Biological effects of molybdenum compounds in nanosized forms under in vitro and in vivo conditions

• Authors: Zuzanna Sobańska , Lidia Zapór , Mateusz Szparaga , Maciej Stępnik

Abstracts

EN

Nanoparticles of transition metal dichalcogenides, particularly of molybdenum (Mo), have gained a lot of focus due to their exceptional physicochemical properties and the growing number of technological applications. These nanoparticles are also considered as potential therapeutic tools, biosensors or drug carriers. It is crucial to thoroughly examine their biocompatibility and ensure safe usage. The aim of this review is to analyze the available data on the biological effects of different nanoforms of elemental Mo and its compounds. In the reviewed publications, different conditions were described, including different experimental models, examined nanoforms, and their used concentrations. Due to these differences, the results are rather difficult to compare. Various studies classify Mo related nanomaterials as very toxic, mildly toxic or non-toxic. Similarly, the mechanisms of toxicity proposed in some studies are different, including oxidative stress induction, physical membrane disruption or DNA damage. Quite promising, however, are the potential medical applications of MoS2 nanoparticles in therapy of cancer and Alzheimer’s disease. Further studies on biocompatibility of nanomaterials based on Mo compounds are warranted.

Keywords

EN

in vitro; nanoparticles; in vivo; molybdenum disulphide; biological effects; molybdenum compounds

• Publisher: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
• Journal: International Journal of Occupational Medicine and Environmental Health
• Year: 2019
• Volume: 33
• Issue: 1
• Pages: 1-19

Dates

published

2020

Contributors

author

Zuzanna Sobańska

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Toxicology and Carcinogenesis)

author

Lidia Zapór

• Central Institute for Labour Protection – National Research Institute, Warsaw, Poland (Laboratory of Toxicology)

author

Mateusz Szparaga

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Toxicology and Carcinogenesis)

author

Maciej Stępnik

• Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Toxicology and Carcinogenesis)

Identifiers

DOI

10.13075/ijomeh.1896.01411

Biblioteka Nauki

2116716