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Malignant mixed tumor of the skin: a case report and review of the literature

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Famulski W., Kańczuga- Koda L., Niewiarowska K., Niksa M., Maruszak K., Koda M., Pryczynicz A.
Progress in Health Sciences
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2013
|
vol. 3
|
issue 1
154-158
EN
Introduction: Malignant mixed tumor (MMT) is an exceedingly rare cutaneous adnexal carcinoma with a significant risk for aggressive behavior and a propensity for metastasis. This tumor occurs in a wide age range and is twice as common in woman than in men. MMT shows a predilection for the trunk and the extremist’s foremost hands and feet. MMT may be confused clinically with many benign and malignant lesions. Therefore the histopathological and immunohistochemical examination is required for the correct diagnosis and treatment. Purpose: To present a case of MMT localized in the left toe with a special attention focused on its histopathology and differential diagnosis. Case presentation: A 56-year-old female was admitted with a nodular lesion on the left toe. A painless mass had been presented for one year with a significant increase in size within the past three month. The patient underwent wide surgical excision. Histopathologically for the lesion was diagnosed it as a malignant mixed tumor. Immunohistochemical examination revealed positive reaction for cytokeratin AE1/AE3/PCK26, vimentin and S-100. Histochemical reaction for PAS in the chondromyxoid tumor stroma was negative. Conclusion: Correct histopathological diagnosis and complete excision with wide disease-free margins before metastasis result in MMT free survival.
2

Detection of PRL-3 protein in the preoperative serum of patients with colorectal cancer

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Pryczynicz A., Dymicka-Piekarska V., Niewiarowska K., Gryko M., Niksa M., Hawryluk M., Kemona A., Famulski W.
Progress in Health Sciences
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2013
|
vol. 3
|
issue 1
49-53
EN
Purpose: The aim of study was to detect PRL-3 protein in sera of patients with colorectal cancer. Methods: The study group consisted of 22 patients with colorectal carcinoma and 10 healthy controls. The serum concentration of PRL-3 protein was evaluated by the ELISA method. Results: In the study group with colorectal cancer, the level of PRL-3 protein in preoperative sera was negative (<0.115ng/ml) in 7 cases while the mean value of PRL-3 concentration was 0.616ng/ml (range 0.206-2.072ng/ml) in 15 patients. No statistically significant differences between the study group and healthy controls were observed. Our data showed that increase in level of PRL-3 protein in sera of patients with colorectal cancer is associated with greater tumor size (p<0.05). Conclusions: PRL-3 protein was found to be present in sera of patients with colorectal cancer. However, our study indicates lack of clinical usefulness of determining the levels of PRL-3 in the sera of patients with colorectal cancer.
3

A comparative analysis of chosen lesions of the uterine cervix in the population of women in Podlasie Province

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Borsuk A., Pryczynicz A., Niewiarowska K., Cepowicz D., Niksa M., Hawryluk M., Korniluk A., Famulski W.
Progress in Health Sciences
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2013
|
vol. 3
|
issue 1
44-48
EN
Purpose: In Poland, cervical screening tests are performed in the group of women aged 25 to 59 years. The aim of the study was to evaluate the usefulness of the Bethesda System in assessing cervical smears. Methods: Results of gynecological cytologies performed in the UPDC in the period of 01 August 2011 – 31 July 2012 were analyzed. Of the material, cases subjected to histopathological analysis in correlation with cytological outcome were chosen. Results: Of 19,887 patients who underwent cytology, 603 had atypical epithelial cells. In 83/603 cases, histopathological specimens were available for analysis. The level of cytological and histopathological compatibility was the highest in the HSIL group (75%), being the lowest in patients with LSIL (40%). It should be emphasized that in HSIL cases, histological specimens showed no evidence of normality. Conclusions: The level of cytological and histopathological compatibility was the highest in the HSIL group (75%). The compatibility was the lowest in the LSIL group (40%). It should be emphasized that in HSIL cases, histological specimens showed no evidence of normality.
4

The presence of metastatic melanoma in the small intestine is associated with a poor prognosis - A Report of two cases

84%
Niewiarowska K., Pryczynicz A., Malla H., Łuba M., Dadan J., Kemona A., Niksa M., Famulski W.
Progress in Health Sciences
|
2013
|
vol. 3
|
issue 1
148-153
EN
Introduction: Malignant melanoma is a neoplasm arising from the melanocyte cells of the skin. Of all cancers diagnosed in Poland in 2009, it was the twelfth most-common cancer in men and the fourteenth in women. However, this type of cancer is characterized by a quick development of metastases and a high mortality rate. Melanoma usually metastasizes to the lymph nodes, then infiltrates the lungs, brain, liver, bones, and gastrointestinal tract, for example, the small intestine. Purpose: To present two cases of metastatic melanoma with a poor prognosis involving the small intestine. Case presentation: In the first case, a 50-year-old male patient with abdominal pain and distension was admitted to hospital and qualified for surgical treatment. The second case, a 45-year-old male patient, presented with severe abdominal pain and sudden obstruction of the gastrointestinal tract. Both patients had previous medical histories of malignant melanoma found on the skin of the subscapular area. The pathomorphological reports confirmed metastatic melanoma of the small bowel. The patients underwent partial resection of the small bowel with end-to-end anastomosis. Conclusion: Patients with metastatic melanoma originating from the small intestine had a poor prognosis. Due to the difficult diagnostic control of melanoma that develops on the skin and insufficient therapy for advanced stage cancer, we should develop early diagnostics for cutaneous melanoma through cancer prevention education in the population.
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