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1

The relationship between metronidazole concentration and clinicopathological parameters in patients with colon cancer: A pilot study

100%
Sadowska A., Car H., Rodziewicz L., Cepowicz D., Kędra B.
Progress in Health Sciences
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2013
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vol. 3
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issue 2
74-81
EN
Purpose: To evaluate the concentration of metronidazole (MTZ) and its hydroxy metabolite (MTZOH) in cancer tissue and adjacent normal tissue in colorectal cancer patients in correlation with clinicopathologic parameters. Material and methods: MTZ and MTZOH concentration were measured in tumor tissue and surrounding healthy tissue by LC-ESI-MS-MS method. Results: We found different concentration of MTZ and MTZOH in colorectal cancer and healthy tissue, however the results were not statistically significant. MTZ concentration was elevated in tumors located in rectum, in patients over 60 years old, in patients without metastases to regional lymph nodes (N0) while decreasing with increasing tumor size. Women accumulated greater amounts of MTZ in comparison to men. Conclusion: Comparison of the concentration of the drug and its metabolite in tumor and normal colon tissue shows its different reaction to MTZ. MTZ concentration in the tumor and normal colon tissue is sex-dependent.
2
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Assessment of the presence of pancreatic intraepithelial neoplasia in various diseases of this organ

86%
Zińczuk J., Zaręba K., Konarzewska-Duchnowska E., Guzińska-Ustymowicz K., Kędra B., Kemona A., Pryczynicz A.
Progress in Health Sciences
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2017
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vol. 7(2)
43-49
EN
Purpose: Pancreatic intraepithelial neoplasia (PanIN) is one of the most commonly occurring precancerous lesion in pancreas which leads to development of pancreatic ductal adenocarcinoma (PDAC). We assessed the presence and grade of pancreatic intraepithelial neoplasia in the course of various diseases of the pancreas and its correlations with chosen clinicopathological parameters. null Results: A total of 276 foci of PanIN were identified in 94 patients. The most common lesions were PanIN 1a and PanIN 1b which together constituted 68.2 % of all lesions, whereas the PanIN 2 was present in 21.7% and PanIN 3 in 10.1% of patients. No statistical differences were observed in gender tendency for the development of PanINs. There was correlation between age of patients and degree of PanIN (p=0.034). There is no statistical difference in PanIN frequency among patients with pancreatic ductal adenocarcinomas, neuroendocrine tumors, chronic pancreatitis and pancreatic cysts (p=0.592). Conclusions: Our study showed that important factor in development of pancreatic intraepithelial neoplasia is age and the presence of PanIN in nonneoplastic diseases in older people should be included to the group with increased risk of cancer development.
3
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Spigelian hernia: a case report

86%
Martyniuk M., Ustymowicz W., Zińczuk J., Pryczynicz A., Guzińska-Ustymowicz K., Kędra B., Zaręba K.
Progress in Health Sciences
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2019
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vol. 2
53-56
EN
Spigelian hernias constitute a minute fraction of all abdominal hernias. In this monography, we present a case report of this relatively seldom seen phenomenon which some general surgeons never get to see during their medical career.
4

Assessment of prevalence of HPV DNA in colorectal adenocarcinoma in patients from the Podlasie region

72%
Miąsko A., Chomczyk M., Pancewicz–Wojtkiewicz, J, Roszkowski A., Kędra B., Borzym - Kluczyk M., Szynaka B., Chyczewski L.
Progress in Health Sciences
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2012
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vol. 2
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issue 2
84-89
EN
Purpose: The aim of the study was to assess the prevalence of human papillomavirus (HPV) DNA in colorectal adenocarcinoma in patients from the Podlasie region undergoing surgery for the tumor. Materials and methods: We examined 40 solid colorectal tumors taken during surgical treatment at the 2nd Department of General and Gastrointestinal Surgery, Medical University of Białystok. HPV was detected by means of polymerase chain reaction (PCR) and in situ hybridization (ISH). The tests were performed on formalin-fixed, paraffin-embedded tumor tissue. Two pairs of primers were used for the detection of HPV DNA by PCR. Pair pU-1M/pU-2R enables detection and identification of high-risk HPV (HPV 16, 18, 31, 33, 35, 52b, 58), while pair pU-31B/pU-2R enables detection and identification of low-risk HPV (HPV 6, 11). The ISH was performed with the use of biotin-labelled dsDNA probes, using Wide Spectrum HPV DNA Probe Cocktail Biotinylated kit, DAKO Cyto-mation. Results: HPV DNA was found in 21 (52.5%) of the examined colorectal tumors. The PCR revealed the presence of viral DNA in 19 (47.5%) tumors. The ISH revealed the presence of HPV DNA in 16 (40%) of the examined tumors. Conclusion: The findings of this study correlate with similar results conducted by other research groups. However, this is the first study of colorectal tumor samples taken from patients of the Podlasie region. Therefore, the association between environmental factors, HPV infection, and tumor stage should also be verified in a larger study population. Further studies confirming the presence of HPV DNA in colorectal tumor tissue in populations from different regions of Poland are needed.
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