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EN
Objectives: This study aims to assess the frequency and factors relevant to metabolic syndrome in workers employed in the collection and disposal of solid waste sector. Materials and Methods: This cross-sectional study was conducted in the major solid waste collecting and disposal company named İSTAÇ AŞ (İstanbul Environmental Protection and Waste Processing Corporation) in Istanbul, Turkey. All 715 male employees of the company were included in the study without sampling. The study was completed with 619 subjects. Since it was a small group, female workers were not taken into account in the study. Metabolic syndrome frequency was investigated according to the NCEP-ATP III criteria including the levels of systolic and diastolic blood pressure, waist perimeter, HDL, triglyceride, fasting blood glucose values. Results: Metabolic syndrome was present in 40.9% of participating employees. Metabolic syndrome was more common in those working in the excavation field (54.0%), such as caterpillar operators (56.5%), and less common in employees working in administrative offices, such as office staff or managers, who were under 35 years old and who had been working for less than 10 years (p < 0.05). Employees working in work stations other than administrative offices had a 2.60 times higher risk compared to those working in administrative offices. Conclusions: Metabolic syndrome may be related to work station, job, age and period worked by the subjects.
EN
Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.
PL
Praca ta ma na celu przybliżyć historię badań i leczenia otyłości. Ten problem zdrowotny zajmuje istotne miejsce w historii medycyny już od czasów Hipokratesa. Mimo ogromnego postępu medycyny, zasadnicze leczenie otyłości do dziś opiera się na diecie i aktywności fizycznej. Niestety te proste zasady, w zderzeniu z zasadniczymi zmianami stylu życia, jakie zaszły w populacji ludzkiej w XX wieku, zdają się być coraz mniej przestrzegane. Efektem tego jest obserwowana współcześnie epidemia otyłości, w walce z którą zdajemy się wciąż przegrywać.
EN
The aim of the study was a presentation of history of research studies and treatment of obesity. This health problem take an important place in history of medicine since the times of Hippocrates. Despite great progress of medicine, the basic rules of obesity treatment rest on the diet and physical activity. Unfortunately these two simple rules, in collision with fundamental changes in lifestyle, which took place in human population in XX century, seem to be less complied with overtime. The effect of it seems to be the recently observed epidemic of obesity. The fight with this epidemic we are still loosing.
EN
Objectives This study’s objective was to examine association between sleep duration and sleep quality, and metabolic syndrome (MetS) and its components in Taiwanese male police officers. Material and Methods Male police officers who underwent annual health examinations were invited to join the study and eventually a total of 796 subjects was included in it. The study subjects were divided into 5 groups according to the length (duration) of sleep: < 5, 5–5.9, 6–6.9, 7–7.9 and ≥ 8 h per day, and the global Pittsburgh Sleep Quality Index was used to categorize their sleep quality as good or poor. To analyze the association between sleep problems and MetS, adjusted odds ratio and respective 95% confidence intervals (CI) were computed. Results The prevalence of MetS in Taiwanese male police officers was 24.5%. Abdominal obesity had the highest proportion (36.2%) among 5 components of MetS. More than 1/2 of the police officers (52.3%) had poor sleep quality. Police officers with higher scores of sleep disturbances had a higher prevalence of MetS (p = 0.029) and abdominal obesity (p = 0.009). After adjusting for age, low-density lipoprotein cholesterol, smoking status, alcohol drinking habit, physical habitual exercise, snoring and type of shift work, the police officers who slept less than 5 h were 88% more likely to suffer from abdominal obesity than those who slept 7–7.9 h (95% CI: 1.01–3.5). Sleep quality was not associated with MetS and its components. Conclusions The police officers who slept less than 5 h were more likely to experience abdominal obesity in Taiwan, and those with higher scores of sleep disturbances had a higher prevalence of MetS and abdominal obesity. It is recommended that police officers with short sleep duration or sleep disturbances be screened for MetS and waist circumference in order to prevent cardiovascular diseases.
