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The reproductive parameters, lifestyle and health factors in relation to physiological menopausal symptoms in Slovak women

100%
Luptáková L., Siváková D., Michnová A., Čerňanová V., Cvíčelová M., Danková Z.
Anthropological Review
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2013
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vol. 76
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issue 2
217-228
EN
Menopause is associated with various physiological symptoms which can be related to the most common health problems in menopausal women and a decrease in their quality of life. Determinants of experiencing menopausal symptoms are complex because they include reproductive, environmental, lifestyle and social factors. The aim of this study is to assess whether selected reproductive, lifestyle and health factors are associated with the occurence of hot flushes, night sweats, palpitations, dizzy spells and/or pins and needles in the hands and feet. A total of 346 women aged between 39 and 59 years living in Slovakia were recruited for this cross-sectional survey. Data on menopausal symptoms and potential confounders were collected by questionnaire. Logistic regression analysis revealed an independent effect of peri-/postmenopausal status and depressed mood on the manifestation of hot flushes. Analysis results for night sweats were significant for age, depressed mood and current smoking at p<0.05 while, of all input parameters, only age and depressed mood were significant predictors of palpitations. Logistic regression also revealed the effect of sport and depressed mood on dizzy spells. Depressed women, (B=0.677) and those who did not participate in sporting activities (B= -0.969) suffered more often from dizzy spells. Pins and needles in hands and feet were influenced by peri-/postmenopausal status (B=1.036), by higher numbers of pregnancy (B=0.260) and depressed mood (B=0.505). Potentially modifiable factors, such as current smoking, lack of sport, depressed mood and the number of pregnancies can predispose a woman to a higher prevalence of some of these physiological menopausal symptoms.
2
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Markers of endothelial dysfunction in young non-overweight women - effect of serum lipids, body measures and nutrition

86%
Witkowska A., Zujko M.
Progress in Health Sciences
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2014
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vol. 4
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issue 1
24-30
XX
Purpose: Since endothelial dysfunction can develop early in the adulthood, the purpose of the study was to determine how serum lipids, body measures and dietary habits affect serum markers of vascular activation in young women. Materials and methods: Twenty five healthy women, aged 19-22 years, were enrolled in the study. Serum lipids profile (total cholesterol, HDL-cholesterol, triglycerides) was assayed with laboratory test kits. Concentrations of sICAM-1, sVCAM-1 and E-selectin were determined with the ELISA technique. Anthropometric measurements were taken including skinfold thickness and waist circumference. Food consumption data were collected using 3 repeats of 24-hour dietary recalls. Dietary habits of the women were assessed with a 9-point alternate Mediterranean Diet score (a-MED). Results: Sixty eight percent of the subjects had their HDL-cholesterol levels below the desirable concentration, 20% had LDL-cholesterol elevated, and 32% demonstrated increased total triacylglycerols (TAG). The levels of serum TAG >199 mg/dL were associated with a significant rise in the VCAM-1 concentration. Dietary wholegrain products seem to reduce the serum E-selectin. Conclusions: The results suggest that young women of normal body mass, but demonstrating increased levels of serum TAG, may be at risk of developing endothelial dysfunction. An implementation of the wholegrain products consumption into their dietary practices would possibly be of health benefit.
3
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Lipidomic profiles as a tool to search for new biomarkers

86%
Pisarska A., Wąsowicz W., Gromadzińska J.
International Journal of Occupational Medicine and Environmental Health
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2022
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vol. 35
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issue 2
111-126
EN
Lipidomics belongs to the family of the so-called omics domains, which, based on modern chemical technologies, strive to explain the biological principles of the organism’s functioning. Main biological functions of lipids include energy storage, the formation of cell membranes, and participation in the transmission of biological signals, and their dysregulation is responsible for the development of pathological states. Thanks to lipid profiling, potential biomarkers for disease diagnosis and prognosis can be identified. This paper discusses selected examples of the use of lipidomic tests in the diagnosis of the kidney, metabolic and neoplastic diseases based on research papers published over the last few years (since 2016). Only works based on the study of human biological material by mass spectrometry methods were taken into account. The examples of lipidomics application presented in this publication are only a few of the possibilities of this technique. As potential possibilities have already been discovered, the next step for the research community is to work on standardization of the approach to lipidomic research and to develop bioinformatics methods that allow efficient processing and analysis of large amounts of data generated in this technique.
4

Analiza pozostałości organicznych w ceramice kultury rzucewskiej z Rzucewa

72%
Cramp L. J. E., Król D., Rutter M., Heyd V., Pospieszny Ł.
Pomorania Antiqua
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2019
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vol. Tom XXVIII
s. 245-259
EN
During the lifetime of an unglazed pot, biomolecules from the vessel contents accumulate into pores in the vessel wall. Lipids, especially, survive over millennia and when extracted from archaeological pottery therefore yield diagnostic information regarding its original contents. Here we report the analysis of preserved lipids extracted from 15 Rzucewo culture pottery sherds, including bowls, vases and storage vessels, from Rzucewo, Puck Bay, Poland. This was undertaken in order to gain further insights into the subsistence economy and use of material culture by this Late Neolithic culture, who are thought to practice a mixed economy that incorporated domesticates into a subsistence base focused primarily upon seal-hunting. Lipids recovered from 13 of 15 sherds analysed could be characterised as of predominantly aquatic origin, with more limited evidence for some likely plant waxes from two vessels. The range of stable carbon isotope signatures of the fatty acids reflect a marine through to freshwater origin, which may have derived from animals fished or hunted from brackish waters, as well perhaps as the sea and inland rivers. There was no evidence for processing dairy products, in contrast with the published Rzucewo pottery from Nida, Lithuania (Heron et al. 2015), which may arise from the lack of beakers included in this vessel assemblage. These findings may also be contrasted with previously published studies from related Corded Ware and Globular Amphorae cultures (Cramp et al. 2014a; Heron et al. 2015; Roffet-Salque et al. 2017a; Robson et al. 2019) which reflect greater processing of terrestrial products, particularly ruminants, and including a strong dairying component (Cramp et al. 2014a; Roffet-Salque et al. 2017b). This preliminary study indicates the potential and necessity to investigate greater numbers of Rzucewo culture pottery from different vessel forms and a greater number of sites to gain more nuanced insights into the cultural and economic practices taking place.
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