and reticulocytosis in blood. In bone marrow traits of megaloblastic renewal, presence of undifferentiated cells and giant forms of granulocytes as well as an increase in myeloperoxidase and decrease in chloroacetate esterase activity and lipids content were noted. ASA (150 and 300 mg/kg b.w.) influenced some of hematological parameters, altered by benzene intoxication. ASA limited the solvent-induced alteration in blood reticulocyte count and in the case of bone marrow in the erythroblasts count. Traits of megaloblastic renewal in bone marrow were less pronounced. Besides, higher activity of myeloperoxidase and the decrease in the level of lipids in granulocytes were noted. Conclusion: Our results suggest that ASA limited the benzene-induced hematotoxicity.

Keywords

EN

benzene; acetylsalicylic acid; interactions; hematotoxicity; blood; bone marrow

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2013
• Volume: 26
• Issue: 5
• Pages: 802-812

Dates

published

2013

Contributors

author

Joanna Kowalówka-Zawieja

• Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland

author

Barbara Zielińska-Psuja

• Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland

author

Jędrzej Przystanowicz

• Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland

author

Karina Sommerfeld

• Department of Toxicology, Poznan University of Medical Sciences, Poznań, Poland

Identifiers

DOI

10.2478/s13382-013-0144-9

Biblioteka Nauki

2179057