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Comparison of two suicide attempts with long-acting insulin – The rare way to commit suicide

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Agnieszka Radzka A., Krystian Ciechański K., Jędrzej Tkaczyk J., Klaudia Brożyna K., Michał Tchórz M.
European Journal of Clinical and Experimental Medicine
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2018
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issue 2
151-154
EN
Introduction. In previous years, the number of suicide attempts has increased in Europe. Intoxication with hypoglycemic drugs, including insulin is a rare a tool for attempting suicide that may lead to a severe patient status. Aim. The aim of the study was to assess the severity of insulin poisoning with examples of two patients. Methods. The analysis of clinical history of patients and review of available literature. Results. A 22-year-old patient was hospitalized in the Department of Toxicology and Cardiology due to a suicide attempt in the way of insulin poisoning; time of poisoning was unknown, and the level of glucose was indeterminable. The patient was treated with intensive specific pharmacotherapy. After hospitalization, which lasted 5 months, the patient’s condition had been stabilized but with no verbal contact and quadriplegic paralysis. Another patient was a 41-year-old woman hospitalized two times in the Department of Toxicology and Cardiology due to the insulin poisonings. In each case of hospitalization of this woman, severe recurrent hypoglycemia was observed up to 25 mg% until the fifth day of hospitalization and the treatment used improved the patient’s condition and there was no development of serious complications. Conclusion. Normally effective treatment at the right time can recover the patient completely
2
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What next for diabetes mellitus?

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Witek B., Rochon-Szmejchel D., Kamińska D.
Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia
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2016
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issue Annales Universitatis Paedagogicae Cracoviensis Studia ad Didacticam Biologiae Pertinentia VI (2016)
6-19
3
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Efficacy of Lepidium Sativum to act as an anti-diabetic agent

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Mishra N., Mohammed A., Rizvi S.
Progress in Health Sciences
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2017
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vol. 7(1)
44-53
EN
Objective: Lepidium sativum, commonly known as chandrashoor in India, has been used in the Indian traditional medicine system for the treatment of various diseases. The present study was undertaken to investigate the hypoglycemic effect of Lepidium sativum in normal and streptozotocin-induced diabetic rats. Materials and methods: Thirty (30) adult male Wistar rats weighing 157±51g were randomly assigned to five groups of six rats each as Normal control, Diabetic control, Diabetics supplemented with Lepidium sativum extract, Diabetics treated with insulin, and Normal rats supplemented with Lepidium sativum. All rats were fed with a normal laboratory diet, nutrient rich pellets, and had free access to drinking water. The rats were injected with streptozotocin at a dose of 45 mg/kg body weight intraperitoneally to induce diabetes. The extracts were then given orally to different groups of rats at a dose of 20mg/kg body weight for 16 days. Thereafter, the rats were sacrificed, and blood samples collected by cardiac puncture were used for the determination of Glucose, Creatinine, Alkaline Phosphatase, Cholesterol, Malondialdehyde level, % DPPH, and FRAP content. Results: Administration of lepidium extract showed a significant reduction in glucose, creatinine, and alkaline phosphatase levels. Elevated cholesterol level was restored approximately to normal; a significant decrease in malondialdehyde levels was also observed compared to diabetic controls. Conclusion: Lepidium sativum extract shows efficacy in the prevention and management of diabetes mellitus and its related complications.
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Impact of special aviation gymnastics instruments training on selected hormones in cadets' blood serum and plasma

75%
Wochyński Z., Sobiech K.
International Journal of Occupational Medicine and Environmental Health
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2017
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vol. 30
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issue 4
655-664
EN
Objectives This study has aimed at investigating the impact of the Special Aviation Gymnastics Instruments (SAGI) training scheme on the blood serum cortisol, testosterone, insulin, and plasma adrenaline, noradrenaline, and dopamine in comparison with a control group. Material and Methods Fifty-five cadets, aged 20 years old, participated in the study. Cadets were divided into 2 groups: A (N = 41) – the SAGI-trained, and B (N = 14) – the control group. In both groups, blood was the examined material, sampled twice: before the training session (BT) and after the training session (AT), at the beginning (training session I), during (training session II), and after completion of the SAGI training session (training session III). Commercially available kits were used for assaying serum cortisol, testosterone, and insulin as well as plasma adrenaline, noradrenaline, and dopamine. Cadets’ physical fitness was assessed by means of Aero-Synthetic Efficiency Tests. Results In group A, a significant decrease in serum cortisol (training session III) and insulin in three training sessions AT in comparison with the values BT was seen. A statistically significant increase in testosterone and catecholamines was noted in all 3 training sessions AT in comparison with the values BT. In group B, a statistically significant increase in cortisol (training session II), testosterone, and catecholamines was observed in all 3 training sessions AT vs. the values in training session BT. In group B, serum levels of all assayed hormones were higher in training session III than those in group A. Conclusions In the examined group, the SAGI training produced fewer hormonal changes dependent on the intensity and exercise type and physical efficiency improvement than in the control group. Int J Occup Med Environ Health 2017;30(4):655–664
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