Metaloproteinaza macierzowa-9 (MMP-9) i jej znaczenie w patogenezie chorob cywilizacyjnych
MATRIX METALLOPROTEINASE-9 ( MMP-9) AND ITS ROLE IN THE PATHOGENESIS OF THE MOST COMMON CIVILIZATION
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MMP-9 is a member of a family of proteolytic enzymes, zinc and calcium-dependent, of extracellular matrix(ECM) proteinases. MMP-9 is especially active in the degradation of type IV collagen, the main constitutent of the basement membrane and also in degradation of the most of extracellular matrix proteinases . MMP-9 also cleave a variety of non-ECM proteins, such as: cytokines, chemokines and growth factors. Its expression was shown in macrophages and neurophils. MMP-9 take part in many physiological processes such as apoptosis, angiogenesis, wound healing, migration of cells and plays important roles in various aspects of c.n.s functions: brain development, neuroplasticity and epileptigenesis. MMP-9 and their inhibitors (TIMPs) are involved in various pathological processes contributing in this way to pathogenesis of many diseases, including psychiatric disorders. The paper analyses a number of correlations between MMP-9 serum level and development of civilization diseases like cancer, diabetes, heart diseases and arteriosclerosis. It emphasizes the role of the molecular research in looking for association between MMP-9 polymorphism with civilization diseases.. The paper points to the fact that characterization of polymorphism in MMP-9 gene may explain the pathogenesis of psychiatric diseases : schizophrenia, bipolar affective disorder , alcohol and nicotine dependencies.
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