EN
Objectives To establish a practical method for assessing the general metabolic health conditions among different employee groups, this study utilized the total count of metabolic syndrome (MetS) elements as a parameter, and performed a retrospective analysis comparing changes of MetS component count (MSC) of 5 years among day-time work (DW) and day-andnight rotating shift work (RSW) employees. Material and Methods The data of personal histories, physical examinations, blood tests, abdominal sonographic examinations and occupational records were collected from a cohort of workers in an electronics manufacturing company. We first defined the arithmetic mean value of MSC as MSC density (MSCD) for the employee group; then we compared the changes of MSCD over 5 years between DW and RSW workers. Occupational, personal and health records were analyzed for the 1077 workers with an initial mean age of 32.4 years (standard deviation (SD): 6.2 years), including 565 RSW workers (52%). Results The initial MSCDs were 1.26 and 1.12 (p = 0.06) for DW and RSW workers, respectively; after 5 years, the increments of MSCD for DW and RSW workers were 0.10 and 0.39, respectively (p < 0.01). By performing multivariate logistic regression analyses, and comparing with DW co-workers, final results indicated that the workers exposed to RSW have 1.7-fold increased risk of elevated MSCD (95% confidence interval (CI): 1.28–2.25, p < 0.01); and are 38% less likely (adjusted rate ratio (aRR) 0.62, 95% CI: 0.45–0.86, p < 0.01) to attain decreased MSCD. Conclusions These observations demonstrate that changes of MSCD are significantly different between DW and RSW workers, and are increasingly associated with RSW exposure. In conclusion, MSCD can represent the general metabolic health conditions of a given employee group; MSC, MSCD and their transitional changes can be applied as simple and standardized tools for monitoring metabolic health risk profiles when managing employee health, at both the individual and company levels.
EN
Objectives The aim of the study was to assess health status of regular and part-time mines rescue brigadesmen. Material and Methods A group of 685 mines rescue brigadesmen was examined within the preventive testing – a basic internal, biochemistry and anthropometric examination, physical fitness testing. Results The average age of the subjects was 41.96±7.18 years, the average exposure in mining was 20±8.1 years, out of that 11.95±7.85 years as mines rescue brigadesmen. Elevated levels of total serum cholesterol (T-CH) and low-density lipoprotein cholesterol (LDL-CH) were found in over 1/2 of the subjects. Systolic hypertension (systolic blood pressure (SBP) ≥ 140 mm Hg) was confirmed in 34%, overweight (body mass index (BMI) ≥ 25) in 62.3% and obesity (BMI ≥ 30) in 20.4% of the examined mines rescue brigadesmen. The metabolic syndrome was found in 15.2% of persons. The highest physical fitness was found in mines rescue brigadesmen and the lowest in mine officers. Limit values of maximum oxygen uptake ($\text{VO}_\text{2 max}$/kg) determined by the management of the mine rescue station were not reached by every 3rd of all mines rescue brigadesmen. Compared with the control group of the Czech and Slovak population, the rescuers are taller, have greater BMI, higher percentage of body fat in all age categories and proportionally to that they achieve a higher maximum minute oxygen uptake; however, in relative values per kg of body weight their physical fitness is practically the same as that of the controls. Conclusions The prevalence of risk factors of cardiovascular diseases and $\text{VO}_\text{2 max}$/kg in the group of the mines rescue brigadesmen is comparable with that in the general untrained Czech population.
EN
The term metabolic syndrome (MetS) defines the cooccurrence of the related risk factors of metabolic origin that promote the development of cardiovascular diseases with atherosclerotic background and type 2 diabetes. The diagnostic criteria of MetS have undergone modifications for years. Until now no clear definition of MetS has been established. The latest diagnostic criteria of MetS published in 2009 by a group of IDF (International Diabetes Federation) and AHA/NHLBI (American Heart Association/ National Heart, Lung and Blood Institute) experts discern three out of five risk factors: abdominal obesity (taking into consideration population differences), elevated level of triglycerides, reduced HDL cholesterol, hypertension and fasting hyperglycemia. Genetic predispositions and environmental factors, such as lack of physical activity and improper diet are considered to be responsible for MetS development. Therefore, prevention and treatment of MetS should be based first of all on a change in modifiable lifestyle factors, among which proper diet is of essential importance.
