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Analysis risk factors for preterm births in children under care of the Department of Pediatric Rehabilitation in Bialystok

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Dytrych G., Sienkiewicz D.
Progress in Health Sciences
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2018
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vol. 8(2)
99-104
EN
Introduction: Preterm birth is the birth of a baby at fewer than 37 weeks' gestational age. Preterm infants are at risk for numerous medical problems including neurological, cardiological, respiratory, and infection. Purpose: To analyse the selected risk factors of preterm births among children under the care of the Department of Pediatric Rehabilitation in Białystok Materials and methods: The retrospective study included 96 preterm children with very low body mass less than 1500 grams. All children lived in the Podlasie region of Poland. We analysed the risk factors for preterm birth based on the medical files. The detailed interview included: the course of pregnancy, diseases before pregnancy, the prevalence of genetic diseases in the nearest family, and the earlier miscarriages. Results: The intrauterine infection (20 cases), fetal distress, (19 cases), uterine bleeding (15 cases), multiple pregnancies (13 cases) were the most often risk factors of preterm births. Only a few cases concerned congenital toxoplasmosis and cytomegaly, malformation of the reproductive system, mother diseases during the pregnancy. The gender of the child did not determine the preterm birth. A significant correlation between preterm birth and the sequence of pregnancy preterm birth was related with first pregnancy in 47% of cases. There was no correlation between i. body mass and sex, ii. earlier miscarriages and preterm births. Conclusions: The risk factors of preterm births are diverse. Most common causes of preterm births were the intrauterine infection, fetal distress, and uterine bleeding.
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Granulocyte colony-stimulating factor potential use in the treatment of children with cerebral palsy

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Paszko-Patej G., Sienkiewicz D., Okurowska-Zawada B., Kułak W.
Progress in Health Sciences
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2017
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vol. 7(1)
187-192
EN
Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery. G-CSF exerts neuroprotective actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis. This review highlights recent studies on the potential use of G-CSF in cerebral palsy.
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Progressive paraparesis in 14 - year-old male with kyphoscoliosis: A case report

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Okurowska-Zawada B., Kułak W., Sienkiewicz D., Paszko-Patej G.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
203-206
EN
A 14-year-old male presented with congenital kyphoscoliosis along with progressive paraparesis. Radiographs confirmed kyphoscoliosis and magnetic resonance imaging revealed a stretched and flattened spinal cord over the kyphotic deformity and a T6 hemivertebra. Before the surgical treatment the patient had clinical signs and symptoms of paraparesis. A gradual deterioration in the neurologic status was observed and patient became paraplegic after the surgery. Currently, the patient moves in a wheelchair, has a pyramidal syndrome of the lower limbs and neurogenic bladder.
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Cell therapy: a new hope for treatment of cerebral palsy ?

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Kułak W., Okurowska-Zawada B., Sienkiewicz D., Paszko-Patej G.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
174-180
EN
Cerebral palsy (CP) is the most frequent neurological disorder associated with perinatal injury of the developing brain. The beneficial impact of stem cells (neural stem cells, mesenchymal stem cells, and embryonic stem cells) is mediated through soluble trophic factors and other cytokines that enable the body to re-establish homeostasis after pathologic and traumatic insults, inflammation, and tissue infarction or degeneration. There is currently no effective therapy for CP. Recently there have been notable advances in the application of cell therapy in neurological disorders. This review provides recent data on the prevention and cell therapy in CP.
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The physical and occupational activity of patients with multiple sclerosis depending on the form of clinical disease

81%
Wyszyńska E., Sienkiewicz D., Kułak W.
Progress in Health Sciences
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2019
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vol. 1
126-131
EN
Introduction: The progressive nature of multiple sclerosis (MS) is associated with numerous neurological deficits, leading gradually to deteriorating health and to disability. Purpose: The aim of this study was a subjective assessment of the physical and occupational activity of individuals with MS depending on the clinical form of the disease. Materials and methods: We used the original to conduct the research, with 28 closed questions. The study was carried out from December 1, 2018, to January 31, 2019, following approval by the Bioethics Committee of the Medical University of Bialystok, among persons belonging to the Association for Helping Sick People for Multiple Sclerosis in Białystok and patients of the Neurology Department of the University Clinical Hospital in Bialystok. The study sample comprised 50 people diagnosed with MS, 41 women and 9 men. Results: The most frequently occurring clinical form of MS was relapsing-remitting (68%). In this form, most participants had good physical fitness (44%). In those with the progressive-recurrent form (50%), very poor physical fitness was subjectively noted. Of those with the relapsing-remitting type of MS, 50% were professionally active, while none of the participants with the progressive-recurrent form were. Both the physical and occupational activities of MS patients were frequently limited by fatigue, balance disturbances, and movement difficulties. Fatigue was the most common symptom for most individuals with MS (82%). Conclusion: MS has a significant impact on both the physical activity and occupational functioning of patients. In the clinical form of MS, relapsing-remitting, patients’ physical fitness was better.
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Neurologic adverse events following vaccination

