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Purpose: Assessment of pain intensity in patients with chronic low back pain in correlation with the clinical picture and illness acceptance. Material and methods: The study group included 120 patients (67 males and 53 females) aged 43.07 ± 8.74 years (range: 18 – 62 years) diagnosed with lumbosacral spine discopathy. The study was conducted between 2008 - 2010. Assessment tools used for the study included: pain intensity scale and Acceptance of Illness Scale (AIS). Results: Most often the pain was reported in the L4-L5 level of the lumbar spine. The duration of the illness ranged between 1-31 years (6.90 ± 6.47). The majority of the patients in the studied group were physical workers. Nearly half of the patients, 59 (49.16%) described their pain as moderate on a 5-point pain scale. No acceptance of illness according to the AIS scale was noted in 33 (27.5%) patients, the remaining 67 (72.5%) patients declared quite good and average good illness acceptance. We found no significant dependencies of the frequency of pain occurrence, pain intensity, its duration and the type of work. Conclusions: Pain reported due to chronic low back pain by the majority of the patients was of moderate intensity. No correlation was found between the pain and illness acceptance.
EN
Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the blood. Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery. G-CSF exerts neuroprotective actions through the inhibition of apoptosis and inflammation, and the stimulation of neurogenesis. This review highlights recent studies on the potential use of G-CSF in cerebral palsy.
EN
A 14-year-old male presented with congenital kyphoscoliosis along with progressive paraparesis. Radiographs confirmed kyphoscoliosis and magnetic resonance imaging revealed a stretched and flattened spinal cord over the kyphotic deformity and a T6 hemivertebra. Before the surgical treatment the patient had clinical signs and symptoms of paraparesis. A gradual deterioration in the neurologic status was observed and patient became paraplegic after the surgery. Currently, the patient moves in a wheelchair, has a pyramidal syndrome of the lower limbs and neurogenic bladder.
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Cerebral palsy (CP) is the most frequent neurological disorder associated with perinatal injury of the developing brain. The beneficial impact of stem cells (neural stem cells, mesenchymal stem cells, and embryonic stem cells) is mediated through soluble trophic factors and other cytokines that enable the body to re-establish homeostasis after pathologic and traumatic insults, inflammation, and tissue infarction or degeneration. There is currently no effective therapy for CP. Recently there have been notable advances in the application of cell therapy in neurological disorders. This review provides recent data on the prevention and cell therapy in CP.
EN
Introduction: The progressive nature of multiple sclerosis (MS) is associated with numerous neurological deficits, leading gradually to deteriorating health and to disability. Purpose: The aim of this study was a subjective assessment of the physical and occupational activity of individuals with MS depending on the clinical form of the disease. Materials and methods: We used the original to conduct the research, with 28 closed questions. The study was carried out from December 1, 2018, to January 31, 2019, following approval by the Bioethics Committee of the Medical University of Bialystok, among persons belonging to the Association for Helping Sick People for Multiple Sclerosis in Białystok and patients of the Neurology Department of the University Clinical Hospital in Bialystok. The study sample comprised 50 people diagnosed with MS, 41 women and 9 men. Results: The most frequently occurring clinical form of MS was relapsing-remitting (68%). In this form, most participants had good physical fitness (44%). In those with the progressive-recurrent form (50%), very poor physical fitness was subjectively noted. Of those with the relapsing-remitting type of MS, 50% were professionally active, while none of the participants with the progressive-recurrent form were. Both the physical and occupational activities of MS patients were frequently limited by fatigue, balance disturbances, and movement difficulties. Fatigue was the most common symptom for most individuals with MS (82%). Conclusion: MS has a significant impact on both the physical activity and occupational functioning of patients. In the clinical form of MS, relapsing-remitting, patients’ physical fitness was better.
EN
The present review summarizes data on neurological adverse events following vaccination in the relation to intensity, time of onset, taking into account the immunological and non-immunological mechanisms. The authors described the physio-logical development of the immune system and the possible immune system responses following vaccination. Toxic property of thimerosal - a mercury-containing preservative used in some vaccines was presented. The neurological compli-cations after vaccination were described. The role of vaccination in the natural course of infectious diseases and the current immunizations schedule in Poland was discussed.
