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Inhibition of 12/15-LOX activity and ceramide pattern in the murine brain

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Fiedorowicz A., Car H., Prokopiuk S., Sacharzewska E., Żendzian-Piotrowska M., Kowal K.
Progress in Health Sciences
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2013
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vol. 3
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issue 1
33-38
EN
Purpose: The 12/15-lipoxygenase (12/15-LOX) activity and the ceramide content are often elevated in neurodegenerative disorders; however their relationship in the brain is not established. To verify whether blocking of 12/15-LOX activity has an impact on ceramide pattern in the brain we inhibited the 12/15-LOX expression by administration of baicalein in mice. Materials and methods: The ceramides containing fatty acid methyl esters were analyzed using gas–liquid chromatography (GLC) technique. Results: The total ceramide content increased in baicalein-treated animals comparing to controls and the levels of most ceramide-fatty acids of SAFA, MUFA and PUFA tended to increase in relation to control. Baicalein treatment up-regulated significantly only the ceramide-lignoceric fatty acid in relation to controls. Conclusion: We have shown in this study that 12/15-LOX inhibition slightly alters the pattern of ceramides in the mouse brain.
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