EN
Objectives: Sense of coherence (SOC) is an individual characteristic related to a positive life orientation, leading to effective coping. Little is known about the relationship between SOC and metabolic syndrome (MetS). This cross-sectional study aimed at testing the hypothesis that workers with a strong SOC have fewer atherosclerotic risk factors, including MetS, and healthier lifestyle behaviors. Material and Methods: One hundred and sixty-seven computer software workers aged 20–64 years underwent a periodical health examination including assessment of body mass index, waist circumference, blood pressure, blood lipid levels, fasting blood sugar (FBS) levels and lifestyle behaviors (walking duration, smoking status, nutrition, alcohol consumption, and sleep duration). During this period, the participants also completed a 29-item questionnaire of SOC and the Brief Job Stress Questionnaire to assess job stressors such as job strain and workplace social support. Results: Our results showed that the participants with a stronger SOC were likely to walk for at least 1 h a day, to eat slowly or at a moderate speed, and to sleep for at least 6 h. Compared with the participants with the weakest SOC, those with the strongest SOC had a significantly lower odds ratio (OR) for being overweight (OR = 0.31; 95% confidence interval (CI): 0.11–0.81), and having higher FBS levels (OR = 0.11; 95% CI: 0.02–0.54), dyslipidemia (OR = 0.29; 95% CI: 0.09–0.84), and MetS (OR = 0.12; 95% CI: 0.02–0.63), even after adjusting for age, gender and job stressors. Conclusions: High SOC is associated with a healthy lifestyle and fewer atherosclerotic risk factors, including MetS.
EN
Objectives: This study examined the effect of shift work on developing the metabolic syndrome by comparing groups of exposed and unexposed Iranian drivers. Methods: We considered as night-shift drivers those drivers whose shifts included at least 15 h per week between 9:00 p.m. and 7:00 a.m. Daytime drivers were defi ned as drivers working regularly without shift work. 3039 shift work drivers were selected. These were matched with non-shift workers. The differences in baseline characteristics and the prevalence of the components of the metabolic syndrome were assessed with Student's t test, and chi-square tests. Results: We found central adiposity in 52.0% of the shift workers versus 42.6% of the day workers (p < 0.0001). The hypertension component was not signifi cantly related to shift work (p > 0.05); but there were signifi cant differences as regards other components of the metabolic syndrome (p < 0.0001). Among the shift workers, the odds ratios of the increased FBS, low HDL-C, higher TG levels, as well as higher waist circumference were 1.992 (95% CI: 1.697-2.337), 1.973 (95% CI: 1.759-2.213), 1.692 (95% CI: 1.527-1.874), and 1.460 (95% CI: 1.320-1.616), respectively. The metabolic syndrome was more common among the shift workers (OR = 1.495; 95% CI: 1.349-1.657). Conclusion: In evaluating such results, further consideration is needed to fi nd pathophysiological clarifi cation; in turn, stress linked to shift work must be considered to likely have had a relevant infl uence on the outcome. In our opinion, shift work acts as an occupational factor for the metabolic syndrome.