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Purpose: The assessment of the antifungal activity of 59 new synthesized compounds. We compared the antifungal activity of N,N-phenyl-1,2,3,4-thiatriazole-5-yl-2,4-b-resorcyl-carbothioamide (PTR), of n-3-(1,2,4-dithiazole-5-thione)--reso-rcylcarbothioamide (DTRTA), of N,N-phenyl-1,2,3,4-thiatriazol-5-yl-2,4-b-resorcyl-carbothio-amide (PHARA) against Candida albicans strains in vitro. Material and methods: We evaluated 59 samples of the compounds synthesized at the Department of Chemistry University of Agriculture in Lublin. In the first phase, we tested the selected three samples with the lowest value of MIC - PTR, DTRTA, and PHARA. A reference strain of C. albicans ATCC 10231 and 200 strains of C. albicans isolated from the patients was used. Results: The MIC values of the tested samples fluctuated between 19.6 - 200 mg/L. The tested compounds showed moderate antifungal activity against C. albicans with MIC values of 19.6 mg/L for PTR, 22.0 mg/L for DTRTA, and 19.6 mg/L for PHARA. We found significant (p<0.001) differences between mean MIC values for PTR, DTRTA, PHARA on RPMI medium compared with MIC values on Sabouraud’s and YNB medium. Similar results we found for the reference strains C. albicans ATCC 10231. The reference strain C. albicans ATCC 10231 had enzymatic activity of 14 from 19 hydrolases in the (APIZYM), after exposure PTR number of the active enzymes was 6, after exposure DTRTA – 9, after exposure PHARA – 6, respectively. Isolates of C. albicans from the patients had enzymatic activity of 16 from 19 hydrolases, after exposure PTR number of active enzymes was 11, after exposure DTRTA – 15, and after exposure PHARA - 11. Conclusion: The synthesized compounds PTR, DTRA and PHARA exert a moderate antifungal activity against the C. albicans strains in vitro.
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Purpose: To assess attitudes towards euthanasia among medical staff (hospice workers and nurses not working in hospice), nursing students and family members of patients in hospice. Materials and methods: The study group included 565 persons: 175 nursing students, 183 professio-nally-active nurses not working in hospice, 103 hospice workers and 104 family members of patients in hospice. We used the original questionnaire survey. Results: Nearly half of the nurses, 49.6% of the students, 71.8% of the hospice workers and 45.2% of the family members were opposed to active euthanasia, whereas, 24.6% of the nurses, 32.4% of the students, 19% of the family members and 9% of the hospice workers supported euthanasia. Nurses supported the following forms of euthanasia: stopping resuscitation (47.5%), discontinuing life-support equipment (24%), and lethal injection (12%). In the student group, 43.6% supported stopping resuscitation, 34.4% supported the withdrawal of life-support equipment, and 12.6% supported lethal injection. Almost 46% of family members of patients in hospice accepted discontinuing life-support equipment and 21.2% supported stopping resuscitation. Nearly 37% of hospice workers accepted stopping resuscitation and 28.6% supported the withdrawal of life-support equipment. Most hospice workers were opposed to active euthanasia while most of the nursing students supported it. Conslusion: The legalization of euthanasia was favored by most of the students; however, in contrast, it was rarely favored by the hospice workers
EN
The microclimate of a room has an impact on human well-being, physical and mental health, on work productivity and the preservation of good health. Several dozen species of bacteria can live in buildings and more than 400 species of fungi (mainly Aspergillus, Cladosporium, Penicillium, Fusarium genus). The presented results are studies from different health department suggesting the desirability of systematic microbiological testing, evaluation of fungal pathogens, and involving staff, patients, walls, floors, furniture units (hardware, underwear), and air. However the problem is a lack of unified Polish standards, the classes of microbiological indoor air and the lack of harmonization of existing rules for air sampling to assess air fungal pollution in the health care setting.