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Sienkiewicz D., Kułak W., Okurowska-Zawada B., Paszko-Patej G.
Progress in Health Sciences
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2012
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vol. 2
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issue 1
129-141
EN
The present review summarizes data on neurological adverse events following vaccination in the relation to intensity, time of onset, taking into account the immunological and non-immunological mechanisms. The authors described the physio-logical development of the immune system and the possible immune system responses following vaccination. Toxic property of thimerosal - a mercury-containing preservative used in some vaccines was presented. The neurological compli-cations after vaccination were described. The role of vaccination in the natural course of infectious diseases and the current immunizations schedule in Poland was discussed.
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Volumetric magnetic resonance imaging of gastrocnemius muscle in a patient with facioscapulohumeral dystrophy

71%
Gościk E., Kułak P., Sienkiewicz D., Kułak W., Okurowska-Zawada B.
Progress in Health Sciences
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2013
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vol. 3
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issue 2
175-177
EN
Introduction: Magnetic resonance imaging (MRI) is a nonradiographic, non-invasive method to visualize and quantify muscle cross-sectional areas and volumes. Purpose: To evaluate a gastrocnemius muscle volume in a 15-year-old male with facioscapulo-humeral dystrophy (FSHD) using MRI. Material and methods: The patient with FSHD was given subcutaneously recombinant human granulocyte colony-stimulating factor - filgrastim (5μg/kg body/day) for 5 consecutive days during the first, second, and third months. The Siemens Magnetom 0.3T MRI scanner was used to acquire the images of the right calf of the patient. The analysis of MR images used advanced biomedical imaging software-Analyze 10 Biomedical Imaging Software. Results: The patient with FSHD after 6 month of the treatment compared with baseline had greater volume of the gastrocnemius muscle volume of the right calf. Muscle volume increased from 60,567.5 mm3 to 70,795.6 mm3. The increased of muscle volume of this patient correlated with the improvements of muscle strength and EMG. Conclusion: MR imaging can provide quantitative, reproducible volumetric measures of muscles in the patients with FSHD.
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An unusual case of burst cervical spinal fracture of a 15-year-old boy complicated by venous thrombosis and neurogenic heterotopic ossification

71%
Sienkiewicz D., Kułak W., Gościk E., Okurowska-Zawada B., Paszko-Patej G.
Progress in Health Sciences
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2011
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vol. 1
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issue 2
192-195
EN
The authors report an unusual case of a 15-year-old boy who dove into a shallow lake and suffered a cervical fracture of C5 affecting the spinal cord. This resulted in tetraplegia. Vitamin D3 deficiency and a history of several bone fractures supported an idea that the patient's bone structure had been weakened. The deep vein thrombosis of lower limb and neurogenic heterotopic ossification of a hip limited the effectiveness of physical therapy.
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Quality of life of parents of children with cerebral palsy

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Okurowska –Zawada, B, Kułak W., Wojtkowski J., Sienkiewicz D., Paszko-Patej G.
Progress in Health Sciences
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2011
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vol. 1
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issue 1
116-123
EN
Purpose: The aim of the study was to assess the quality of life of parents of children with cerebral palsy. Materials and methods: The study included 40 parents of children with cerebral palsy treated at the Department of Pediatric Rehabilitation of the Medical University of Bialystok. The WHOQOL-BREF questionnaire was used as a research tool; it enables obtaining a quality of life profile in four domains: physical health, psychological, social relationships and environment. The severity of a child's movement disorders was assessed using the Gross Motor Function Classification System (GMFCS). Results: In the studied group of parents of children with cerebral palsy, more than half described their quality of life as good and was pleased with their health. The largest differences occurred in parents of children with cerebral palsy in the environment domain, p=0.0068, and the psychological domain, p=0.010. Quality of life in all four domains was assessed as lower in parents of children with cerebral palsy compared with parents of healthy children. Only in the evaluation of health care facilities parents of children with cerebral palsy assessed them better than parents of healthy children. Conclusion: Parents of children with cerebral palsy describe their quality of life as good and are satisfied with their health.
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Effects of short moderate exercise on hematological parameters and stem cells in healthy humans

