Search results

1

Ovarian cancer and inflammation. Part 2. Anti-inflammatory cytokines

100%

Terlikowska, K.M, Dobrzycka B., Terlikowski S.

Progress in Health Sciences

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2018

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vol. 8(2)

206-209

EN

Inflammation plays a key role in epithelial ovarian cancer tumorigenesis and progression. The growth and progression of epithelial ovarian cancer may be due to local cytokine-induced immunosu-ppression, which may lead to an immunity impairment. Thus, cytokine antagonism may be an essential factor in the treatment of ovarian cancer. Based on the increased knowledge on the role of the immune system in ovarian cancer, major improvements are to be expected of immunotherapy based treatment of this disease. This article aims to summarize the current literature views on the evidence for a role for chronic inflammation with a specific focus on anti-inflammatory cytokines.

2

Effect of regular physical activity on non-lipid (novel) cardiovascular risk factors

100%

Naghii M. R., Aref M. A., Almadadi M., Hedayati M.

International Journal of Occupational Medicine and Environmental Health

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2011

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vol. 24

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issue 4

380-390

EN

Objectives: Cardiovascular - coronary heart disease, causing heart attack and heart failure is a leading cause of disability and death worldwide. The most important risk factors for CVD are well-established and physical activity has long been considered the cornerstone of interventions and has shown extremely important in reducing the burden of this disease. The aim of this study was to examine the association between activity and inactivity and non-lipid CVD risk factors in healthy military recruits. Materials and Methods: Selected hormones and variables such as testosterone, free testosterone, Vitamin D, homocysteine, folic acid, with the inflammatory cytokines such as hsCRP, TNF-α and IL-6 were assessed in two groups (active = 50, inactive = 50), randomly matched by a questionnaire. Relationships between some measured variables and CVD risk factors were determined using simple correlation procedures. Results: Physically active subjects had signifi cantly lower results of homocysteine (14.3±1.9 vs. 16.5±3.7, p < 0.000) and interleukin-6 (2.9.±5.3 vs. 6±8.2, p < 0.025) and tended to have a nearly signifi cantly higher free testosterone level (13.1±7.1 vs. 11±5.3, p = 0.08). Signifi cant correlations were found between BMI, WC, tHcy, and the corresponding risk factors; and also between hsCRP and IL-6, as well as TT and FT. Conclusions: Reducing the risk factors of developing CVD events such as homocysteine and interleukin-6, together with increasing free testosterone and signifi cantly preventing its progression, clearly serve to underscore the benefi cial properties of physical activity and to promote its effectiveness as a support means for healthier lifestyles in the community and, particularly, among military personnel.

3

Ovarian cancer and inflammation. Part 1. Pro-inflammatory cytokines.

100%

Terlikowska K., Strzyż-Skalij M., Kryński K., Osmólska M., Łada Z., Malinowska-Gleń M., Kryńska E., Terlikowski R.

Progress in Health Sciences

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2018

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vol. 8(1)

194-201

EN

Ovarian cancer is the most threatening cause of death among gynecologic malignancies and represents the fifth leading cause of death from all cancers for women. Research reveals that ovarian cancer patients exhibit significant immune responses against the tumor. In this review of the current literature chiefly the interaction of ovarian cancer tumor cells and the immune system is discussed. There is increasingly growing evidence that pro-inflammatory cytokines are involved in intricate complex of mechanisms responsible for tumorigenesis, and delicate balance between pro- and anti-inflammatory cytokines is critical for the antitumor host immune response.

4

Benign endometrial lesions in premenopausal women: three-dimensional power Doppler sonography and cytokines content

88%

Lysenko O.