EN
Introduction: Magnetic resonance imaging (MRI) is a nonradiographic, non-invasive method to visualize and quantify muscle cross-sectional areas and volumes. Purpose: To evaluate a gastrocnemius muscle volume in a 15-year-old male with facioscapulo-humeral dystrophy (FSHD) using MRI. Material and methods: The patient with FSHD was given subcutaneously recombinant human granulocyte colony-stimulating factor - filgrastim (5μg/kg body/day) for 5 consecutive days during the first, second, and third months. The Siemens Magnetom 0.3T MRI scanner was used to acquire the images of the right calf of the patient. The analysis of MR images used advanced biomedical imaging software-Analyze 10 Biomedical Imaging Software. Results: The patient with FSHD after 6 month of the treatment compared with baseline had greater volume of the gastrocnemius muscle volume of the right calf. Muscle volume increased from 60,567.5 mm3 to 70,795.6 mm3. The increased of muscle volume of this patient correlated with the improvements of muscle strength and EMG. Conclusion: MR imaging can provide quantitative, reproducible volumetric measures of muscles in the patients with FSHD.
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Introduction: DNA banking is popular in many countries in the world but is little known in Poland. Purpose: Determine the knowledge and opinions of students of the Faculty of Health Sciences of the Medical University of Białystok about DNA banking. Material and methods: The study comprised 108 students who volunteered to participate. Data were collected on a questionnaire that was developed by researchers. Results: Most of the students (72%) had heard of DNA banking; 53.0% from TV, 32.4 % from the Internet, 14.3% from newspapers, and 11% at the University. Of the responding students, 53.4% answered that DNA banking is ethical and beneficial. Nearly 26% decided to bank their own DNA. According to 33.5% of the students, a DNA sample is venous blood. Only 27.2% of the respondents knew that DNA banking is conducted in Poland, but none of them could name the city where the bank operates. Nearly half of the students (53.5%) reported that DNA banking is a molecular backup. Almost all the respondents (92.8%) wanted to increase their knowledge about DNA banking. Conclusion: The students' knowledge about DNA banking is poor, however almost all the respondents wanted to increase their knowledge about DNA banking. The main source of students’ knowledge about DNA banking was TV and the Internet. Nearly one-fourth of the respondents wanted to bank their own DNA.
EN
The authors report an unusual case of a 15-year-old boy who dove into a shallow lake and suffered a cervical fracture of C5 affecting the spinal cord. This resulted in tetraplegia. Vitamin D3 deficiency and a history of several bone fractures supported an idea that the patient's bone structure had been weakened. The deep vein thrombosis of lower limb and neurogenic heterotopic ossification of a hip limited the effectiveness of physical therapy.
EN
Purpose: To determine the volume of the cerebellum in children with spastic cerebral palsy (CP) in relation to risk factors and motor development. Material and methods: The present study included 30 children with spastic CP, aged 2-17 years. The volume of the cerebellum was examined on sagittal magnetic resonance images (MRI) of the CP patients and on 33 healthy subjects. To estimate the total cerebellum volume of each subject we used Analyze 10 Biomedical Imaging Software. Results: Children with spastic CP (129726,2 ± 26040,72 mm3) had a significantly smaller mean of the cerebellum volume compared to controls (143122,5 ± 12351,10 mm3). No significant difference between the total cerebellar volume and gender in patients with CP was found. No significant relationship between cerebellar volume and birth weight, Apgar score, gestational age, and Gross Motor Function Classification System (GMFCS) level were noted. Positive correlations between birth weight, Apgar score, gestational age, and GMFCS level, between Apgar score and gestational age, or between gestational age and GMFCS level were found. Conclusion: Our results show that children with spastic CP had smaller volumes of the cerebellum as compared to controls.
