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Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State

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Al-Tayeb A.-N. O., Abubakr M. H., Elrheima H. A., Habbani A. K., Elrasul R. Y. H.
European Journal of Clinical and Experimental Medicine
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2024
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vol. 22
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issue 1
68-72
EN
Introduction and aim. Methamphetamine-use disorder is a pressing global public health issue. In Sudan, the escalating methamphetamine (METH) consumption has become a significant social and health problem. This study aims to evaluate liver and kidney biomarkers in methamphetamine addicts in Khartoum state. Material and methods. The study was an analytical prospective cross-sectional hospital-based study. One hundred participants were enrolled in this study, fifty were cases (methamphetamine addicts), and others were healthy non-METH users as a comparative group. Results. METH users had a mean age of (27±7) years and had been using METH for an average of (14±9) months. Urea and creatinine levels were also significantly elevated in METH users compared to non-users, with p<0.001 and p=0.044, respectively. Their aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher compared to non-users, with p<0.001. Conclusion. There was significant increases in creatinine, urea, and aminotransferases levels in the case group. ALT showed a moderate positive correlation with abuse duration, while AST showed no significant correlation. Urea and creatinine levels had strong and moderate positive correlations with abuse duration, respectively.
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