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Lipidomic profiles as a tool to search for new biomarkers

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Pisarska A., Wąsowicz W., Gromadzińska J.

International Journal of Occupational Medicine and Environmental Health

2022

vol. 35

issue 2

111-126

Lipidomics belongs to the family of the so-called omics domains, which, based on modern chemical technologies, strive to explain the biological principles of the organism’s functioning. Main biological functions of lipids include energy storage, the formation of cell membranes, and participation in the transmission of biological signals, and their dysregulation is responsible for the development of pathological states. Thanks to lipid profiling, potential biomarkers for disease diagnosis and prognosis can be identified. This paper discusses selected examples of the use of lipidomic tests in the diagnosis of the kidney, metabolic and neoplastic diseases based on research papers published over the last few years (since 2016). Only works based on the study of human biological material by mass spectrometry methods were taken into account. The examples of lipidomics application presented in this publication are only a few of the possibilities of this technique. As potential possibilities have already been discovered, the next step for the research community is to work on standardization of the approach to lipidomic research and to develop bioinformatics methods that allow efficient processing and analysis of large amounts of data generated in this technique.

Diagnostyka obrazowa kamicy nerkowej

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Śliwa M., Piątkowska N., Kajzar M., Saran A., Jarzumbek A., Bień K., Kluczewska E., Lewek P.

Gabinet Prywatny

2022

vol. 281

issue 02

36-42

Nephrolithiasis is common disease that affects 5-20% of the population in which insoluble deposits precipitate in the urinary tract. It usually affects young and professionally active people, which is why it is not only a medical problem, but also a social one. Among men, the peak incidence occurs at the age of 30–40 years, and among women at the age of 30–40 years and at the age of 50–65 years. The classic symptom of urolithiasis is a renal colic. However, the appearance of symptoms is often preceded by a long period of asymptomatic urolithiasis. You can diagnose urolithiasis on the basis of imaging tests. Performing ultrasound examinations allows you to detect deposits in the kidneys at the early stage of the disease development. The diagnostic imaging also includes an abdominal examination, computed tomography and urography. Treatment is based on removing existing stones as well as reducing risk factors. Conservative treatment involving the use of painkillers is applied. On the other hand, the urological procedures used include extracorporeal shock wave lithotripsy, flexible ureteroscopy, and percutaneous nephrolithotomy. The prognosis depends on etiological factors and is usually good. Early diagnosis and appropriate treatment improve the prognosis.

Kamica nerkowa jest częstym schorzeniem występującym u 5–20% populacji. W przebiegu tej choroby w drogach moczowych wytrącają się nierozpuszczalne złogi. Zwykle dotyczy to ludzi młodych i czynnych zawodowo, co stanowi problem nie tylko medyczny, ale także społeczny. U mężczyzn szczyt zachorowań przypada na 30.–40. r.ż., a u kobiet 30. –40. oraz 50.–65. r.ż. Typowym objawem kamicy jest kolka nerkowa. Pojawienie się objawów często poprzedza długi okres kamicy bezobjawowej. Kamicę można rozpoznać na podstawie badań obrazowych, takich jak: zdjęcie rentgenowskie przeglądowe, ultrasonografia, spiralna tomografia komputerowa, urografia. Wykonywanie badań ultrasonograficznych pozwala wykryć złogi w nerkach na wczesnym etapie rozwoju choroby. Leczenie polega na usuwaniu istniejących kamieni, jak i na ograniczaniu czynników ryzyka. Leczenie zachowawcze kamicy opiera się na stosowaniu leków przeciwbólowych oraz spazmolitycznych. Natomiast do stosowanych zabiegów urologicznych należą: pozaustrojowa litotrypsja falą uderzeniową, elastyczna ureteroskopia, przezskórna nefrolitotomia.

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1 Gabinet Prywatny

1 International Journal of Occupational Medicine and Environmental Health

1 Bień K.

1 Gromadzińska J.

1 Jarzumbek A.

1 Kajzar M.

1 Kluczewska E.

1 Lewek P.

1 Pisarska A.

1 Piątkowska N.

1 Saran A.

1 Wąsowicz W.

1 Śliwa M.

2 2022

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Lipidomic profiles as a tool to search for new biomarkers

Diagnostyka obrazowa kamicy nerkowej