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1

Malignant mixed tumor of the skin: a case report and review of the literature

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Famulski W., Kańczuga- Koda L., Niewiarowska K., Niksa M., Maruszak K., Koda M., Pryczynicz A.
Progress in Health Sciences
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2013
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vol. 3
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issue 1
154-158
EN
Introduction: Malignant mixed tumor (MMT) is an exceedingly rare cutaneous adnexal carcinoma with a significant risk for aggressive behavior and a propensity for metastasis. This tumor occurs in a wide age range and is twice as common in woman than in men. MMT shows a predilection for the trunk and the extremist’s foremost hands and feet. MMT may be confused clinically with many benign and malignant lesions. Therefore the histopathological and immunohistochemical examination is required for the correct diagnosis and treatment. Purpose: To present a case of MMT localized in the left toe with a special attention focused on its histopathology and differential diagnosis. Case presentation: A 56-year-old female was admitted with a nodular lesion on the left toe. A painless mass had been presented for one year with a significant increase in size within the past three month. The patient underwent wide surgical excision. Histopathologically for the lesion was diagnosed it as a malignant mixed tumor. Immunohistochemical examination revealed positive reaction for cytokeratin AE1/AE3/PCK26, vimentin and S-100. Histochemical reaction for PAS in the chondromyxoid tumor stroma was negative. Conclusion: Correct histopathological diagnosis and complete excision with wide disease-free margins before metastasis result in MMT free survival.
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Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer

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Grudzińska M., Jakubowska K., Kańczuga-Koda L., Kisielewski W., Famulski W., Smereczański N., Lomperta K., Płoński M., Rogoz-Jezierska N., Koda M.
Progress in Health Sciences
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2020
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vol. 10(1)
69-76
EN
Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cancer
3

Detection of PRL-3 protein in the preoperative serum of patients with colorectal cancer

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Pryczynicz A., Dymicka-Piekarska V., Niewiarowska K., Gryko M., Niksa M., Hawryluk M., Kemona A., Famulski W.
Progress in Health Sciences
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2013
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vol. 3
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issue 1
49-53
EN
Purpose: The aim of study was to detect PRL-3 protein in sera of patients with colorectal cancer. Methods: The study group consisted of 22 patients with colorectal carcinoma and 10 healthy controls. The serum concentration of PRL-3 protein was evaluated by the ELISA method. Results: In the study group with colorectal cancer, the level of PRL-3 protein in preoperative sera was negative (<0.115ng/ml) in 7 cases while the mean value of PRL-3 concentration was 0.616ng/ml (range 0.206-2.072ng/ml) in 15 patients. No statistically significant differences between the study group and healthy controls were observed. Our data showed that increase in level of PRL-3 protein in sera of patients with colorectal cancer is associated with greater tumor size (p<0.05). Conclusions: PRL-3 protein was found to be present in sera of patients with colorectal cancer. However, our study indicates lack of clinical usefulness of determining the levels of PRL-3 in the sera of patients with colorectal cancer.
4

Fine needle aspiration cytology in the diagnosis of Sjögren’s syndrome

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Pryczynicz A., Guzińska-Ustymowicz K., Wakulewska A., Ducher M., Lewczuk Ł., Kisielewski W., Ustymowicz A., Zioło M., Famulski W.
Progress in Health Sciences
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2013
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vol. 3
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issue 2
178-182
EN
Introduction: Sjögren’s syndrome is an autoimmune disease belonging to the group of collagenases. It is characterized by lymphocytic infiltration of the exocrine glands, leading to their impairment or complete dysfunction. The inflammatory process usually involves cells of the salivary or lacrimal glands. However, also other organs and systems can be affected. Purpose: The presentation of a Sjögren’s syndrome case. The pathologist’s role in the disease diagnosis. Case presentation: A 63-year-old female patient with the enlarged left parotid salivary gland and symptoms of xerostomia and xerophtalmia was referred for ultrasound imaging and fine-needle aspiration biopsy (FNAB). Ultrasonography revealed inhomogeneous echostructure of the salivary gland with multiple tiny, oval, hypoechoic areas, hyperechoic zones of fibrosis and enhanced vascularization of the gland. The pathological analysis of FNA showed a benign lymphoepithelial lesion, and Sjögren’s syndrome was suggested. Blood serum analysis found anti Ro-52 (SS-A), anti-La (SS-B) and anti-ANA antibodies at 1:1,000 titer. Sjögren’s syndrome was diagnosed based on accessory investigations and the clinical condition of the patient. Conclusions: The pathomorphological analysis of fine-needle aspiration biopsy of the salivary gland contributed to the diagnosis of Sjőgren’s syndrome in the patient.
5

