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Does benzo[a]pyrene affect the heart embryonic development?

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Kołodziejczyk Ł. M., Puzik M., Greń A., Batoryna M., Formicki G., Kapusta E.
Annales Universitatis Paedagogicae Cracoviensis Studia Naturae
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2018
EN
Benzo[a]pyrene is a polycyclic aromatic hydrocarbon of well proved toxic effect on animal cells and tissues. We used chicken in ovo developmental model to verify its influence on selected parameters of the heart rhythm and on the antioxidative defense in the heart tissue. We determined that the dose of 1 mg/kg weight of eggs of benzo[a]pyrene strongly activates the glutathione-dependent antioxidative system, but it do not significantly affect the heart conducting system of the chicken embryo. We postulate that further study on the benzo[a]pyrene action during embryonic development of birds is recommended.
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