Progress in Health Sciences

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2013

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vol. 3

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issue 2

11-16

EN

Purpose: To investigate the IL-2, IL-4, IL-6, IL-8, IL-10, TNF-a, IL-1β, IFN-γ at the local and system levels in endometrial polyps and hyperplasia in premenopausal women; to assess whether three-dimensional power Doppler indices can discriminate between hyperplasia and proliferative endometrium. Materials and methods: The prospective analysis included 80 premenopausal women with the suspicion of endometrial hyperplasia and endometrial polyp according to 2D ultrasonography data. Three groups of patients were analyzed according to histological data. There were 25 women with simple endometrial hyperplasia without atypia (the first study group), 15 patients with hyperplastic endometrial polyps (the second study group) and 40 healthy women with endometrium in the early proliferative phase (control group) in premenopausal age. The levels of some cytokines were determined by enzyme linked to immunosorbent assay in serum and in aspirates from the uterus cavity. Three-dimensional power Doppler indexes of the uterus and endometrium were measured in endometrial hyperplasia and proliferative endometrium. Results: Significant dysfunctional changes of local immune system of uterine mucosa in endometrial hyperplasia and endometrial polyp are expressed in activation of pro-inflammatory cytokines, with a deficit of anti-inflammatory cytokines. Endometrial three-dimensional power Doppler indices of uterine and endometrium were significantly higher in endometrial hyperplasia. Conclusions: The local secretion imbalance of pro- and anti-inflammatory cytokines is present in endometrial hyperplasia and polyps in premenopausal age. Endometrial perfusion increases in endometrial hyperplasia by using three-dimensional power Doppler sonography in comparison with healthy women.

5

Immunological determinants in a murine model of toluene diisocyanate-induced asthma

88%

Świerczyńska-Machura D., Walusiak-Skorupa J., Nowakowska-Świrta E., Piasecka-Zelga J., Świercz R., Pałczyński C.

International Journal of Occupational Medicine and Environmental Health

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2012

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vol. 25

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issue 4

492-498

EN

Objectives: Diisocyanates (DIC) are highly reactive, low-molecular-weight chemicals which are the leading cause of occupational asthma (OA). The aim of the study was to analyze certain aspects of the pathogenesis of allergic infl ammation in the airways induced by toluene diisocyanate (TDI) in an experimental model in mice. Materials and Methods: The experiment was carried out on 50 female BALB/cJ/Han/IMP mice, which were exposed by inhalation (intranasal and in the inhalation chamber) to toluene diisocyanate (2,4-TDI). After the experiment, the bronchoalveolar lavage fluid (BALF) was collected from the animals, and the composition of the induced infl ammatory cells, and the concentrations of certain cytokines (IL-4, IL-5, TNF-α) were evaluated. Results: The total number of cells in BALF of the examined group of mice was signifi cantly higher compared to the control mice. There was also a signifi cant increase in neutrophils and eosinophils in the study group compared to the controls. The number of lymphocytes and macrophages did not differ signifi cantly between the two groups. A statistically signifi cant increase in the level of TNF-α was shown to occur in the group exposed to toluene diisocyanate in comparison to the control group. The concentration of IL-4 increased in the study group, compared to the control one, but the differences did not reach the level of signifi cance, p > 0.05. Such difference was not observed for IL-5. Conclusions: We developed a murine model of TDI-induced asthma which caused the infl ux of infl ammatory cells like eosinophils and neutrophils in the bronchoalveolar lavage fl uid (BALF) in the TDI-treated mice. The increase of the concentration of some proinfl ammatory cytokines (TNF-α, IL-4) in BALF from the exposed mice was also observed.

6

Inflammation mediators in employees in chronic exposure to neurotoxicants

88%

Bodienkova G., Alekseev R., Boklazhenko E., Kurchevenko S.

International Journal of Occupational Medicine and Environmental Health

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2014

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vol. 27

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issue 4

619-626

EN

Objectives: The aim of this work is to perform comparative estimation of cytokines levels in chlorinated hydrocarbons and metallic mercury exposure in employees in the dynamics of neurologic disorders formation. Material and Methods: The contents of cytokines IL-1β, IL-2, IL-4, IL-6, TNF-α, INF-γ were determined in blood sera using the method of hardphasic immunoferment analysis. The significance of different average values was assessed using the parametric and non-parametric criteria - Student (in normal distribution) and Mann-Whitney tests taking into account the Bonferonni correction (non-difference from normal distribution). Results: It was shown that, a number of inflammation mediators with the dominance, depending on the expositional toxicant and expression of neurological deficiency, take part in the neurointoxication development. Healthy employees show pro-inflammatory responses with different expression degree, which dominate in the immune regulation processes regardless of the expositional factors (metallic mercury vapors and chlorinated hydrocarbons). Conclusions: The production intensity and interconnection between the pro- and anti-inflammatory cytokines may change in the occupational injuries of the nervous system development process. The decrease in the serum concentrations of cytokines along with the increase of clinical manifestation severity may prove dysregulation of the immune system, which promotes maintaining of pathological process and progradient process of neurointoxication. The most obvious is the imbalance of cytokines in the employees exposed to metallic mercury (in all the examined groups) that increases neurointoxication in the distant period.