EN
Measurement of body weight, height, waist and hip circumference is a standard procedure that allows to better define the risk of metabolic syndrome. The aim of the study is to determine the usefulness of anthropometric indicators such as BMI, WC (waist circumference), WHR, WHtR and percentage of body fat to predict the metabolic cardiovascular risk in the adult male population of Krakow, as well as an attempt to determine the metabolic cardiovascular risk with the original anthropometric risk index. The study included 405 men from the population working in the T. Sendzimir Steelworks in Kraków at the age of 30-69 years. Anthropometric measurements: body height measured to the nearest mm, circuits (waist, hips) measured to the nearest centimetre, the percentage of fat (the type of electronic scales Tanita BF 300) measured according to the standard protocol by the same technician and biomedical indicators assessing the functional status of organism, total cholesterol, HDL, LDL, triglycerides, glucose and blood pressure measured with a mercury manometer. As a measure of goodness of fit for the indices of risk (and their components), the AUC method was used for the ROC curves to evaluate the sensitivity and specificity of the diagnostic test. The results show that significant in predicting the risk of metabolic syndrome are not only standard anthropometric measurements specified in the standards of WHO, EGIR, NCEP and IDF. In addition, it is important to take into account the amount of fat and calculate the cumulative risk index based on all relevant measurements and indicators.
EN
Objectives: Both hyperthyroidism and overt hypothyroidism are associated with increased prevalence of metabolic syndrome and its components, while data on subclinical hypothyroidism is currently limited especially in working populations. The aim of this study was to examine the association between subclinical hypothyroidism and metabolic syndrome components in workers; and to evaluate whether there are differences by sex and occupation. Material and Methods: A total of 1150 university employees (male - 792, female - 358) aged 30-60 years who came for an annual medical check-up were studied. Anthropometric measurements were taken, and blood pressure, fasting plasma glucose (FPG), lipid profiles, thyroid stimulating hormone (TSH), free thyroxin (FT4) and free triiodothyronine (FT3) levels were measured. Results: After adjustment for age and body mass index (BMI), TSH was positively associated with increased triglyceride (TG) levels (β = 0.108, p = 0.020) and FPG (β = 0.130, p = 0.006) in subclinical hypothyroid male workers. However, TSH was not associated (p > 0.05) with any component of metabolic syndrome (MS) in the euthyroid group. In females, TSH was not correlated with MS components in both euthyroid and subclinical hypothyroid groups. Furthermore, comparison by occupation showed higher TSH in subclinical hypothyroid male workers employed in administration (5.23±0.52 mU/l) than those working as academics (5.12±0.52 mU/l), which resulted in elevated systolic and diastolic blood pressure, FPG, total cholesterol, TG and high density lipoprotein cholesterol. In females, BMI, systolic and diastolic blood pressure, TG and FPG were significantly (p < 0.05) higher in subclinical hypothyroid administrators than those in academics. Conclusions: Subclinical hypothyroidism was associated with metabolic syndrome components in male workers and not in females. Administration workers showed increased metabolic risks compared to academics. The findings suggest that the assessment of thyroid function in individuals with metabolic syndrome in the workplace may be favorable especially among men.
EN
Objectives The term metabolic syndrome (MetS) refers to the coexistence of interlinked risk factors of metabolic origin, contributing to the development of arteriosclerotic cardiovascular diseases as well as type 2 diabetes and their cardiovascular complications. The aim of the study is the assessment of the prevalence of MetS among paramedics of the Świętokrzyskie Center of Emergency Medical Services, depending on the adopted diagnostic criteria. Material and Methods The study included 140 paramedics (2 women and 138 men), aged 23–60 years old (median = 43 years, average age = 41.5 years, standard deviation = 10.8 years). The age distribution of the subjects was significantly different from the normal distribution (p-value < 0.0001). The oldest age group (50 years old