The article tells about the history of development the first biological methods of treatment of schizophrenia, introduced after the II World War. At first, there was insulin shock therapy, introduced for the first time in 1933, then electroconvulsive therapy, applied in 1938 and lobotomy, which became popular method of treatment in 40s and 50s. Introducing every of this methods was an important step in schizophrenia research, altough all of them were mainly ineffective. Moreover all of this methods contain many side effects, even dangerous to life. It seems that development of each of this methods was crucial step important to introduce much more effective and safety ways of treatment of this disease.
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