7

Effects of work-related sleep restriction on acute physiological and psychological stress responses and their interactions: A review among emergency service personnel

75%

Wolkow A., Ferguson S., Aisbett B., Main L.

International Journal of Occupational Medicine and Environmental Health

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2015

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vol. 28

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issue 2

183-208

EN

Emergency work can expose personnel to sleep restriction. Inadequate amounts of sleep can negatively affect physiological and psychological stress responses. This review critiqued the emergency service literature (e.g., firefighting, police/law enforcement, defense forces, ambulance/paramedic personnel) that has investigated the effect of sleep restriction on hormonal, inflammatory and psychological responses. Furthermore, it investigated if a psycho-physiological approach can help contextualize the significance of such responses to assist emergency service agencies monitor the health of their personnel. The available literature suggests that sleep restriction across multiple work days can disrupt cytokine and cortisol levels, deteriorate mood and elicit simultaneous physiological and psychological responses. However, research concerning the interaction between such responses is limited and inconclusive. Therefore, it is unknown if a psycho-physiological relationship exists and as a result, it is currently not feasible for agencies to monitor sleep restriction related stress based on psycho- physiological interactions. Sleep restriction does however, appear to be a major stressor contributing to physiological and psychological responses and thus, warrants further investigation.

8

Inflammatory response to acute exposure to welding fumes during the working day

75%

Järvelä M., Kauppi P., Tuomi T., Luukkonen R., Lindholm H., Nieminen R., Moilanen E., Hannu T.

International Journal of Occupational Medicine and Environmental Health

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2013

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vol. 26

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issue 2

220-229

EN

Objectives: To investigate cardiorespiratory and inflammatory responses in male workers following exposure to welding fumes and airborne particles in actual workplace conditions. Materials and Methods: We measured blood leukocytes and their differential counts, platelet count, hemoglobin, sensitive C-reactive protein, fibrinogen, E-selectin, IL-(interleukin)1β, IL-6, IL-8, tumor necrosis factor alpha (TNF-α) and endothelin-1 in blood samples of twenty workers before and after their working day. We also studied peak expiratory flow (PEF), forced expiratory volume in one second (FEV₁), and exhaled nitric oxide (NO). We assessed heart rate variability (HRV) by obtaining 24-hour ambulatory electrocardiograms. Results: The total blood leukocytes and neutrophils increased after the work shift, whereas IL-1β and E-selectin decreased significantly. There were no tatistically significant changes in exhaled NO, FEV₁, PEF or HRV. Conclusion: Occupational exposure to welding fumes and particles caused a slight, acute inflammatory effect estimated based on the increased values of leukocytes and neutrophils in blood and a decrease in the interleukin 1β and E-selectin values, but no changes in the pulmonary function (exhaled NO, FEV₁, PEF) or HRV during the working day were observed.

9

Monoinfekcja Borrelia burgdorferi i współzakażenia Borrelia burgdorferi / Anaplasma phagocytophilum u pracowników leśnictwa i rolników

51%

Tokarska-Rodak M., Pańczuk A., Kozioł-Montewka M., Plewik D., Szepeluk A.