and above) was overrepresented by nearly a half compared to the youngest group (up to 29 years old). Metabolic syndrome was defined on the basis of the International Diabetes Federation (IDF) criteria from 2005 and IDF in agreement with the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) from 2009. Results According to the IDF/2005 criteria, in which the necessary condition is the diagnosis of central obesity, MetS was recorded in 26.4% of the subjects (37 people). This is statistically significantly less often than the IDF/AHA/NHLBI/2009 definition of p = 0.001 – 35%. The frequency of the MetS occurrence was statistically significantly related to the age of the subjects and the age groups. Conclusions The prevalence of the MetS in the subject group is evaluated to be significant. The prevalence of MetS is diversified by the applied diagnostic criteria with age being the factor increasing its frequency. The most common factor influencing the prevalence of MetS is blood pressure and waist circumference. Int J Occup Med Environ Health 2018;31(6):741–751
EN
Objectives: To elucidate the association between metabolic syndrome (MetS) and disability due to low back pain (LBP) among care workers. Material and Methods: This cross-sectional study enrolled 656 care workers having experienced LBP in the year prior to the year of this study. The Roland-Morris Disability questionnaire (RDQ) and self-reported questionnaires regarding LBP, fear of movement, depressive symptom, psychosocial factors, intensity of pain, and duration of pain were administered, and a medical examination was performed. Metabolic syndrome was defined according to the international definition agreed in 2009. Out of the 656 care workers, we included 316 care workers (response rate: 48.2%) who had fully completed the questionnaires as the study sample (males: 13.6%, median age = 51 years old, range: 35–74 years old). To examine the association between MetS and the level of disability due to LBP, we used the Poisson regression analysis and estimated crude and adjusted prevalence ratios (PR). Results: Out of the 316 care workers, 52 (16.5%) were diagnosed as having MetS. Metabolic syndrome was significantly associated with the RDQ score (adjusted PR: 1.57, 95% confidence interval (CI): 1.17–2.11) after adjusting for covariates, such as age, sex, fear of movement, job demands, social support, intensity of pain, and duration of pain. Conclusions: This study showed that MetS was independently associated with disability due to LBP among care workers. A multidisciplinary intervention taking MetS into consideration may be an effective way to reduce disability due to LBP in people with both LBP and MetS. Int J Occup Med Environ Health 2018;31(2):165–172
EN
Background: Vitamins A, C and E are important parts of the antioxidant barrier. Polish data on antioxidant vitamins deficiency in the population are rare, especially among physically active people with metabolic disorders. The aim of this study was to evaluate the serum concentrations of vitamins A, C and E in people with metabolic syndrome (MS) working in agriculture, the prevalence of their deficiency in these workers, and the correlation between antioxidant vitamins concentration and traditional biomarkers of cardiovascular diseases. Material and Methods: The study included 332 residents of the Łódź Voivodeship working in agriculture: 231 people with MS and 101 healthy ones. The serum concentrations of vitamins A, C and E were assessed using the chemiluminescent immunoassay technology. The antioxidant vitamins intake was assessed by means of a 24-h recall questionnaire using Diet 5.0 software. Results: The mean serum concentrations of vitamins A, C and E were significantly lower in the MS workers than in the healthy ones No correlation was found between the antioxidant vitamins concentration and the dietary intake but there was a correlation between the antioxidant vitamins concentration and high-density lipoprotein cholesterol (HDL-C). A correlation was found between the serum concentrations of vitamins A and C, and vitamins A and E, in the MS workers. Conclusions: The serum concentrations of antioxidant vitamins in the MS workers were significantly lower than in the healthy controls, despite the similar physical activity level. The dietary intake had no impact on the serum concentrations of these vitamins. The HDL-C concentration in the MS workers correlated with the concentrations of all antioxidant vitamins.
