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EN
The concentration of mercury (Hg) in fish species has direct consequences to health of man and ecosystem. Thus, in this paper, the accumulation of Hg in gills, liver, and muscle of the two fish species (Whipfin silver biddy – Gerres filamentosus and Flathead grey mullet – Mugil cephalus) were measured by cold vapor atomic absorption spectrometry. The fish specimens were collected from local markets and direct fishing with the help of fishermen over the period from July to September 2017 in coastal Vietnam. Differences in the total Hg were found both between two species and organs. The concentration of Hg in all organs investigated of Whipfin silver biddy was higher than of Flathead grey mullet (p < 0.05). The content of Hg in the muscles of Whipfin silver biddy was higher than in liver and gills (p < 0.05), 0.460, 0.245, 0.077 µg g-1 w.w., respectively. Liver of Flathead grey mullet had more Hg accumulated than muscle and gills (0.195, 0.097, 0.046 µg g-1 w.w., respectively). The results revealed that Hg concentrations in Flathead grey mullet did not exceed food fish safety limits established for human consumption while concentration of this toxic element in muscles of Whipin silver biddy almost reached the maximum permissible level.
EN
Objectives: The aim of this work is to perform comparative estimation of cytokines levels in chlorinated hydrocarbons and metallic mercury exposure in employees in the dynamics of neurologic disorders formation. Material and Methods: The contents of cytokines IL-1β, IL-2, IL-4, IL-6, TNF-α, INF-γ were determined in blood sera using the method of hardphasic immunoferment analysis. The significance of different average values was assessed using the parametric and non-parametric criteria - Student (in normal distribution) and Mann-Whitney tests taking into account the Bonferonni correction (non-difference from normal distribution). Results: It was shown that, a number of inflammation mediators with the dominance, depending on the expositional toxicant and expression of neurological deficiency, take part in the neurointoxication development. Healthy employees show pro-inflammatory responses with different expression degree, which dominate in the immune regulation processes regardless of the expositional factors (metallic mercury vapors and chlorinated hydrocarbons). Conclusions: The production intensity and interconnection between the pro- and anti-inflammatory cytokines may change in the occupational injuries of the nervous system development process. The decrease in the serum concentrations of cytokines along with the increase of clinical manifestation severity may prove dysregulation of the immune system, which promotes maintaining of pathological process and progradient process of neurointoxication. The most obvious is the imbalance of cytokines in the employees exposed to metallic mercury (in all the examined groups) that increases neurointoxication in the distant period.
EN
Objectives: The aim of the study was to make an international comparison of blood levels of cadmium (B-Cd), lead (BPb) and mercury (B-Hg) of women in seven European, and three non-European cities, and to identify determinants. Materials and Methods: About 50 women (age: 46–62) from each city were recruited (totally 480) in 2006–2009. Interview and questionnaire data were obtained. Blood samples were analysed in one laboratory to avoid interlaboratory variation. Results: Between the European cities, the B-Pb and B-Cd results vary little (range of geometric means: 13.5–27.0 μg/l and 0.25–0.65 μg/l, respectively); the variation of B-Hg was larger (0.40–1.38 μg/l). Between the non-European cities the results for B-Pb, B-Cd and B-Hg were 19.2–68.0, 0.39–0.99 and 1.01–2.73 μg/l, respectively. Smoking was a statistically signifi cant determinant for B-Cd, while fi sh and shellfi sh intakes contributed to B-Hg and B-Pb, amalgam fi llings also contributed to B-Hg. Conclusions: The present results confi rm the previous results from children; the exposure to lead and cadmium varies only little between different European cities suggesting that other factors than the living area are more important. The study also confi rms the previous fi ndings of higher cadmium and lead levels in some non-European cities. The geographical variation for mercury is signifi cant.
EN
Objectives Gold miners use mercury to extract gold from ore adding liquid mercury to the milled gold-containing ore. This results in a mercury-gold compound, called amalgam. Miners smelt this amalgam to obtain gold, vaporizing it and finally inhaling the toxic mercury fumes. The objective was to merge and analyze data from different projects, to identify typical signs and symptoms of chronic inorganic mercury exposure. Material and Methods Miners and community members from various artisanal small-scale gold mining areas had been examined (Philippines, Mongolia, Tanzania, Zimbabwe, Indonesia). Data of several health assessments were pooled. Urine, blood and hair samples were analyzed for mercury (N = 1252). Questionnaires, standardized medical examinations and neuropsychological tests were used. Participants were grouped into: Controls (N = 209), living in an exposed area (N = 408), working with mercury as panners (N = 181), working with mercury as amalgam burners (N = 454). Chi2 test, linear trend test, Mann-Whitney test, Kruskal-Wallis test, correlation coefficient, Spearman’s rho, and analysis of variance tests were used. An algorithm was used to define participants with chronic mercury intoxication. Results Mean mercury concentrations in all exposed subgroups were elevated and above threshold limits, with amalgam burners showing highest levels. Typical symptoms of chronic metallic mercury intoxication were tremor, ataxia, coordination problems, excessive salivation and metallic taste. Participants from the exposed groups showed poorer results in different neuropsychological tests in comparison to the control group. Fifty-four percent of the high-exposed group (amalgam burners) were diagnosed as being mercury-intoxicated, compared to 0% within the control group (Chi2 p < 0.001). Conclusions Chronic mercury intoxication, with tremor, ataxia and other neurological symptoms together with a raised body burden of mercury was clinically diagnosed in exposed people in artisanal small-scale mining areas. The mercury exposure needs to be urgently reduced. Health care systems need to be prepared for this emerging problem of chronic mercury intoxication among exposed people. Int J Occup Med Environ Health 2017;30(2):249–269
EN
Fatty acids derived from fish and fish oils have a strong beneficial effect on cardiovascular health and neurodevelopment. Dietary omega 3 fatty acids prevent cardiovascular disease development by the influence on eicosanoid synthesis, cytokine and growth factors production, lipid and lipoprotein metabolism, endothelial relaxation. They have a strong antiarrhytmic action on the heart. Enhanced consumption of fish derived fatty acids is related to the low incidence of cardiovascular events and sudden cardiac deaths. High content of mercury in some fishes may attenuate the beneficial effects of omega 3 fatty acids on cardiovascular health and also on neurodevelopment of newborns and children
PL
Przeszło 30 lat temu zaobserwowano, iż Eskimosi, których dieta opiera się na tłustych rybach morskich, rzadko chorują na choroby układu krążenia takie jak choroba niedokrwienna serca, zawał mięśnia sercowego. Obserwacje te dały początek licznym badaniom epidemiologicznym, klinicznym i doświadczalnym mającym na celu wyjaśnienie tego zjawiska. Obecnie nie ulega wątpliwości, iż ryby będące źródłem niezbędnych nienasyconych kwasów tłuszczowych z grupy n-3 (n-3 PUFA) są ważnym składnikiem pożywienia, gdyż zawarte w nich kwasy tłuszczowe istotnie wpływają na szereg przemian metabolicznych i tym samym na ryzyko rozwoju różnych chorób.