EN
Introduction: The history of palliative care dates back to the 1950s. Purpose: To examine the perceptions of hospice workers and family members of hospice patients related to hospice care in Podlaskie province in Poland. Materials and methods: The present study included 103 hospice workers and 104 family members of patients in hospice. The survey approach was used. Results: 56.7% families and 95.1% hospice workers considered hospice comprehensive care for terminally ill patients. In all, 84.6% of the families and 91.3% of the staff thought positively about hospice. Lack of knowledge of family on dying patients (43.3% families and 61.2% hospice workers), low level of funding for hospices (50% families and 64.1% hospice workers) and a small number of hospices and palliative care clinics (47.1% families and 53.4% hospice workers) are the most common problems in palliative care. According to 78.8% of the families and 84.5% of the staff, a specialist of palliative medicine should work in hospice. 62.5% of the families and 75.7% of the hospice workers were convinced that a nurse with a specialization should also work in hospice. According to 92.9% of the families and 96.9% of the staff, the patient and their family receive support in hospice. Conclusions: Most of the respondents were convinced that hospice is an appropriate place for terminally ill patients. Lack of knowledge of family on dying patients, low level of funding for hospices, a small number of hospices and palliative care clinics are the most common problems in palliative care.
EN
Purpose: The aim of the study was to assess the quality of life of parents of children with cerebral palsy. Materials and methods: The study included 40 parents of children with cerebral palsy treated at the Department of Pediatric Rehabilitation of the Medical University of Bialystok. The WHOQOL-BREF questionnaire was used as a research tool; it enables obtaining a quality of life profile in four domains: physical health, psychological, social relationships and environment. The severity of a child's movement disorders was assessed using the Gross Motor Function Classification System (GMFCS). Results: In the studied group of parents of children with cerebral palsy, more than half described their quality of life as good and was pleased with their health. The largest differences occurred in parents of children with cerebral palsy in the environment domain, p=0.0068, and the psychological domain, p=0.010. Quality of life in all four domains was assessed as lower in parents of children with cerebral palsy compared with parents of healthy children. Only in the evaluation of health care facilities parents of children with cerebral palsy assessed them better than parents of healthy children. Conclusion: Parents of children with cerebral palsy describe their quality of life as good and are satisfied with their health.
EN
Introduction: Approximately 7,000 different ethnic groups and nations inhabit the earth, and most of the tensions among people stem from prejudice and intolerance. Purpose: To assess a student perception of foreign nations and cultures. Materials and methods: We used the original questionnaire to assess the views of 150 students from Poland and 102 students from Belarus. Results: Twenty percent of the Polish respondents indicated that Poland is a tolerant nation; in contrast, 70.6% of Belarusian students claim that theirs is a tolerant nation. Almost 57% of the Polish and 34.3% of the Belarusian students knew a person belonging to a national or ethnic minority. 37.4% of the Polish respondents and 12.7% of the Belarusians were convinced that tolerance among foreign nations has increased. Neither the Polish nor the Belarusian students wanted to have as a neighbor, partner or spouse, a colleague at school who was a drug addict, homosexual or HIV positive. Nearly 40% of the Polish and 77.5% of the Belarusian respondents indicated that national minorities could have the opportunity to learn their language by accessing extra lessons offered at school. Fifty-eight percent from Poland and 52.9% from Belarus were opposed to providing financial assistance to support foreign cultures and traditions, and the same number believed that foreign students could communicate in their language in local offices. The Polish students’ most positive features were attributed to the Italian, French, and Greek, whereas the Belarusian students held the British, Finnish and French in the highest esteem. The Polish respondent's most negative features were attributed to Gypsies and Russians, and the Belarusian students had the lowest esteem for the Germans, Arabs and Chechens. Conclusions: Poles are not tolerant nation, but their acceptance is increasing. Belarusians are tolerant, but their acceptance is declining. We found differences in the positive and negative perceptions of other nations depending on the nationality
EN
Introduction: The use of mobile phones has increased worldwide during the last decade especially in adolescents. Purpose: To examine the role of a mobile phone in the students' life, signs of addiction, and whether there are differences in phone using between the Polish and Belarusian students. Materials and methods: The study comprised 160 students from Belarus and 227 from Poland. We used a questionnaire included the test of mobile phone addiction. Results: Most of the students had the mobile phones. Of the students 35.2% from Poland and 68.8% from Belarus were convinced on the harmful effects of mobile phone. Most respondents declared that the mobile phone could switch off in the theatre (65.2% from Poland, 30% from Belarus), and in the church (60.8% from Poland, 33.8% from Belarus). Of the students, 46% from Poland and 28.8% from Belarus knew a monophobia definition. The majority of respondents from Poland (83.7%) and Belarus (71.9%) have never switched off their phones. Overall, 22.9% of the Polish students and 10.4% of Belarusian students had the symptoms of mobile phone-addiction. Conclusions: Most students from Poland and Belarus were convinced on the harmful effect of the mobile phone using. More respondents from Poland than Belarus knew that mobile phone users could be addicted. Almost 1/5 of students from Poland and 1/10 from Belarus had the symptoms of mobile phone-addiction.