PL
Wstęp: Witaminy A, C i E stanowią ważną barierę antyoksydacyjną. Danych dotyczących stanu odżywienia populacji polskiej witaminami antyoksydacyjnymi jest niewiele, a szczególnie mało dotyczy osób aktywnych fizycznie z zaburzeniami metabolicznymi. Celem badania była ocena stężenia witamin A, C i E w surowicy krwi i częstości ich niedoborów u osób z zespołem metabolicznym (ZM) pracujących w rolnictwie oraz zależności między stężeniem witamin antyoksydacyjnych w surowicy a tradycyjnymi biomarkerami chorób sercowo-naczyniowych. Materiał i metody: W badaniu wzięło udział 332 mieszkańców województwa łódzkiego pracujących w rolnictwie: 231 osób z ZM i 101 osób zdrowych. Stężenie witamin A, C i E w surowicy krwi badano za pomocą wysokosprawnej chromatografii cieczowej, a spożycie witamin z dietą oceniano za pomocą programu Dieta 5.0 na podstawie 24-godzinnych wywiadów żywieniowych. Wyniki: Średnie stężenia witamin A, C i E w surowicy krwi osób z ZM były istotnie mniejsze niż w grupie bez ZM. Stężenie nie korelowało ze spożyciem witamin z dietą, ale korelowało ze stężeniem cholesterolu HDL. Stwierdzono korelację między stężeniem w surowicy witamin A i C oraz A i E u pracowników z ZM. Wnioski: Stężenie witamin antyoksydacyjnych w surowicy pracowników z ZM było istotnie mniejsze niż w grupie osób zdrowych, mimo podobnego poziomu aktywności fizycznej. Wysokie spożycie witamin z dietą nie różnicowało ich stężenia w surowicy osób z ZM zatrudnionych w rolnictwie. Stężenie cholesterolu HDL u osób z ZM korelowało ze stężeniem wszystkich witamin antyoksydacyjnych.
EN
Background: Polish data on vitamin D deficiency in the population are incomplete. Vitamin D deficiency seems to be common, but there is a lack of studies concerning the concentration of 25(OH)D in people with high UV exposure. The aim of this study was to evaluate the plasma concentration of 25(OH)D in people with and without metabolic syndrome (MS), working in agriculture, the prevalence of its deficiency in these workers, and the correlation between the plasma concentration of 25(OH)D and traditional biomarkers of cardiovascular diseases. Material and Methods: The study included 332 people working in agriculture in the Łódź voivodeship, including 231 people with MS and 101 healthy ones. The plasma concentration of 25(OH)D was assessed using the chemiluminescent immunoassay technology. The vitamin D intake was assessed using a 24-h recall questionnaire using Diet 5.0 software. Results: The mean plasma concentration of 25(OH)D was 13.64±8.01 ng/ml in MS workers, and it was significantly lower than in the healthy ones (26.61±10.12 ng/ml, p < 0.00001); the highest concentration of 25(OH)D was noted in summer months. Deficient plasma concentrations of 25(OH)D were found significantly more often in MS workers than in the controls (81.82% and 20.79%, respectively, p < 0.00001). No correlation was found between the plasma vitamin D concentration and its dietary intake. The plasma concentration of 25(OH)D correlated with age of the examined workers (r = –0.28, p = 0.023), high density lipoprotein concentration (r = 0.19, p = 0.036) and glucose concentration (Rho = –0.24, p = 0.02). A multivariate analysis of variance demonstrated that the body mass index affected significantly the mean value of the 25(OH)D concentration in MS workers. Conclusions: The concentration of vitamin D in the plasma of workers with MS was significantly lower than in the healthy controls despite the same high UV exposure; these workers also manifested significantly higher 25(OH)D deficiency than the control subjects. This study indicates the need for further research on the concentration of 25(OH)D in people with metabolic disorders regardless of UV exposure and vitamin D intake with a diet.
