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Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development

100%
Anna Sęk-Mastej A., Sabina Galiniak S., Izabela Krawczyk-Marć I., Krzysztof Balawender K., Artur Szymczak A., Maciej Kaniewski M., Natalia Leksa N., Marek Biesiadecki M., Stanisław Orkisz S.
European Journal of Clinical and Experimental Medicine
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2018
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issue 2
85-91
EN
Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
2
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The Offence of Forced Miscarriage as Documented in the Polish State Archive in Suwałki (1921–1939)

88%
Dworas-Kulik J.
Miscellanea Historico-Iuridica
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2023
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vol. 22
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issue 1
573-592
EN
The Polish term spędzenie płodu (forced miscarriage), used in interwar Poland, meant an intentional termination of pregnancy, now referred to as abortion. Miscarriage was considered an abortion if it was purposely induced by an external factor leading to a preterm delivery, so-called artificial miscarriage, which was carried out with the woman’s consent and resulted in foetal death. The offence of forced miscarriage was regarded as related to murder of a person, so abortion regulations fell in the category of provisions concerning crimes against life. Conditions for the permissibility of terminating a pregnancy were not stipulated in the Russian penal legislation governing this criminal act, which was in force in interwar Poland; instead, the Tagancev Code applied by reference. The Polish Penal Code of 1932 went a step further as it took into account not only the state of absolute necessity, but also health issues in a wider context, which was confirmed by legal scholars in their commentaries. The protection of the mother’s life and health was not associated with the phase of foetal and pregnancy development, because the legislator did not determine the time limit for terminating pregnancy. It was assumed that forced miscarriage could apply to a newly born baby before it was detached from the mother’s organism – a baby that was unable to live independently. In this article, the legal-historical method was used to present a criminal-law analysis of the crime of forced miscarriage in the former Russian Partition, considering the rulings in such cases handed down in the Suwałki District. In the literature of the subject to date, no such a study can be found, which justifies this inquiry.
3
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Induced Abortion in the Contemporary Penitential Praxis of the Catholic Church. How to be an Instrument of New Hope

75%
Polák J.
The Person and the Challenges. The Journal of Theology, Education, Canon Law and Social Studies Inspired by Pope John Paul II
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2020
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vol. 10
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issue 1
215-233
EN
The aim of this paper is to consider how a priest could contribute to the healing of those who are burdened with the crime of induced abortion. The response of the Catholic Church towards this issue, throughout the centuries, deserves to be discussed on the basis of some relevant facts. The topic concerns not only moral theology and canon law but it is also the object of research of modern psychology. A confessor, confronted with procured abortion, should reflect seriously on which type of penance will be a real spiritual medicine for his penitent. This study would like to present some examples. It reflects the actual status quo in some selected dioceses concerning the forum internum. The paper will conclude with some proposals to address such situations.
4
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Starotestamentowe życie nienarodzonych

63%
Węgrzyniak W.
Polonia Sacra
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2013
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vol. 17
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issue 1
EN
The article aims to analyze the Old Testament’s idea of life before birth. Firstly, I examine some expressions describing sexual intercourse. Secondly, I study the meaning of the word הרה hārāh “to conceive”. Thirdly, I analyze some crucial texts (ad es. Rdz 25, 21– 24; Wj 21, 22–25; Hi 10; Ps 139). At the end, I offer a brief synthesis of the Old Testament’s idea about life between conception and birth.
5
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Ochrana embrya a plodu v trestním a občanském právu

51%
Valc J.
Časopis zdravotnického práva a bioetiky (Journal of Medical Law and Bioethics)
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2021
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vol. 11
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issue 1
36-52
EN
What is the status of an embryo and a foetus? This question has been always the object of interest not only to lawyers but also to experts in other disciplines. Despite the fact, that knowledge about the circumstances of the origin and development of human life during the prenatal period has greatly expanded, there is still no consensus on that, when and why each of us once became a person and a holder of rights. The intention of this article is not to provide a wide range of individual philosophical or legal approaches to the problem, but to perform a definition of the legal status of an embryo and a foetus in the Czech Republic, with the focus on the specifics of its legal protection.
CS
Jaký je status embrya a plodu? Tato otázka je od nepaměti objektem zájmu nejen právníků, ale také odborníků z jiných vědních oborů. Přestože se znalosti ohledně okolností vzniku a vývoje lidského života během prenatálního období díky technologickému pokroku značně rozšířily, stále neexistuje shoda ohledně toho, kdy a na základě jakých kritérií se každý z nás stal kdysi osobou a nositelem práv. Záměrem tohoto článku není poskytnout širokou škálu jednotlivých filozofických či právních přístupů, ale vymezit základní východiska právního postavení embrya a plodu v českém trestním a občanském právu, a to se zaměřením na rozsah a specifika jeho právní ochrany.
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