EN
Introduction: Little is known about associations of attitudes of medical students towards people with disabilities and their life satisfaction and empathy. Purpose: To assess the social perception of people with disabilities by medical students. Materials and methods: The present study interviewed 451 medical students of the Medical University of Białystok regarding their perceptions of people with disabilities, especially in light of their own satisfaction with life and empathy. We used the following questionnaires: the original questionnaire about attitudes towards people with disabilities, The Satisfaction with Life Scale (SWLS), and Empathy Understanding Questionnaire (KRE). Results: Attitudes towards people with disabilities people were generally positive. Almost 40% of respondents expressed a willingness to help for people with disabilities. In general, disabled people do not have full access to all fields of social (63.4%) and professional (63.2%) life. At the same time, disabled people tend to marry (84.9%), have children (82.1%), work (88.2%), and drive cars (76.1%). Respondents were convinced that contact with a disabled person teaches ways to help others (42.1%), and in fact 58.6% of respondents reported having decided to participate with helping the disabled. The average life satisfaction of the students was 22.7 ± 5.3 which indicates that the respondents are satisfied with their lives. The empathy level of respondents was 66.97 points ± 2.98, which indicates average level of empathy. Conclusions: This study shows that students’ perception of people with disabilities depends upon how the students viewed disabled people’s, life satisfaction and empathy.
EN
Introduction: In Poland, the incidence of malignant melanoma increases each year. Purpose: To assess the students’ knowledge about sunbed use and side effect of solar radiation. Materials and methods: The study was carried out among 577 students of the Medical University of Białystok based on a ‘sunbed survey’. Results: Of the 577 students, 390 (67.6%) had used a sunbed. Tanning 273 (70%) and preparation for sunny holidays 201 (51.6%) were the main reasons for sunbed use. Almost 61% of respondents were against the sunbed use by children or youths. SPF abbreviation was known by 64.4% of students. Most respondents 73.9% used the UVR-protection cosmetics in summer usually (66.9%). They avoided sun tanning between Noon - 15 o’clock (43.1%). Tanorexia as “an addiction to tanning” was defined by 27.4% of the respondents. The main sources of knowledge on sunbeds and side-effects of solar radiation were: magazines (34.6%) the Internet (29.5%) and TV (28.1%). Conclusions: The students’ knowledge about sunbed use and side-effect of solar radiation was varied. The majority of respondents knew that tanning to be a health risk, and they were against sunbeds could be used by children and youths. Most the surveyed did not know tanorexia term
EN
Introduction: Exercise at various durations and intensities impact on blood and stem cells. This pilot study examined the effects of 30 minutes of treadmill walking on hematological indices and progenitor stem cells CD34+ in healthy subjects. Materials and methods: A total of 17 non-smoking, healthy students, aged 20 to 22 years participated. Hemoglobin, hematocrit, white blood cells, platelets, and stem cell CD34+ numbers were assessed before and after moderate exercise. Statistical analyses examined the relationships between CD34+ cells versus hematological indices, age, and body mass index. Results: Following exercise, significant increases were observed in leukocytes, neutrophils, eosinophils, and CD34+ cells numbers. For CD34+ cells, a fourfold increase was seen. Significant correlations between CD34+ cells, white blood cells, and neutrophils were found. Conclusion: Our results suggest that moderate exercise has a physiological impact on hematologic parameters and stem cells CD34+ in healthy subjects. Furthermore, our findings suggest that brief treadmill exercise may enhance tissue repair mechanisms so important in physiotherapy.
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