Medycyna Pracy

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2015

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vol. 66

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issue 5

645-651

EN

Background The presence of co-infections induced by tick-borne pathogens in humans is an important epidemiological phenomenon. This issue has attracted growing attention of doctors and people working under conditions of an increased risk of being exposed to tick bites. Material and Methods The research group consisted of 93 individuals with current anti-immunoglobulin M/G (IgM/ IgG) Borrelia burgdorferi or IgG anti-Anaplasma phagocytophilum. The respondents were identified during the screening survey in a group of farmers and foresters occupationally exposed to tick bites. The aim of the work was to analyse the frequency of antibodies to specific antigens of B. burgdorferi and the levels of cytokines in forestry workers and farmers with B. burgdorferi monoinfections and B. burgdorferi / A. phagocytophilum co-infections. Statistical analysis was performed using the Chi², Mann-Whitney U and Kruskal-Wallis tests. Results There is a stronger generation of IgG antibodies to B. burgdorferi antigens in patients with B. burgdorferi / A. phagocytophilum co-infections, such as variable major protein-like sequence expressed (VlsE) (p < 0.05), p19 (p < 0.02), p17 (p < 0.05) and complement regulator-acquiring surface protein 3 (CRASP3) (p < 0.02) compared to persons with B. burgdorferi monoinfections. The discrepancies in the synthesis of cytokines interleukin 6 (IL-6), IL-10, and tumor necrosis factor α (TNF-α) have not been found in persons with B. burgdorferi monoinfections and B. burgdorferi / A. phagocytophilum co-infection. Conclusions The immune response directed against B. burgdorferi is stronger in patients co-infected with B. burgdorferi and A. phagocytophilum than in those with monoinfection. Med Pr 2015;66(5):645–651

PL

Wstęp Występowanie u ludzi koinfekcji patogenami przenoszonymi przez kleszcze jest istotnym zjawiskiem epidemiologicznym, któremu coraz więcej uwagi poświęcają zarówno lekarze, jak i osoby pracujące w warunkach zwiększonego ryzyka ukłucia przez kleszcze. Materiał i metody Grupa badana obejmowała 93 osoby z obecnymi przeciwciałami immunoglobuliny M/G (IgM/IgG) anty-Borrelia burgdorferi i IgG anty-Anaplasma phagocytophilum, wyłonione podczas badań przesiewowych z grupy rolników i leśników zawodowo narażonych na pokłucia przez kleszcze. Celem pracy była ocena częstości występowania przeciwciał IgM/IgG dla specyficznych antygenów B. burgdorferi oraz poziomu wybranych cytokin u rolników i leśników w zależności od obecności monoinfekcji B. burgdorferi lub współzakażenia B. burgdorferi / A. phagocytophilum. Uzyskane wyniki badań poddano analizie statystycznej (test Chi², Manna-Whitneya, Kruskala-Wallisa). Wyniki U osób z koinfekcją B. burgdorferi i A. phagocytophilum istnieje silniejsze generowanie przeciwciał IgG dla antygenów B. burgdorferi, takich jak VlsE (variable major protein- like sequence expressed) (p < 0,05), p19 (p < 0,02), p17 (p < 0,05) i CRASP3 (complement regulator-acquiring surface protein 3) (p < 0,02) w porównaniu z osobami z monoinfekcją B. burgdorferi. Nie stwierdza się różnic w poziomie generowanych cytokin interleukiny 6 (IL-6), IL-10, czynnika martwicy nowotworu α (tumor necrosis factor α – TNF-α) u osób z monoinfekcją B. burgdorferi i koinfekcją B. burgdorferi / A. phagocytophilum. Wnioski U pacjentów z jednoczesnym zakażeniem B. burgdorferi i A. phagocytophilum odpowiedź immunologiczna skierowana przeciwko B. burgdorferi jest silniejsza niż w przypadku monoinfekcji. Med. Pr. 2015;66(5):645–651

10

Keloidy – łagodne nowotwory tkanki łącznej powstające w wyniku zaburzeń gojenia

51%

Jurzak M., Goździalska A., Dębska G.