EN
Mercury was commonly used to treat syphilis in post-medieval Europe, but debate persists about whether it ameliorated infection or exacerbated it. As there are no in vitro studies on mercury’s effectiveness, Hg levels were characterized using an established technique, portable X-Ray Florescence Spectrometry (pXRF) in syphilitic skeletons (N=22) from six post-medieval London cemeteries. Levels were assessed against proxies for syphilitic infection severity (lesion type, episodic involvement, extent of involvement), oral health indicators, and age at death. The findings are equivocal, likely obfuscated by background poor oral health and high mortality, and cannot elucidate whether mercury ‘killed or cured’.
EN
Objectives The authors aimed to evaluate whether blood cadmium (B-Cd), lead (B-Pb) and mercury (B-Hg) in children differ regionally in 9 countries, and to identify factors correlating with exposure. Material and Methods The authors performed a cross-sectional study of children aged 7–14 years, living in 2007–2008 in urban, rural, or potentially polluted (“hot spot”) areas (ca. 50 children from each area, in total 1363 children) in 6 European and 3 non-European countries. The authors analysed Cd, Pb, and total Hg in blood and collected information on potential determinants of exposure through questionnaires. Regional differences in exposure levels were assessed within each country. Results Children living near industrial “hot-spots” had B-Cd 1.6 (95% CI: 1.4–1.9) times higher in the Czech Republic and 2.1 (95% CI:1.6–2.8) times higher in Poland, as compared to urban children in the same countries (geometric means [GM]: 0.13 μg/l and 0.15 μg/l, respectively). Correspondingly, B-Pb in the “hot spot” areas was 1.8 (95% CI: 1.6–2.1) times higher than in urban areas in Slovakia and 2.3 (95% CI: 1.9–2.7) times higher in Poland (urban GM: 19.4 μg/l and 16.3 μg/l, respectively). In China and Morocco, rural children had significantly lower B-Pb than urban ones (urban GM: 64 μg/l and 71 μg/l, respectively), suggesting urban exposure from leaded petrol, water pipes and/or coal-burning. Hg “hot spot” areas in China had B-Hg 3.1 (95% CI: 2.7–3.5) times higher, and Ecuador 1.5 (95% CI: 1.2–1.9) times higher, as compared to urban areas (urban GM: 2.45 μg/l and 3.23 μg/l, respectively). Besides industrial exposure, traffic correlated with B-Cd; male sex, environmental tobacco smoke, and offal consumption with B-Pb; and fish consumption and amalgam fillings with B-Hg. However, these correlations could only marginally explain regional differences. Conclusions These mainly European results indicate that some children experience about doubled exposures to toxic elements just because of where they live. These exposures are unsafe, identifiable, and preventable and therefore call for preventive actions.
EN
Diverse forms of mercury (Hg) have various effects on animals and humans because of a variety of routes of administration. Inorganic mercury (iHg) binds to thiol groups of proteins and enzymes in one’s body or is methylated by microorganisms. Organic form of Hg, contrary to the iHg, is more stable but may be demethylated to Hg2+ in the tissue of intestinal flora. Selenium (Se) also occurs in a variety of chemical forms in one’s body but both of these elements behave very differently from one another. Mercury binding to selenide or Se-containing ligands is a primary molecular mechanism that reduces toxicity of Hg. Complexes formed in such a way are irreversible, and thus, biologically inactive. Se deficiency in a human body may impair normal synthesis of selenoproteins and its expression because expression of mRNA may be potentially regulated by the Se status. This paper provides a comprehensive review concerning Hg–Se reciprocal action as a potential mechanism of protective action of Se against Hg toxicity as well as a potential detoxification mechanism. Although interactions between Hg–Se have been presented in numerous studies concerning animals and humans, we have focused mainly on animal models so as to understand molecular mechanisms responsible for antagonism better. The review also investigates what conclusions have been drawn by researchers with respect to the chemical species of Se and Hg (and their relationship) in biological systems as well as genetic variations and expression and/or activity of selenoproteins related to the thioredoxin (thioredoxin Trx/TrxR) system and glutathione metabolism. Int J Occup Med Environ Health 2018;31(5):575–592
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