PL
Wstęp: Dane dotyczące stanu odżywienia witaminą D populacji polskiej są niepełne. Niedobory witaminy D wydają się powszechne, jednak nie odnaleziono polskich badań, które weryfikowałyby stężenie 25-hydroksywitaminy D [25(OH)D] u osób intensywnie eksponowanych na promieniowanie ultrafioletowe (UV). Celem pracy była ocena stężenia 25(OH)D w osoczu osób z zespołem metabolicznym (ZM) pracujących w rolnictwie, częstość jej niedoborów u tych osób oraz zależność między stężeniem 25(OH)D w osoczu a tradycyjnymi biomarkerami chorób sercowo-naczyniowych. Materiał i metody: W badaniu wzięło udział 332 mieszkańców województwa łódzkiego pracujących w rolnictwie, w tym 231 osób z ZM i 101 zdrowych. Stężenie 25(OH)D w osoczu oceniano z użyciem testu wykorzystującego technologię chemiluminescencyjnych testów immunologicznych. Spożycie witaminy D z dietą oceniano za pomocą programu Dieta 5.0 na podstawie 24-godzinnych wywiadów żywieniowych. Wyniki: Średnie stężenie 25(OH)D w osoczu pracowników z ZM wynosiło 13,64±8,01 ng/ml i było istotnie niższe niż w grupie badanych bez ZM (26,61±10,12 ng/ml, p < 0,00001). Najwyższe średnie stężenie 25(OH)D odnotowano w miesiącach letnich. U pracowników z ZM istotnie częściej niż w grupie bez ZM stwierdzono deficytowe stężenie 25(OH)D w osoczu (odpowiednio, 81,82% i 20,79%, p < 0,00001). Stwierdzono brak korelacji między stężeniem 25(OH)D a jej spożyciem z dietą. Stężenie 25(OH)D korelowało z wiekiem (r = –0,28, p = 0,023) oraz stężeniami cholesterolu HDL (r = 0,19, p = 0,036) i glukozy (Rho = –0,24, p = 0,02) w badanej grupie rolników. Wieloczynnikowa analiza wariancji wykazała, że u pracowników z ZM czynnikiem wpływającym istotnie na średnią wartość stężenia 25(OH)D był wskaźnik masy ciała. Wnioski: Stężenie witaminy D w osoczu osób z ZM było istotnie mniejsze niż u osób zdrowych mimo jednakowej, wysokiej ekspozycji na promieniowanie UV. Ponadto u osób z ZM istotnie częściej stwierdzano deficytowe stężenie 25(OH)D niż u badanych bez ZM. Uzyskane wyniki wskazują na konieczność prowadzenia dalszych badań dotyczących stężenia 25(OH)D u osób z chorobami metabolicznymi, niezależnie od wielkości ekspozycji na promieniowanie UV i spożycia witaminy D z dietą.
PL
Tempo metabolizmu podstawowego (BMR) jest cechą określającą minimalne, energetyczne koszty przeżycia organizmu. Zwierzęta, w tym ludzie, różnią się pod względem wartości tej cechy. W 1999 roku Hulbert i Else, opierając się na licznych badaniach porównawczych zmiennocieplnych i stałocieplnych gatunków zwierząt o różnej masie ciała, zaproponowali mechanizm tłumaczący w prosty sposób obserwowaną zmienność BMR. Tak powstała teoria metronomu błonowego (ang. membrane pacemaker theory of metabolism), zgodnie z którą BMR zależy od składu lipidowego, a w konsekwencji płynności błon komórkowych. Praca ta wyjaśnia pojęcie tempa metabolizmu podstawowego, opisuje teorię metronomu błonowego, wskazuje na rolę desaturaz, tj. ważnych enzymów szlaku przemian kwasów tłuszczowych w kształtowaniu BMR, a także przybliża problematykę związaną z zespołem metabolicznym i procesami starzenia się oraz sugeruje praktyczne wykorzystanie opisanej teorii w komponowaniu codziennej diety człowieka.
EN
Basal metabolic rate (BMR) quantifies the minimal energetic cost of life of the organism. Animals, as well as humans, differ with respect to this trait. In 1999, based on the numerous comparative researches on ecotherms and endotherms species of animals that differ in body mass, Hulbert and Else have proposed the mechanism explaining in the simple way observed differences in BMR. They have formulated the membrane pacemaker theory of metabolism, according to which BMR depend on lipid composition of biological bilayers. This paper explains the concept of basal metabolic rate, describes the membrane pacemaker theory of metabolism, points out the role of desaturases in BMR, which are the important enzymes in fatty acids metabolism, and finally addresses the problem of metabolic syndrome, as well as suggests the practical usage of the theory described in the human daily food plan.
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