Państwo i Społeczeństwo

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2012

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issue 2

7-19

EN

Keloids are benign dermal fibroproliferative tumors with no malignant potential. Clinically, keloids are defined as scars that invade adjacent healthy tissue and rarely regress over time. These abnormal scars result from the loss of the control mechanisms that normally regulate the fine balance of tissue repair and regeneration. They usually occur during the healing of a deep skin wound. Keloids formation can occur within a year after injury, and keloids enlarge well beyond the original scar margin. The most frequently involved sites of keloids are areas of the body that are constantly subjected to high skin tension. Two factors are generally regarded as key factors for keloid formation: genetic predisposition and skin lesion. Growth factors and cytokines are intimately involved in the cycle of wound healing after skin lesion. Precise mechanism of keloids formation during delayed wound healing process has not been yet established. It may result from abnormal cytokine release, epithelial disruption, excessive matrix deposition, or abnormal remodeling of excessive matrix. Abnormal cytokines have been reported in formation keloids including TGF β, IL-6, CTGF. The formation of the extracellular matrix is carried out by the synthesis of collagen, fibronectin and proteoglycans. A deficient synthesis of products that promote matrix degradation or an excessive matrix synthesis, or both, explain the lack of scar regression in keloids. Collagen degradation is mediated by matrix metalloproteinases (MMPs) and their specific tissue inhibitors TIMPs. Available methods of treatment include surgical treatment, pharmacological treatment and physical treatment. The last of them includes: cryotherapy, laser therapy, pressure therapy and radiotherapy. Any of these could be used alone, but better effects are achieved in combination different form of treatment.

PL

Keloidy są łagodnymi nowotworami skóry bez cech złośliwości. Klinicznie keloidy definiowane są jako blizny charakteryzujące się rozrostem na zdrowe, otaczające tkanki i rzadko ustępują samoistnie. Te nieprawidłowe blizny są efektem zaburzeń mechanizmów fizjologicznie regulujących równowagę podczas naprawy i regeneracji tkanek. Keloidy zwykle są następstwem procesu gojenia ran pełnej grubości skóry. Zmiany te mogą pojawić się nawet po długim czasie od zadziałania czynnika uszkadzającego i zwykle wykraczają poza obszar pierwotnego uszkodzenia skóry. Najczęstszymi lokalizacjami występowania keloidów są okolice ciała o wzmożonym napięciu skóry. Genetycznie uwarunkowane predyspozycje oraz uszkodzenie skóry są czynnikami o kluczowym znaczeniu w rozwoju keloidów. Czynniki wzrostu i cytokiny są zaangażowane w procesy gojenia ran po urazach skóry. Dokładny mechanizm tworzenia keloidów podczas zaburzonego gojenia ran nie jest znany. Jednakże wydaje się, że zaburzenia wydzielania cytokin przez komórki, przerwanie ciągłości naskórka, nadmierna synteza macierzy pozakomórkowej i jej nieprawidłowe remodelowanie, mogą powodować powstawanie tego typu zmian. W formowaniu keloidów szczególną rolę odgrywają transformujący czynnik wzrostu typu β (TGF β), interleukina 6 (IL-6) oraz czynnik wzrostu tkanki łącznej (CTGF). Nieprawidłowa macierz pozakomórkowa blizn keloidowych obfituje w kolageny, fibronektynę i proteoglikany. Niedobór składników macierzy zdolnych do jej degradacji może być przyczyną braku regresji keloidów. Wymiana składników macierzy pozakomórkowej odbywa się z udziałem metaloproteinaz macierzy pozakomórkowej (MMPs) zdolnych do degradacji jej składowych oraz ich specyficznych tkankowych inhibitorów (TIMPs). Dostępnymi metodami leczenia keloidów są leczenie chirurgiczne, farmakologiczne oraz metody fizykalne. Wśród metod fizykalnych stosowane są ostatnio krioterapia, laseroterapia, presoterapia oraz radioterapia. Każda z metod leczenia może być stosowana w monoterapii, jednak lepsze efekty osiąga się przy zastosowaniu terapii skojarzonej.

Refine search results

Ovarian cancer and inflammation. Part 2. Anti-inflammatory cytokines

Effect of regular physical activity on non-lipid (novel) cardiovascular risk factors

Ovarian cancer and inflammation. Part 1. Pro-inflammatory cytokines.

Benign endometrial lesions in premenopausal women: three-dimensional power Doppler sonography and cytokines content

Immunological determinants in a murine model of toluene diisocyanate-induced asthma

Inflammation mediators in employees in chronic exposure to neurotoxicants

Effects of work-related sleep restriction on acute physiological and psychological stress responses and their interactions: A review among emergency service personnel

Inflammatory response to acute exposure to welding fumes during the working day

Monoinfekcja Borrelia burgdorferi i współzakażenia Borrelia burgdorferi / Anaplasma phagocytophilum u pracowników leśnictwa i rolników

Keloidy – łagodne nowotwory tkanki łącznej powstające w wyniku zaburzeń gojenia