A comparative analysis of chosen lesions of the uterine cervix in the population of women in Podlasie Province

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Borsuk A., Pryczynicz A., Niewiarowska K., Cepowicz D., Niksa M., Hawryluk M., Korniluk A., Famulski W.
Progress in Health Sciences
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2013
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vol. 3
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issue 1
44-48
EN
Purpose: In Poland, cervical screening tests are performed in the group of women aged 25 to 59 years. The aim of the study was to evaluate the usefulness of the Bethesda System in assessing cervical smears. Methods: Results of gynecological cytologies performed in the UPDC in the period of 01 August 2011 – 31 July 2012 were analyzed. Of the material, cases subjected to histopathological analysis in correlation with cytological outcome were chosen. Results: Of 19,887 patients who underwent cytology, 603 had atypical epithelial cells. In 83/603 cases, histopathological specimens were available for analysis. The level of cytological and histopathological compatibility was the highest in the HSIL group (75%), being the lowest in patients with LSIL (40%). It should be emphasized that in HSIL cases, histological specimens showed no evidence of normality. Conclusions: The level of cytological and histopathological compatibility was the highest in the HSIL group (75%). The compatibility was the lowest in the LSIL group (40%). It should be emphasized that in HSIL cases, histological specimens showed no evidence of normality.
6
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Systemic inflammation markers in blood samples of colorectal cancer patients

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Grudzińska M., Jakubowska K., Koda M., Koda L., Kisielewski W., Smereczański N., Rogoz-Jezierska N., Famulski W.
Progress in Health Sciences
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2020
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vol. 10(1)
92-101
EN
Introduction: Colorectal cancer (CRC) is one of the most common cancers in Poland. The aim of this study was to investigate the clinical significance of absolute monocyte count, neutrophil-to-monocyte ratio (NMR) and monocyte­to­lymphocyte ratio (MLR) in pre- and postoperative blood samples of patients with CRC. Materials and Methods: We retrospectively reviewed medical records of 160 patients diagnosed with CRC who underwent surgery. Blood samples were obtained within 3 days before and after the surgical treatment. Venous blood samples were also obtained from 42 healthy controls. Results: Pre- and postoperative NMR were significantly higher than healthy controls (p<0.0001; p<0.0001). Moreover, MLR in pre-and postoperative blood samples were higher than voluntaries (p<0.001; p<0.001). The area under the ROC curve for pre and postNMR showed that the parameter exhibits strong diagnostic power (1.000). Pre- and postMLR had moderate diagnostic power amount 0.751 and 0.746. There is also correlation between monocyte count in samples obtained before and after surgery and, lymph node metastasis and size of lymph node metastasis in both cases. PreNMR value was significantly associated with venous and lymphatic invasion and the presence of cancer deposits. PostNMR was found to correlate with presence of distant metastasis and cancer cell deposits (R=0.633, p<0.001; R=0.158, p=0.040). Moreover, preMLR value was correlated with only perineural invasion. Conclusions: Analyzed hematologic markers may be useful as simply obtained parameters, next to histopathological examination, that determine a systemic immune response
7

The presence of metastatic melanoma in the small intestine is associated with a poor prognosis - A Report of two cases

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Niewiarowska K., Pryczynicz A., Malla H., Łuba M., Dadan J., Kemona A., Niksa M., Famulski W.
Progress in Health Sciences
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2013
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vol. 3
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issue 1
148-153
EN
Introduction: Malignant melanoma is a neoplasm arising from the melanocyte cells of the skin. Of all cancers diagnosed in Poland in 2009, it was the twelfth most-common cancer in men and the fourteenth in women. However, this type of cancer is characterized by a quick development of metastases and a high mortality rate. Melanoma usually metastasizes to the lymph nodes, then infiltrates the lungs, brain, liver, bones, and gastrointestinal tract, for example, the small intestine. Purpose: To present two cases of metastatic melanoma with a poor prognosis involving the small intestine. Case presentation: In the first case, a 50-year-old male patient with abdominal pain and distension was admitted to hospital and qualified for surgical treatment. The second case, a 45-year-old male patient, presented with severe abdominal pain and sudden obstruction of the gastrointestinal tract. Both patients had previous medical histories of malignant melanoma found on the skin of the subscapular area. The pathomorphological reports confirmed metastatic melanoma of the small bowel. The patients underwent partial resection of the small bowel with end-to-end anastomosis. Conclusion: Patients with metastatic melanoma originating from the small intestine had a poor prognosis. Due to the difficult diagnostic control of melanoma that develops on the skin and insufficient therapy for advanced stage cancer, we should develop early diagnostics for cutaneous melanoma through cancer prevention education in the population.
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