52%
Sochoń K., Sienkiewicz D., Okurowska-Zawada B., Paszko-Patej G., Wojtkowski J., Dmitruk E., Żak J., Kułak W.
Progress in Health Sciences
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2016
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vol. 6(2)
184-187
EN
Introduction: Exercise at various durations and intensities impact on blood and stem cells. This pilot study examined the effects of 30 minutes of treadmill walking on hematological indices and progenitor stem cells CD34+ in healthy subjects. Materials and methods: A total of 17 non-smoking, healthy students, aged 20 to 22 years participated. Hemoglobin, hematocrit, white blood cells, platelets, and stem cell CD34+ numbers were assessed before and after moderate exercise. Statistical analyses examined the relationships between CD34+ cells versus hematological indices, age, and body mass index. Results: Following exercise, significant increases were observed in leukocytes, neutrophils, eosinophils, and CD34+ cells numbers. For CD34+ cells, a fourfold increase was seen. Significant correlations between CD34+ cells, white blood cells, and neutrophils were found. Conclusion: Our results suggest that moderate exercise has a physiological impact on hematologic parameters and stem cells CD34+ in healthy subjects. Furthermore, our findings suggest that brief treadmill exercise may enhance tissue repair mechanisms so important in physiotherapy.
11
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Effects of granulocyte colony-stimulating factor treatment in children and patients with cerebral palsy: a preliminary report

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Paszko-Patej G., Kułak W., Okurowska-Zawada B., Sienkiewicz D., Wojtkowski J., Sochoń K., Kalinowska A., Okulczyk K., Topór E., Mirska A.
Progress in Health Sciences
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2017
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vol. 7(1)
78-82
EN
neuroinflammation and apoptosis in brains affected by cerebral palsy could be therapeutic targets. Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain. Purpose: To assess the efficacy and safety of G-CSF treatment in children and adolescents with CP. Materials and methods: Six patients with spastic tetraplegia CP aged 3-15 years were enrolled in this study. Five patients had GMFCS (Gross Motor Function Classification System) level at V, three children had epilepsy, and three had severe mental retardation. We used the gross motor function measure-66 (GMFM-66) to assess motor function.GCSF (5μg/kg/body/day) was administered subcutaneously for five consecutive days during the four months. The parents also evaluated the physical and mental development of their children. Results: We observed improvement in motor function in patients with CP on the GMFM-66 scale. Parents reported improvement in behavior, speech development, and a decrease in spasticity in children with CP. G-CSF therapy was well-tolerated. No side effects were observed during the study. Conclusions: Our preliminary report suggests that G-CSF treatment improves motor and mental function in patients with CP. Further studies are needed to confirm these observations
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Safety and efficacy of granulocyte colony stimulating factor in a patient with tetraplegia caused by cervical hyperextension injury: a case report

52%
Okurowska-Zawada B., Kułak W., Sienkiewicz D., Paszko-Patej G., Dmitruk E., Kalinowska A., Wojtkowski J., Korzeniecka–Kozerska, A
Progress in Health Sciences
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2014
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vol. 4
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issue 2
181-184
EN
he authors present the case of a 17-year-old boy who suffered a cervical spinal injury as a result of the sharp bending of the head after slipping (without falling). After about 30 minutes, he began to feel tingling in the limbs and he developed tetraparesis. He went through physical rehabili-tation, psychological rehabilitation, occupational therapy, and periodic catheterization. Additionally, we introduced to him a low dose of analog granulocyte colony-stimulating factor (G-CSF). G-CSF 5 μg/kg was given subcutaneously daily for 5 days per month for 3 months, again after 6 months, and again after 10 months. The boy could sit indecently and walk with assistance. A significant increase in muscle strength in this patient with tetraplegia after 10 months of treatment may indicate beneficial effects of G-CSF in this disorder.
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Quality of life of children suffering from motor disabilities as evaluated by their parents

