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CREATIVITY AND PSYCHOPATHOLOGY IN THE LIGHT OF NOVEL NEUROBIOLOGICAL FINDINGS

100%
Kéri S.
Magyar Pszichologiai Szemle (Hungarian Psychological Review)
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2010
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vol. 65
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issue 2
243-272
EN
The stereotype of “mad genius” appears in our culture from time to time, having an influence on public thinking, biographies, arts, and sciences. The image of famous persons who simultaneously display eminent talent and achievement, suffering, oddness, and sometimes destructivity elicits fear, attraction, and admiration in common people. In the past decade, we witnessed a paradigm shift in the research of creativity and psychopathology; instead of the assessment of rare examples of eminent per-sons with labels of psychiatric diagnoses, schizotypal, affective, and autistic spectrum traits were evaluated in the general population in order to elucidate the relationship between common “psychopathology” and everyday creativity. Beyond the more and more sophisticated statistical characterization of the predictors of creative achievement, this new approach opens a door to the functional brain imaging and molecular genetic analysis of the complex phenotype of creativity.
2
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Gene-occupation interactions: a review of the literature on bladder and prostate cancer

86%
Wieczorek E., Wolniakowska A., Roszak J., Rodrigues R. M., Vanhaecke T., Reszka E.
Medycyna Pracy
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2023
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vol. 74
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issue 2
127-144
EN
Bladder cancer (BCa) and prostate cancer (PCa) are genitourinary cancers which constitute significant health problems in men and in which environmental factors play an important role. Understanding the genetic susceptibility to BCa or PCa and occupational exposure is paramount to improving cancer prevention and early detection. The aim of this review article was to address the scientific evidence on the genetic risk factors and occupational exposure associated with the occurrence of BCa and PCa. The authors identified relevant original articles that have been published between 1994 and 2023. Variations of the following search terms: “gene” and “occupational” combined with one of the following terms: “bladder cancer” or “prostate cancer” were applied for the search purpose. The authors found 342 publications of which 50 population studies met their requirements for gene-occupation interactions. In total, 34 full-text manuscripts were about BCa and 16 about PCa. These research examines the genes involved in detoxification processes of xenobiotics (glutathione S-transferase, N-acetyltransferase, cytochrome P450, UDP-glucuronosyltransferase), oxidative stress (glutathione peroxidase 1, manganese superoxide dismutase, catalase), altering DNA repair capacity (X-ray repair cross-complementing 1, base excision repair, nucleotide excision repair), tumour suppression (TP53 gene), and vitamin D pathway (vitamin D receptor gene). The role of genetic factors in the occupational exposure has not been conclusively established, but it appears the possibility of genetic involvement. Determination of environmentally responsive genes provides important mechanistic implications for the etiology of occupational cancers, and valuable input in occupational exposure limits set by taking genetic susceptibility into account. More genetic research is needed to corroborate these findings and assess their significance in the workplace. Med Pr. 2023;74(2):127–44
3
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Molekularne poskramianie lęków, czyli o płci konstruowanej genetycznie

86%
Derra A.
Przegląd Kulturoznawczy
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2013
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issue 1(15)
85–99
EN
The author considers the way contemporary genetics employs the notion of the gene. She studies its history and contemporary senses, being especially interested in how genetics defines sex. She presents the history of seeking for genetically defined masculinity pointing out how it has established oversimplified model of the phenomenon of biological sex. She underlines the role of feminist critiques in developing less narrow-minded views of sex in biology. The author shows that biology and especially genetics has promised to resolve doubts concerning human nature and the nature of sexes. Making this kind of promises can be interpreted as a special way of dealing with human fears which have appeared together with development of contemporary science and modern technologies and its impact on the world. It concerns especially fears of the interventions in natural environment and applications of the results of the research in genetics to medicine, both of which change the society and its values. When genetics has promised to find causal correlations between given genes and organisms’ properties, it was supposed to explain the source of diseases or even human personalities or specific social relations. Unequivocal explanations were needed to calm us down, to reduce fears, to allow us to state that this is how we are „by nature” made. As it turned out genetics was not able to fulfilled these promises for as the author is going to show, its objects of studies are more complex and complicated than the genetics have assumed.
4
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Granice niepodzielnego

72%
Kaczmarek A.
Kultura Współczesna. Teoria. Interpretacje. Praktyka
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2018
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vol. 102
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issue 3
200-207
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