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DIPNECH – a preneoplastic lesion or a separate biological entity?

100%
Dawidziuk T., Sawicka E., Chyczewski L.
Progress in Health Sciences
|
2013
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vol. 3
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issue 2
160-164
EN
Introduction: DIPNECH is a very rare condition with under 100 cases reported in the scientific literature worldwide. The new WHO classification of lung tumors considers it as a preneoplastic condition, leading to further growth of pulmonary carcinoid tumors. Prior to that, proliferating neuroendocrine, or NE cells in the respiratory epithelium develop into tumorlets – lesions less than 5mm in the largest size, visible in diagnostic imaging as round shadows and sometimes mistake for metastases of a tumor of unknown origin. Purpose: The goal here is to strongly recommend the foundation of a world wide web (www) based portal with clinical information about DIPNECH, also, if possible, containing reports of all the cases ever diagnosed. This will create an easily accessible source of information, which could increase the rate of diagnosis for this condition. Thanks to further possibilities of scientific exchange and development such as a database could become a vast archive of pulmonary preneoplastic lesions with possible clues to understanding mechanisms of carcinogenesis. Discussion: It is yet unclear, if DIPNECH could be a predecessor of other neuroendocrine tumors, at least being one of their possible origins, or is the growth of NE cells around the primary neuroendocrine tumor a reaction for airway obstruction and hypoxia. Conclusion: According to information gathered through electronic search, further scientific investigation of DIPNECH might be very helpful in understanding carcinogenesis in lung.
2

Assessment of prevalence of HPV DNA in colorectal adenocarcinoma in patients from the Podlasie region

64%
Miąsko A., Chomczyk M., Pancewicz–Wojtkiewicz, J, Roszkowski A., Kędra B., Borzym - Kluczyk M., Szynaka B., Chyczewski L.
Progress in Health Sciences
|
2012
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vol. 2
|
issue 2
84-89
EN
Purpose: The aim of the study was to assess the prevalence of human papillomavirus (HPV) DNA in colorectal adenocarcinoma in patients from the Podlasie region undergoing surgery for the tumor. Materials and methods: We examined 40 solid colorectal tumors taken during surgical treatment at the 2nd Department of General and Gastrointestinal Surgery, Medical University of Białystok. HPV was detected by means of polymerase chain reaction (PCR) and in situ hybridization (ISH). The tests were performed on formalin-fixed, paraffin-embedded tumor tissue. Two pairs of primers were used for the detection of HPV DNA by PCR. Pair pU-1M/pU-2R enables detection and identification of high-risk HPV (HPV 16, 18, 31, 33, 35, 52b, 58), while pair pU-31B/pU-2R enables detection and identification of low-risk HPV (HPV 6, 11). The ISH was performed with the use of biotin-labelled dsDNA probes, using Wide Spectrum HPV DNA Probe Cocktail Biotinylated kit, DAKO Cyto-mation. Results: HPV DNA was found in 21 (52.5%) of the examined colorectal tumors. The PCR revealed the presence of viral DNA in 19 (47.5%) tumors. The ISH revealed the presence of HPV DNA in 16 (40%) of the examined tumors. Conclusion: The findings of this study correlate with similar results conducted by other research groups. However, this is the first study of colorectal tumor samples taken from patients of the Podlasie region. Therefore, the association between environmental factors, HPV infection, and tumor stage should also be verified in a larger study population. Further studies confirming the presence of HPV DNA in colorectal tumor tissue in populations from different regions of Poland are needed.
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