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Wojtkowski J., Sienkiewicz D., Okurowska-Zawada B., Paszko-Patej G., Konopka A., Okulczyk K., Średzińska K., Dmitruk E., Mirska A., Kułak W.
Progress in Health Sciences
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2017
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vol. 7(2)
60-66
EN
Purpose: We assessed the quality of life of children with motor disabilities in comparison with healthy children, as evaluated by their parents, using the CHQ-PF28 questionnaire (Child Health Questionnaire—Parent Form). Materials and methods: In a prospective study, we evaluated the quality of life of 105 children with motor disabilities. Results: Our research showed lower quality of life in the group of children with motor disabilities compared with controls, both in terms of physical and psychosocial health. Significant correlations between independent walking and physical functioning, general behavior, and mental health of children suffering from motor disabilities were found. According to the average indices of quality of life of children suffering from motor disabilities, depending on sex, the greatest differences occurred in behavior and change of health status, while the smallest differences in self-esteem and parental involvement, compared with controls. In the case of healthy children, the largest differences appeared in the perception of pain, behavior, and self-esteem; whereas, the smallest variations occurred in the change of health status and physical activity. Conclusion: Children suffering from motor disabilities demonstrate lower quality of life compared with healthy children.
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Effects of granulocyte colony-stimulating factor therapy for osteogenesis imperfecta: a case report

52%
Paszko-Patej G., Sienkiewicz D., Kułak W., Okurowska-Zawada B., Wojtkowski J., Kalinowska A., Okulczyk K., Sochoń K., Dmitruk E., Mirska A.
Progress in Health Sciences
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2017
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vol. 7(1)
205-208
EN
Introduction: Osteogenesis imperfecta (OI) is a genetic disorder of increased bone fragility and low bone mass. OI type IV. Materials and methods: We examined the safety and effectiveness of a low dose of analog granulocyte colony-stimulating factor (G-CSF) in a 15-year-old girl OI type IV. G-CSF 5 μg/kg was given subcutaneously, for 5 days/month for 3, 6 and 12 months. Laboratory tests, including blood, biochemical tests were performed, in addition to clinical examination.Results: Clinical examination revealed an increase of muscle strength in the upper and lower limbs between base line and day 6 and 12 months. We found no serious adverse events. Leukocyte levels remained below 38,000/μL. Low dose G-CSF was safe and well tolerated by the patient. Conclusions: A significant increase in muscle strength in this patient may indicate beneficial effects of G-CSF factor in this disorder. These results are inspiring and warrant further studies.
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Granulocyte colony-stimulating factor therapy for facioscapulohumeral dystrophy: a case report

42%
Sienkiewicz D., Kułak W., Okurowska-Zawada B., Paszko-Patej G., Wojtkowski J., Dmitruk E., Okulczyk K., Sochoń K., Kalinowska A., Żak J., Pogorzelski R.
Progress in Health Sciences
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2016
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vol. 6(2)
175-177
EN
We examined the safety and effectiveness of a low dose of analog granulocyte-colony stimulating factor in a 15-year-old boy with facioscapulohumeral dystrophy. The onset of disease was noted at 12 years of age. The physical examination noted general muscle atrophy more pronounced at left side of the body. He was able to walk 300 meters within 6 minute walk test. Granulocyte colony-stimulating factor 5 μg/kg was given subcutaneously daily for 5 days/month for 1, 2, 3, 6 and 12 months. Clinical examination, laboratory tests including blood, biochemical tests, and CD34+ cells were performed. A significant increase of muscle strength in the lower and upper limbs between baseline, and after 3 months of treatment, after 6, and after 12 months was found. He was able to walk 480 meters within 6 minutes after 12 months. Electromyography demonstrated increase of amplitude in the examined in upper and lower limbs after six months compared to baseline. Leukocyte levels remained below 25000/μL. CD34+ increased significantly at day 5 of granulocyte colony-stimulating factor admini-stration. It was safe and well tolerated by the patient. A significant increase in muscle strength in this patient with facioscapulohumeral dystrophy after 3 months of treatment, after 6, and after 12 months since the first treatment course was completed may indicate beneficial effects of granulocyte colony-stimulating factor in this disorder.
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